5SYT

Crystal Structure of ZMPSTE24

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003690	molecular_function	double-stranded DNA binding
A	0004175	molecular_function	endopeptidase activity
A	0004222	molecular_function	metalloendopeptidase activity
A	0005515	molecular_function	protein binding
A	0005635	cellular_component	nuclear envelope
A	0005637	cellular_component	nuclear inner membrane
A	0005789	cellular_component	endoplasmic reticulum membrane
A	0006508	biological_process	proteolysis
A	0006998	biological_process	nuclear envelope organization
A	0008233	molecular_function	peptidase activity
A	0008235	molecular_function	metalloexopeptidase activity
A	0008237	molecular_function	metallopeptidase activity
A	0016020	cellular_component	membrane
A	0016787	molecular_function	hydrolase activity
A	0031901	cellular_component	early endosome membrane
A	0031902	cellular_component	late endosome membrane
A	0032991	cellular_component	protein-containing complex
A	0046872	molecular_function	metal ion binding
A	0050688	biological_process	regulation of defense response to virus
A	0051604	biological_process	protein maturation
A	0070062	cellular_component	extracellular exosome
A	0071586	biological_process	CAAX-box protein processing

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	binding site for residue SO4 A 501

Chain	Residue
A	LEU101
A	LEU129
A	PHE133

---

site_id	AC2
Number of Residues	5
Details	binding site for residue SO4 A 502

Chain	Residue
A	SER81
A	TYR84
A	SER85
A	TRP141
A	HOH672

---

site_id	AC3
Number of Residues	12
Details	binding site for residue PC1 A 503

Chain	Residue
A	THR35
A	GLN39
A	ARG43
A	TYR118
A	GLU119
A	ILE120
A	THR121
A	LEU179
A	PRO180
A	SER183
A	LYS190
A	LEU32

---

site_id	AC4
Number of Residues	7
Details	binding site for residue CXE A 504

Chain	Residue
A	LEU127
A	ASN355
A	SER356
A	LEU389
A	PHE392
A	GLN393
A	ASN400

---

site_id	AC5
Number of Residues	4
Details	binding site for residue C8E A 505

Chain	Residue
A	LEU209
A	ASN348
A	ILE349
A	PHE414

---

site_id	AC6
Number of Residues	4
Details	binding site for residue C8E A 506

Chain	Residue
A	ALA135
A	LEU139
A	ALA167
A	C8E511

---

site_id	AC7
Number of Residues	1
Details	binding site for residue C8E A 507

Chain	Residue
A	PRO140

---

site_id	AC8
Number of Residues	5
Details	binding site for residue C8E A 508

Chain	Residue
A	GLU86
A	THR87
A	CYS176
A	ILE177
A	VAL210

---

site_id	AC9
Number of Residues	1
Details	binding site for residue C8E A 509

Chain	Residue
A	GLY97

---

site_id	AD1
Number of Residues	7
Details	binding site for residue C8E A 510

Chain	Residue
A	PHE26
A	SER27
A	SER85
A	GLU86
A	GLU88
A	SER397
A	HOH616

---

site_id	AD2
Number of Residues	10
Details	binding site for residue C8E A 511

Chain	Residue
A	ALA135
A	GLY138
A	LEU139
A	SER142
A	GLN158
A	PHE163
A	ASP166
A	ARG260
A	C8E506
A	HOH684

---

site_id	AD3
Number of Residues	8
Details	binding site for residue C8E A 512

Chain	Residue
A	TRP80
A	LEU83
A	ILE191
A	GLY193
A	TYR199
A	PHE203
A	VAL206
A	HOH632

---

site_id	AD4
Number of Residues	3
Details	binding site for residue C8E A 513

Chain	Residue
A	VAL23
A	ARG369
A	PRO398

---

site_id	AD5
Number of Residues	2
Details	binding site for residue C8E A 514

Chain	Residue
A	ASP194
A	GOL519

---

site_id	AD6
Number of Residues	1
Details	binding site for residue C8E A 515

Chain	Residue
A	PHE95

---

site_id	AD7
Number of Residues	7
Details	binding site for residue C8E A 516

Chain	Residue
A	ASP73
A	THR76
A	PHE77
A	PRO140
A	TRP141
A	TYR144
A	LYS152

---

site_id	AD8
Number of Residues	5
Details	binding site for residue ZN A 517

Chain	Residue
A	HIS335
A	GLU336
A	HIS339
A	GLU415
A	HOH628

---

site_id	AD9
Number of Residues	6
Details	binding site for residue GOL A 518

Chain	Residue
A	ILE189
A	LYS190
A	ILE367
A	THR384
A	HOH608
A	HOH642

---

site_id	AE1
Number of Residues	4
Details	binding site for residue GOL A 519

Chain	Residue
A	VAL365
A	ARG369
A	C8E514
A	HOH605

---

site_id	AE2
Number of Residues	3
Details	binding site for residue PEG A 520

Chain	Residue
A	GLY21
A	LEU25
A	TYR218

---

site_id	AE3
Number of Residues	3
Details	binding site for residue DMS A 521

Chain	Residue
A	PRO230
A	TYR287
A	THR227

---

site_id	AE4
Number of Residues	1
Details	binding site for residue DMS A 522

Chain	Residue
A	LYS152

---

site_id	AE5
Number of Residues	3
Details	binding site for residue DMS A 523

Chain	Residue
A	TYR457
A	SER458
A	HIS459

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	142
Details	Transmembrane: {"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	66
Details	Topological domain: {"description":"Nuclear","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	36
Details	Topological domain: {"description":"Lumenal","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	Active site: {"evidences":[{"source":"PubMed","id":"23539603","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PubMed","id":"23539603","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---