5SUQ

Crystal structure of the THO-Sub2 complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0000346	cellular_component	transcription export complex
A	0000398	biological_process	mRNA splicing, via spliceosome
A	0000781	cellular_component	chromosome, telomeric region
A	0003676	molecular_function	nucleic acid binding
A	0003723	molecular_function	RNA binding
A	0003724	molecular_function	RNA helicase activity
A	0003729	molecular_function	mRNA binding
A	0004386	molecular_function	helicase activity
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005634	cellular_component	nucleus
A	0005681	cellular_component	spliceosomal complex
A	0005737	cellular_component	cytoplasm
A	0006283	biological_process	transcription-coupled nucleotide-excision repair
A	0006368	biological_process	transcription elongation by RNA polymerase II
A	0006397	biological_process	mRNA processing
A	0006406	biological_process	mRNA export from nucleus
A	0008380	biological_process	RNA splicing
A	0010467	biological_process	gene expression
A	0016787	molecular_function	hydrolase activity
A	0016887	molecular_function	ATP hydrolysis activity
A	0031124	biological_process	mRNA 3'-end processing
A	0031509	biological_process	subtelomeric heterochromatin formation
A	0042802	molecular_function	identical protein binding
A	0051028	biological_process	mRNA transport
C	0000166	molecular_function	nucleotide binding
C	0000346	cellular_component	transcription export complex
C	0000398	biological_process	mRNA splicing, via spliceosome
C	0000781	cellular_component	chromosome, telomeric region
C	0003676	molecular_function	nucleic acid binding
C	0003723	molecular_function	RNA binding
C	0003724	molecular_function	RNA helicase activity
C	0003729	molecular_function	mRNA binding
C	0004386	molecular_function	helicase activity
C	0005515	molecular_function	protein binding
C	0005524	molecular_function	ATP binding
C	0005634	cellular_component	nucleus
C	0005681	cellular_component	spliceosomal complex
C	0005737	cellular_component	cytoplasm
C	0006283	biological_process	transcription-coupled nucleotide-excision repair
C	0006368	biological_process	transcription elongation by RNA polymerase II
C	0006397	biological_process	mRNA processing
C	0006406	biological_process	mRNA export from nucleus
C	0008380	biological_process	RNA splicing
C	0010467	biological_process	gene expression
C	0016787	molecular_function	hydrolase activity
C	0016887	molecular_function	ATP hydrolysis activity
C	0031124	biological_process	mRNA 3'-end processing
C	0031509	biological_process	subtelomeric heterochromatin formation
C	0042802	molecular_function	identical protein binding
C	0051028	biological_process	mRNA transport

Functional Information from PDB Data

site_id	AC1
Number of Residues	15
Details	binding site for residue KEG A 501

Chain	Residue
A	ASN320
C	GLY338
C	HIS339
C	MET340
C	LYS341
C	GLU344
C	ARG348
A	HIS337
A	GLY338
A	HIS339
A	MET340
A	LYS341
A	GLU344
A	ARG348
C	ASN320

---

site_id	AC2
Number of Residues	9
Details	binding site for residue KEG A 502

Chain	Residue
A	LYS196
A	ARG200
A	ARG228
C	ASN385
C	GLU386
C	ALA387
C	LYS421
C	GLU424
C	ARG425

---

site_id	AC3
Number of Residues	10
Details	binding site for residue KEG A 503

Chain	Residue
A	ARG140
A	GLU141
A	GLY167
A	GLY168
C	LYS314
C	SER315
C	THR316
C	THR363
C	ASP364
C	VAL365

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	350
Details	Domain: {"description":"Helicase ATP-binding","evidences":[{"source":"PROSITE-ProRule","id":"PRU00541","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	322
Details	Domain: {"description":"Helicase C-terminal","evidences":[{"source":"PROSITE-ProRule","id":"PRU00542","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	56
Details	Motif: {"description":"Q motif"}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	6
Details	Motif: {"description":"DECD box"}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	14
Details	Binding site: {}

Chain

Residue

Details

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site_id	SWS_FT_FI6
Number of Residues	2
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"18407956","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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