5SVB

Mechanism of ATP-Dependent Acetone Carboxylation, Acetone Carboxylase AMP bound structure

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0003824	molecular_function	catalytic activity
A	0005524	molecular_function	ATP binding
A	0016874	molecular_function	ligase activity
A	0018710	molecular_function	acetone carboxylase activity
A	0140977	biological_process	cellular detoxification of acetone
B	0000166	molecular_function	nucleotide binding
B	0005524	molecular_function	ATP binding
B	0005829	cellular_component	cytosol
B	0006749	biological_process	glutathione metabolic process
B	0016787	molecular_function	hydrolase activity
B	0016874	molecular_function	ligase activity
B	0017168	molecular_function	5-oxoprolinase (ATP-hydrolyzing) activity
B	0018710	molecular_function	acetone carboxylase activity
B	0140977	biological_process	cellular detoxification of acetone
C	0000166	molecular_function	nucleotide binding
C	0005524	molecular_function	ATP binding
C	0016874	molecular_function	ligase activity
C	0018710	molecular_function	acetone carboxylase activity
C	0140977	biological_process	cellular detoxification of acetone
D	0000166	molecular_function	nucleotide binding
D	0003824	molecular_function	catalytic activity
D	0005524	molecular_function	ATP binding
D	0016874	molecular_function	ligase activity
D	0018710	molecular_function	acetone carboxylase activity
D	0140977	biological_process	cellular detoxification of acetone
E	0000166	molecular_function	nucleotide binding
E	0005524	molecular_function	ATP binding
E	0005829	cellular_component	cytosol
E	0006749	biological_process	glutathione metabolic process
E	0016787	molecular_function	hydrolase activity
E	0016874	molecular_function	ligase activity
E	0017168	molecular_function	5-oxoprolinase (ATP-hydrolyzing) activity
E	0018710	molecular_function	acetone carboxylase activity
E	0140977	biological_process	cellular detoxification of acetone
F	0000166	molecular_function	nucleotide binding
F	0005524	molecular_function	ATP binding
F	0016874	molecular_function	ligase activity
F	0018710	molecular_function	acetone carboxylase activity
F	0140977	biological_process	cellular detoxification of acetone

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue MN A 801

Chain	Residue
A	GLU89
A	HIS150
A	ASP153
A	HIS175

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site_id	AC2
Number of Residues	19
Details	binding site for residue AMP B 801

Chain	Residue
B	SER391
B	LEU400
B	ASN404
B	PHE405
B	LEU406
B	GLY473
B	ALA474
B	SER691
B	ASP692
B	ALA693
B	THR694
B	THR695
B	SO4802
B	HOH945
B	THR21
B	LYS38
B	GLY311
B	GLY312
B	ALA352

---

site_id	AC3
Number of Residues	5
Details	binding site for residue SO4 B 802

Chain	Residue
B	ASP17
B	ASP309
B	SER501
B	AMP801
B	HOH949

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site_id	AC4
Number of Residues	4
Details	binding site for residue ZN C 201

Chain	Residue
C	CYS74
C	CYS76
C	CYS124
C	CYS127

---

site_id	AC5
Number of Residues	4
Details	binding site for residue MN D 801

Chain	Residue
D	GLU89
D	HIS150
D	ASP153
D	HIS175

---

site_id	AC6
Number of Residues	18
Details	binding site for residue AMP E 801

Chain	Residue
E	THR21
E	LYS38
E	GLY311
E	GLY312
E	ALA352
E	SER391
E	LEU400
E	ASN404
E	PHE405
E	LEU406
E	GLY473
E	ALA474
E	SER691
E	ASP692
E	ALA693
E	THR694
E	THR695
E	SO4802

---

site_id	AC7
Number of Residues	6
Details	binding site for residue SO4 E 802

Chain	Residue
E	ASP17
E	GLY20
E	THR21
E	ASP24
E	ASP309
E	AMP801

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site_id	AC8
Number of Residues	4
Details	binding site for residue ZN F 201

Chain	Residue
F	CYS74
F	CYS76
F	CYS124
F	CYS127

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