5SXU
X-ray structure of 2-bromoethanol bound to a pentameric ligand gated ion channel (ELIC) in a desensitized state
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004888 | molecular_function | transmembrane signaling receptor activity |
| A | 0005216 | molecular_function | monoatomic ion channel activity |
| A | 0005230 | molecular_function | extracellular ligand-gated monoatomic ion channel activity |
| A | 0006811 | biological_process | monoatomic ion transport |
| A | 0007165 | biological_process | signal transduction |
| A | 0016020 | cellular_component | membrane |
| A | 0034220 | biological_process | monoatomic ion transmembrane transport |
| A | 0042391 | biological_process | regulation of membrane potential |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0043005 | cellular_component | neuron projection |
| B | 0004888 | molecular_function | transmembrane signaling receptor activity |
| B | 0005216 | molecular_function | monoatomic ion channel activity |
| B | 0005230 | molecular_function | extracellular ligand-gated monoatomic ion channel activity |
| B | 0006811 | biological_process | monoatomic ion transport |
| B | 0007165 | biological_process | signal transduction |
| B | 0016020 | cellular_component | membrane |
| B | 0034220 | biological_process | monoatomic ion transmembrane transport |
| B | 0042391 | biological_process | regulation of membrane potential |
| B | 0042802 | molecular_function | identical protein binding |
| B | 0043005 | cellular_component | neuron projection |
| C | 0004888 | molecular_function | transmembrane signaling receptor activity |
| C | 0005216 | molecular_function | monoatomic ion channel activity |
| C | 0005230 | molecular_function | extracellular ligand-gated monoatomic ion channel activity |
| C | 0006811 | biological_process | monoatomic ion transport |
| C | 0007165 | biological_process | signal transduction |
| C | 0016020 | cellular_component | membrane |
| C | 0034220 | biological_process | monoatomic ion transmembrane transport |
| C | 0042391 | biological_process | regulation of membrane potential |
| C | 0042802 | molecular_function | identical protein binding |
| C | 0043005 | cellular_component | neuron projection |
| D | 0004888 | molecular_function | transmembrane signaling receptor activity |
| D | 0005216 | molecular_function | monoatomic ion channel activity |
| D | 0005230 | molecular_function | extracellular ligand-gated monoatomic ion channel activity |
| D | 0006811 | biological_process | monoatomic ion transport |
| D | 0007165 | biological_process | signal transduction |
| D | 0016020 | cellular_component | membrane |
| D | 0034220 | biological_process | monoatomic ion transmembrane transport |
| D | 0042391 | biological_process | regulation of membrane potential |
| D | 0042802 | molecular_function | identical protein binding |
| D | 0043005 | cellular_component | neuron projection |
| E | 0004888 | molecular_function | transmembrane signaling receptor activity |
| E | 0005216 | molecular_function | monoatomic ion channel activity |
| E | 0005230 | molecular_function | extracellular ligand-gated monoatomic ion channel activity |
| E | 0006811 | biological_process | monoatomic ion transport |
| E | 0007165 | biological_process | signal transduction |
| E | 0016020 | cellular_component | membrane |
| E | 0034220 | biological_process | monoatomic ion transmembrane transport |
| E | 0042391 | biological_process | regulation of membrane potential |
| E | 0042802 | molecular_function | identical protein binding |
| E | 0043005 | cellular_component | neuron projection |
| F | 0004888 | molecular_function | transmembrane signaling receptor activity |
| F | 0005216 | molecular_function | monoatomic ion channel activity |
| F | 0005230 | molecular_function | extracellular ligand-gated monoatomic ion channel activity |
| F | 0006811 | biological_process | monoatomic ion transport |
| F | 0007165 | biological_process | signal transduction |
| F | 0016020 | cellular_component | membrane |
| F | 0034220 | biological_process | monoatomic ion transmembrane transport |
| F | 0042391 | biological_process | regulation of membrane potential |
| F | 0042802 | molecular_function | identical protein binding |
| F | 0043005 | cellular_component | neuron projection |
| G | 0004888 | molecular_function | transmembrane signaling receptor activity |
| G | 0005216 | molecular_function | monoatomic ion channel activity |
| G | 0005230 | molecular_function | extracellular ligand-gated monoatomic ion channel activity |
| G | 0006811 | biological_process | monoatomic ion transport |
| G | 0007165 | biological_process | signal transduction |
| G | 0016020 | cellular_component | membrane |
| G | 0034220 | biological_process | monoatomic ion transmembrane transport |
| G | 0042391 | biological_process | regulation of membrane potential |
| G | 0042802 | molecular_function | identical protein binding |
| G | 0043005 | cellular_component | neuron projection |
| H | 0004888 | molecular_function | transmembrane signaling receptor activity |
| H | 0005216 | molecular_function | monoatomic ion channel activity |
| H | 0005230 | molecular_function | extracellular ligand-gated monoatomic ion channel activity |
| H | 0006811 | biological_process | monoatomic ion transport |
| H | 0007165 | biological_process | signal transduction |
| H | 0016020 | cellular_component | membrane |
| H | 0034220 | biological_process | monoatomic ion transmembrane transport |
| H | 0042391 | biological_process | regulation of membrane potential |
| H | 0042802 | molecular_function | identical protein binding |
| H | 0043005 | cellular_component | neuron projection |
| I | 0004888 | molecular_function | transmembrane signaling receptor activity |
| I | 0005216 | molecular_function | monoatomic ion channel activity |
| I | 0005230 | molecular_function | extracellular ligand-gated monoatomic ion channel activity |
| I | 0006811 | biological_process | monoatomic ion transport |
| I | 0007165 | biological_process | signal transduction |
| I | 0016020 | cellular_component | membrane |
| I | 0034220 | biological_process | monoatomic ion transmembrane transport |
| I | 0042391 | biological_process | regulation of membrane potential |
| I | 0042802 | molecular_function | identical protein binding |
| I | 0043005 | cellular_component | neuron projection |
| J | 0004888 | molecular_function | transmembrane signaling receptor activity |
| J | 0005216 | molecular_function | monoatomic ion channel activity |
| J | 0005230 | molecular_function | extracellular ligand-gated monoatomic ion channel activity |
| J | 0006811 | biological_process | monoatomic ion transport |
| J | 0007165 | biological_process | signal transduction |
| J | 0016020 | cellular_component | membrane |
| J | 0034220 | biological_process | monoatomic ion transmembrane transport |
| J | 0042391 | biological_process | regulation of membrane potential |
| J | 0042802 | molecular_function | identical protein binding |
| J | 0043005 | cellular_component | neuron projection |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | binding site for residue BRJ A 401 |
| Chain | Residue |
| A | PRO74 |
| A | ALA75 |
| A | LEU76 |
| A | TYR102 |
| A | BRJ402 |
| site_id | AC2 |
| Number of Residues | 3 |
| Details | binding site for residue BRJ A 402 |
| Chain | Residue |
| A | THR87 |
| A | TYR102 |
| A | BRJ401 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | binding site for residue BRJ A 403 |
| Chain | Residue |
| A | ASN21 |
| A | THR149 |
| A | GLU150 |
| A | ILE152 |
| A | ILE162 |
| A | ILE20 |
| site_id | AC4 |
| Number of Residues | 1 |
| Details | binding site for residue BRJ A 404 |
| Chain | Residue |
| E | THR237 |
| site_id | AC5 |
| Number of Residues | 2 |
| Details | binding site for residue 3CN A 405 |
| Chain | Residue |
| A | PHE19 |
| A | ASN103 |
| site_id | AC6 |
| Number of Residues | 3 |
| Details | binding site for residue MES A 406 |
| Chain | Residue |
| A | TRP206 |
| B | THR259 |
| B | GLN264 |
| site_id | AC7 |
| Number of Residues | 3 |
| Details | binding site for residue BRJ B 401 |
| Chain | Residue |
| B | PRO74 |
| B | LEU76 |
| B | TYR102 |
| site_id | AC8 |
| Number of Residues | 2 |
| Details | binding site for residue BRJ B 402 |
| Chain | Residue |
| B | LEU76 |
| B | PHE78 |
| site_id | AC9 |
| Number of Residues | 2 |
| Details | binding site for residue BRJ B 403 |
| Chain | Residue |
| B | ILE20 |
| B | ILE23 |
| site_id | AD1 |
| Number of Residues | 4 |
| Details | binding site for residue 3CN B 404 |
| Chain | Residue |
| B | PHE19 |
| B | TYR38 |
| B | ASN103 |
| C | TYR175 |
| site_id | AD2 |
| Number of Residues | 4 |
| Details | binding site for residue MES B 405 |
| Chain | Residue |
| B | SER202 |
| B | TRP206 |
| C | THR259 |
| C | GLN264 |
| site_id | AD3 |
| Number of Residues | 4 |
| Details | binding site for residue BRJ C 401 |
| Chain | Residue |
| C | PRO74 |
| C | ALA75 |
| C | LEU76 |
| C | TYR102 |
| site_id | AD4 |
| Number of Residues | 2 |
| Details | binding site for residue BRJ C 402 |
| Chain | Residue |
| C | PHE78 |
| C | PHE106 |
| site_id | AD5 |
| Number of Residues | 2 |
| Details | binding site for residue BRJ C 403 |
| Chain | Residue |
| C | ASN21 |
| C | ILE162 |
| site_id | AD6 |
| Number of Residues | 2 |
| Details | binding site for residue 3CN C 404 |
| Chain | Residue |
| C | PHE19 |
| C | ASN103 |
| site_id | AD7 |
| Number of Residues | 3 |
| Details | binding site for residue MES C 405 |
| Chain | Residue |
| C | TRP206 |
| D | THR259 |
| D | GLN264 |
| site_id | AD8 |
| Number of Residues | 2 |
| Details | binding site for residue CL C 406 |
| Chain | Residue |
| C | HIS177 |
| I | ARG163 |
| site_id | AD9 |
| Number of Residues | 6 |
| Details | binding site for residue BRJ D 401 |
| Chain | Residue |
| D | ALA41 |
| D | PRO74 |
| D | ALA75 |
| D | LEU76 |
| D | TYR102 |
| D | BRJ402 |
| site_id | AE1 |
| Number of Residues | 5 |
| Details | binding site for residue BRJ D 402 |
| Chain | Residue |
| D | LEU76 |
| D | PHE78 |
| D | THR87 |
| D | PHE106 |
| D | BRJ401 |
| site_id | AE2 |
| Number of Residues | 4 |
| Details | binding site for residue BRJ D 403 |
| Chain | Residue |
| D | ASN21 |
| D | ILE23 |
| D | GLU150 |
| D | ILE195 |
| site_id | AE3 |
| Number of Residues | 3 |
| Details | binding site for residue 3CN D 404 |
| Chain | Residue |
| D | PHE19 |
| D | ASN103 |
| E | TYR175 |
| site_id | AE4 |
| Number of Residues | 3 |
| Details | binding site for residue MES D 405 |
| Chain | Residue |
| D | TRP206 |
| E | THR259 |
| E | GLN264 |
| site_id | AE5 |
| Number of Residues | 3 |
| Details | binding site for residue 3CN E 501 |
| Chain | Residue |
| E | PHE19 |
| E | TYR38 |
| E | ASN103 |
| site_id | AE6 |
| Number of Residues | 5 |
| Details | binding site for residue BRJ E 502 |
| Chain | Residue |
| E | ALA41 |
| E | PRO74 |
| E | ALA75 |
| E | LEU76 |
| E | TYR102 |
| site_id | AE7 |
| Number of Residues | 1 |
| Details | binding site for residue BRJ E 503 |
| Chain | Residue |
| E | THR87 |
| site_id | AE8 |
| Number of Residues | 4 |
| Details | binding site for residue BRJ E 504 |
| Chain | Residue |
| E | ILE20 |
| E | ASN21 |
| E | LYS22 |
| E | ILE23 |
| site_id | AE9 |
| Number of Residues | 4 |
| Details | binding site for residue MES E 505 |
| Chain | Residue |
| A | THR259 |
| A | GLN264 |
| E | GLU156 |
| E | TRP206 |
| site_id | AF1 |
| Number of Residues | 5 |
| Details | binding site for residue BRJ F 401 |
| Chain | Residue |
| F | ALA41 |
| F | PRO74 |
| F | ALA75 |
| F | LEU76 |
| F | TYR102 |
| site_id | AF2 |
| Number of Residues | 2 |
| Details | binding site for residue BRJ F 402 |
| Chain | Residue |
| F | PHE78 |
| F | PHE106 |
| site_id | AF3 |
| Number of Residues | 3 |
| Details | binding site for residue BRJ F 403 |
| Chain | Residue |
| F | ASN21 |
| F | GLU150 |
| F | ILE152 |
| site_id | AF4 |
| Number of Residues | 3 |
| Details | binding site for residue BRJ F 404 |
| Chain | Residue |
| H | THR237 |
| J | THR237 |
| F | THR237 |
| site_id | AF5 |
| Number of Residues | 3 |
| Details | binding site for residue 3CN F 405 |
| Chain | Residue |
| F | PHE19 |
| F | TYR38 |
| F | ASN103 |
| site_id | AF6 |
| Number of Residues | 2 |
| Details | binding site for residue MES F 406 |
| Chain | Residue |
| F | TRP206 |
| G | THR259 |
| site_id | AF7 |
| Number of Residues | 6 |
| Details | binding site for residue BRJ G 401 |
| Chain | Residue |
| G | ALA41 |
| G | PRO74 |
| G | ALA75 |
| G | LEU76 |
| G | TYR102 |
| G | BRJ402 |
| site_id | AF8 |
| Number of Residues | 5 |
| Details | binding site for residue BRJ G 402 |
| Chain | Residue |
| G | LEU76 |
| G | PHE78 |
| G | THR87 |
| G | TYR102 |
| G | BRJ401 |
| site_id | AF9 |
| Number of Residues | 3 |
| Details | binding site for residue BRJ G 403 |
| Chain | Residue |
| G | ILE20 |
| G | ASN21 |
| G | GLU150 |
| site_id | AG1 |
| Number of Residues | 4 |
| Details | binding site for residue 3CN G 404 |
| Chain | Residue |
| G | PHE19 |
| G | TYR38 |
| G | ASN103 |
| H | TYR175 |
| site_id | AG2 |
| Number of Residues | 2 |
| Details | binding site for residue MES G 405 |
| Chain | Residue |
| G | TRP206 |
| H | THR259 |
| site_id | AG3 |
| Number of Residues | 5 |
| Details | binding site for residue BRJ H 401 |
| Chain | Residue |
| H | PRO74 |
| H | ALA75 |
| H | LEU76 |
| H | TYR102 |
| H | BRJ402 |
| site_id | AG4 |
| Number of Residues | 3 |
| Details | binding site for residue BRJ H 402 |
| Chain | Residue |
| H | LEU76 |
| H | PHE78 |
| H | BRJ401 |
| site_id | AG5 |
| Number of Residues | 3 |
| Details | binding site for residue BRJ H 403 |
| Chain | Residue |
| H | ASN21 |
| H | GLU150 |
| H | ILE152 |
| site_id | AG6 |
| Number of Residues | 3 |
| Details | binding site for residue 3CN H 404 |
| Chain | Residue |
| H | PHE19 |
| H | ASN103 |
| I | TYR175 |
| site_id | AG7 |
| Number of Residues | 3 |
| Details | binding site for residue MES H 405 |
| Chain | Residue |
| H | TRP206 |
| I | THR259 |
| I | GLN264 |
| site_id | AG8 |
| Number of Residues | 5 |
| Details | binding site for residue BRJ I 401 |
| Chain | Residue |
| I | ALA41 |
| I | PRO74 |
| I | ALA75 |
| I | LEU76 |
| I | TYR102 |
| site_id | AG9 |
| Number of Residues | 2 |
| Details | binding site for residue BRJ I 402 |
| Chain | Residue |
| I | PHE78 |
| I | TYR102 |
| site_id | AH1 |
| Number of Residues | 4 |
| Details | binding site for residue BRJ I 403 |
| Chain | Residue |
| I | ILE20 |
| I | ILE23 |
| I | ILE162 |
| I | ILE195 |
| site_id | AH2 |
| Number of Residues | 2 |
| Details | binding site for residue 3CN I 404 |
| Chain | Residue |
| I | PHE19 |
| I | ASN103 |
| site_id | AH3 |
| Number of Residues | 3 |
| Details | binding site for residue MES I 405 |
| Chain | Residue |
| I | TRP206 |
| J | THR259 |
| J | GLN264 |
| site_id | AH4 |
| Number of Residues | 1 |
| Details | binding site for residue 3CN J 501 |
| Chain | Residue |
| J | ASN103 |
| site_id | AH5 |
| Number of Residues | 5 |
| Details | binding site for residue BRJ J 502 |
| Chain | Residue |
| J | VAL73 |
| J | PRO74 |
| J | ALA75 |
| J | LEU76 |
| J | TYR102 |
| site_id | AH6 |
| Number of Residues | 2 |
| Details | binding site for residue BRJ J 504 |
| Chain | Residue |
| J | ASN21 |
| J | GLU150 |
| site_id | AH7 |
| Number of Residues | 2 |
| Details | binding site for residue MES J 505 |
| Chain | Residue |
| F | THR259 |
| J | TRP206 |
| site_id | AH8 |
| Number of Residues | 1 |
| Details | binding site for residue CL J 506 |
| Chain | Residue |
| J | LYS90 |
