Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

5SXV

X-ray structure of 2-bromoethanol bound to a pentameric ligand gated ion channel (ELIC) in a resting state

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004888	molecular_function	transmembrane signaling receptor activity
A	0005216	molecular_function	monoatomic ion channel activity
A	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
A	0006811	biological_process	monoatomic ion transport
A	0016020	cellular_component	membrane
A	0034220	biological_process	monoatomic ion transmembrane transport
B	0004888	molecular_function	transmembrane signaling receptor activity
B	0005216	molecular_function	monoatomic ion channel activity
B	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
B	0006811	biological_process	monoatomic ion transport
B	0016020	cellular_component	membrane
B	0034220	biological_process	monoatomic ion transmembrane transport
C	0004888	molecular_function	transmembrane signaling receptor activity
C	0005216	molecular_function	monoatomic ion channel activity
C	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
C	0006811	biological_process	monoatomic ion transport
C	0016020	cellular_component	membrane
C	0034220	biological_process	monoatomic ion transmembrane transport
D	0004888	molecular_function	transmembrane signaling receptor activity
D	0005216	molecular_function	monoatomic ion channel activity
D	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
D	0006811	biological_process	monoatomic ion transport
D	0016020	cellular_component	membrane
D	0034220	biological_process	monoatomic ion transmembrane transport
E	0004888	molecular_function	transmembrane signaling receptor activity
E	0005216	molecular_function	monoatomic ion channel activity
E	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
E	0006811	biological_process	monoatomic ion transport
E	0016020	cellular_component	membrane
E	0034220	biological_process	monoatomic ion transmembrane transport
F	0004888	molecular_function	transmembrane signaling receptor activity
F	0005216	molecular_function	monoatomic ion channel activity
F	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
F	0006811	biological_process	monoatomic ion transport
F	0016020	cellular_component	membrane
F	0034220	biological_process	monoatomic ion transmembrane transport
G	0004888	molecular_function	transmembrane signaling receptor activity
G	0005216	molecular_function	monoatomic ion channel activity
G	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
G	0006811	biological_process	monoatomic ion transport
G	0016020	cellular_component	membrane
G	0034220	biological_process	monoatomic ion transmembrane transport
H	0004888	molecular_function	transmembrane signaling receptor activity
H	0005216	molecular_function	monoatomic ion channel activity
H	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
H	0006811	biological_process	monoatomic ion transport
H	0016020	cellular_component	membrane
H	0034220	biological_process	monoatomic ion transmembrane transport
I	0004888	molecular_function	transmembrane signaling receptor activity
I	0005216	molecular_function	monoatomic ion channel activity
I	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
I	0006811	biological_process	monoatomic ion transport
I	0016020	cellular_component	membrane
I	0034220	biological_process	monoatomic ion transmembrane transport
J	0004888	molecular_function	transmembrane signaling receptor activity
J	0005216	molecular_function	monoatomic ion channel activity
J	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
J	0006811	biological_process	monoatomic ion transport
J	0016020	cellular_component	membrane
J	0034220	biological_process	monoatomic ion transmembrane transport

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	binding site for residue BRJ A 401

Chain	Residue
A	PRO74
A	LEU76
A	TYR102

site_id	AC2
Number of Residues	1
Details	binding site for residue BRJ A 402

Chain	Residue
A	PHE78

site_id	AC3
Number of Residues	5
Details	binding site for residue BRJ A 403

Chain	Residue
A	ILE20
A	ASN21
A	ILE23
A	GLU150
A	ILE152

site_id	AC4
Number of Residues	3
Details	binding site for residue BRJ B 401

Chain	Residue
B	ALA41
B	PRO74
B	TYR102

site_id	AC5
Number of Residues	2
Details	binding site for residue BRJ B 402

Chain	Residue
B	PHE78
B	PHE106

site_id	AC6
Number of Residues	2
Details	binding site for residue BRJ B 403

Chain	Residue
B	ASN21
B	ILE23

site_id	AC7
Number of Residues	3
Details	binding site for residue MES B 404

Chain	Residue
A	TRP206
B	THR259
B	GLN264

site_id	AC8
Number of Residues	3
Details	binding site for residue MES B 405

Chain	Residue
B	SER202
B	TRP206
C	THR259

site_id	AC9
Number of Residues	5
Details	binding site for residue BRJ C 401

Chain	Residue
C	ILE39
C	ALA41
C	PRO74
C	LEU76
C	TYR102

site_id	AD1
Number of Residues	3
Details	binding site for residue BRJ C 402

Chain	Residue
C	LEU76
C	PHE78
C	PHE106

site_id	AD2
Number of Residues	6
Details	binding site for residue BRJ C 403

Chain	Residue
C	ILE20
C	ASN21
C	LYS22
C	GLU150
C	ILE152
C	ILE162

site_id	AD3
Number of Residues	3
Details	binding site for residue BRJ D 401

Chain	Residue
D	VAL73
D	PRO74
D	TYR102

site_id	AD4
Number of Residues	2
Details	binding site for residue BRJ D 402

Chain	Residue
D	LEU76
D	PHE78

site_id	AD5
Number of Residues	2
Details	binding site for residue BRJ D 403

Chain	Residue
D	GLU150
D	ILE162

site_id	AD6
Number of Residues	3
Details	binding site for residue MES D 404

Chain	Residue
C	TRP206
D	THR259
D	GLN264

site_id	AD7
Number of Residues	2
Details	binding site for residue MES D 405

Chain	Residue
D	TRP206
E	GLN264

site_id	AD8
Number of Residues	2
Details	binding site for residue BRJ E 401

Chain	Residue
A	THR237
E	THR237

site_id	AD9
Number of Residues	3
Details	binding site for residue BRJ E 402

Chain	Residue
E	PRO74
E	LEU76
E	TYR102

site_id	AE1
Number of Residues	2
Details	binding site for residue BRJ E 403

Chain	Residue
E	PHE78
E	PHE106

site_id	AE2
Number of Residues	3
Details	binding site for residue BRJ E 404

Chain	Residue
E	ILE20
E	ASN21
E	GLU150

site_id	AE3
Number of Residues	2
Details	binding site for residue MES E 405

Chain	Residue
A	GLN264
E	TRP206

site_id	AE4
Number of Residues	4
Details	binding site for residue BRJ F 401

Chain	Residue
F	ALA41
F	PRO74
F	LEU76
F	TYR102

site_id	AE5
Number of Residues	2
Details	binding site for residue BRJ F 402

Chain	Residue
F	PHE78
F	PHE106

site_id	AE6
Number of Residues	4
Details	binding site for residue BRJ F 403

Chain	Residue
F	ILE20
F	ASN21
F	GLU150
F	ILE152

site_id	AE7
Number of Residues	2
Details	binding site for residue MES F 404

Chain	Residue
F	TRP206
G	GLN264

site_id	AE8
Number of Residues	5
Details	binding site for residue BRJ G 402

Chain	Residue
G	ALA41
G	VAL73
G	PRO74
G	LEU76
G	TYR102

site_id	AE9
Number of Residues	1
Details	binding site for residue BRJ G 403

Chain	Residue
G	PHE78

site_id	AF1
Number of Residues	4
Details	binding site for residue BRJ G 404

Chain	Residue
G	ILE20
G	ASN21
G	ILE23
G	GLU150

site_id	AF2
Number of Residues	2
Details	binding site for residue MES G 405

Chain	Residue
G	TRP206
H	THR259

site_id	AF3
Number of Residues	4
Details	binding site for residue BRJ H 401

Chain	Residue
H	ALA41
H	PRO74
H	LEU76
H	TYR102

site_id	AF4
Number of Residues	2
Details	binding site for residue BRJ H 402

Chain	Residue
H	PHE78
H	THR87

site_id	AF5
Number of Residues	5
Details	binding site for residue BRJ H 403

Chain	Residue
H	ILE20
H	ASN21
H	THR149
H	GLU150
H	ILE152

site_id	AF6
Number of Residues	3
Details	binding site for residue MES H 404

Chain	Residue
H	TRP206
I	THR259
I	GLN264

site_id	AF7
Number of Residues	5
Details	binding site for residue BRJ I 401

Chain	Residue
I	PRO74
I	ALA75
I	LEU76
I	TYR102
I	ALA41

site_id	AF8
Number of Residues	2
Details	binding site for residue BRJ I 402

Chain	Residue
I	PHE78
I	THR87

site_id	AF9
Number of Residues	4
Details	binding site for residue BRJ I 403

Chain	Residue
I	ILE20
I	ASN21
I	LYS22
I	GLU150

site_id	AG1
Number of Residues	2
Details	binding site for residue MES I 404

Chain	Residue
I	TRP206
J	THR259

site_id	AG2
Number of Residues	4
Details	binding site for residue BRJ J 401

Chain	Residue
J	ALA41
J	PRO74
J	LEU76
J	TYR102

site_id	AG3
Number of Residues	2
Details	binding site for residue BRJ J 402

Chain	Residue
J	PHE78
J	PHE106

site_id	AG4
Number of Residues	3
Details	binding site for residue BRJ J 403

Chain	Residue
J	ASN21
J	LYS22
J	GLU150

site_id	AG5
Number of Residues	1
Details	binding site for residue MES J 404

Chain	Residue
F	GLN264

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	600
Details	Transmembrane: {"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	220
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	90
Details	Topological domain: {"description":"Periplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	80
Details	Motif: {"description":"Cys-loop"}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)