5SYB

Crystal structure of human PHF5A

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000387	biological_process	spliceosomal snRNP assembly
A	0000388	biological_process	spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
A	0000398	biological_process	mRNA splicing, via spliceosome
A	0003677	molecular_function	DNA binding
A	0003723	molecular_function	RNA binding
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005681	cellular_component	spliceosomal complex
A	0005684	cellular_component	U2-type spliceosomal complex
A	0005686	cellular_component	U2 snRNP
A	0005689	cellular_component	U12-type spliceosomal complex
A	0006351	biological_process	DNA-templated transcription
A	0006397	biological_process	mRNA processing
A	0008270	molecular_function	zinc ion binding
A	0008380	biological_process	RNA splicing
A	0016363	cellular_component	nuclear matrix
A	0016607	cellular_component	nuclear speck
A	0045893	biological_process	positive regulation of DNA-templated transcription
A	0046872	molecular_function	metal ion binding
A	0048863	biological_process	stem cell differentiation
A	0071005	cellular_component	U2-type precatalytic spliceosome
A	0071011	cellular_component	precatalytic spliceosome
A	1903241	biological_process	U2-type prespliceosome assembly
B	0000387	biological_process	spliceosomal snRNP assembly
B	0000388	biological_process	spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
B	0000398	biological_process	mRNA splicing, via spliceosome
B	0003677	molecular_function	DNA binding
B	0003723	molecular_function	RNA binding
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005681	cellular_component	spliceosomal complex
B	0005684	cellular_component	U2-type spliceosomal complex
B	0005686	cellular_component	U2 snRNP
B	0005689	cellular_component	U12-type spliceosomal complex
B	0006351	biological_process	DNA-templated transcription
B	0006397	biological_process	mRNA processing
B	0008270	molecular_function	zinc ion binding
B	0008380	biological_process	RNA splicing
B	0016363	cellular_component	nuclear matrix
B	0016607	cellular_component	nuclear speck
B	0045893	biological_process	positive regulation of DNA-templated transcription
B	0046872	molecular_function	metal ion binding
B	0048863	biological_process	stem cell differentiation
B	0071005	cellular_component	U2-type precatalytic spliceosome
B	0071011	cellular_component	precatalytic spliceosome
B	1903241	biological_process	U2-type prespliceosome assembly

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue ZN A 201

Chain	Residue
A	CYS11
A	CYS46
A	CYS49
A	CYS85

---

site_id	AC2
Number of Residues	4
Details	binding site for residue ZN A 202

Chain	Residue
A	CYS30
A	CYS33
A	CYS72
A	CYS75

---

site_id	AC3
Number of Residues	4
Details	binding site for residue ZN A 203

Chain	Residue
A	CYS26
A	CYS58
A	CYS61
A	CYS23

---

site_id	AC4
Number of Residues	4
Details	binding site for residue EDO A 204

Chain	Residue
A	GLY16
A	VAL17
A	ASP47
A	HOH309

---

site_id	AC5
Number of Residues	5
Details	binding site for residue EDO A 205

Chain	Residue
A	PHE10
A	ARG12
A	LYS80
A	ASP83
A	HOH302

---

site_id	AC6
Number of Residues	4
Details	binding site for residue ZN B 201

Chain	Residue
B	CYS11
B	CYS46
B	CYS49
B	CYS85

---

site_id	AC7
Number of Residues	4
Details	binding site for residue ZN B 202

Chain	Residue
B	CYS30
B	CYS33
B	CYS72
B	CYS75

---

site_id	AC8
Number of Residues	4
Details	binding site for residue ZN B 203

Chain	Residue
B	CYS23
B	CYS26
B	CYS58
B	CYS61

---

site_id	AC9
Number of Residues	5
Details	binding site for residue EDO B 204

Chain	Residue
B	PHE10
B	ARG12
B	LYS80
B	ASP83
B	HOH301

---

site_id	AD1
Number of Residues	3
Details	binding site for residue EDO B 205

Chain	Residue
B	GLY16
B	VAL17
B	ASP47

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	32
Details	Region: {"description":"Interaction with SF3B1 and SF3B3","evidences":[{"source":"PubMed","id":"27720643","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	6
Details	Region: {"description":"Interaction with SF3B3","evidences":[{"source":"PubMed","id":"27720643","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	24
Details	Binding site: {"evidences":[{"source":"PubMed","id":"28541300","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5IFE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5SYB","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Site: {"description":"Interaction with SF3B3","evidences":[{"source":"PubMed","id":"27720643","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	Modified residue: {"description":"N-acetylalanine","evidences":[{"source":"UniProtKB","id":"P83870","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---