5SM9

PanDDA analysis group deposition -- Crystal Structure of SARS-CoV-2 NSP14 in complex with Z2234920345

Functional Information from GO Data

Chain	GOid	namespace	contents
D	0000175	molecular_function	3'-5'-RNA exonuclease activity
D	0004482	molecular_function	mRNA 5'-cap (guanine-N7-)-methyltransferase activity
D	0004532	molecular_function	RNA exonuclease activity
D	0008168	molecular_function	methyltransferase activity

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	5
Details	ACT_SITE: ACT_SITE => ECO:0000255|PROSITE-ProRule:PRU01298

Chain	Residue	Details
D	ASP90
D	GLU92
D	GLU191
D	HIS268
D	ASP273

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site_id	SWS_FT_FI2
Number of Residues	17
Details	BINDING: BINDING => ECO:0000269|PubMed:36546776

Chain	Residue	Details
D	ASP90
D	HIS264
D	HIS268
D	ASP273
D	CYS279
D	CYS452
D	CYS477
D	CYS484
D	HIS487
D	GLU92
D	GLU191
D	CYS207
D	CYS210
D	CYS226
D	HIS229
D	HIS257
D	CYS261

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU01299

Chain	Residue	Details
D	ASP331

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site_id	SWS_FT_FI4
Number of Residues	1
Details	SITE: Cleavage; by 3CL-PRO => ECO:0000250|UniProtKB:P0C6V3

Chain	Residue	Details
D	GLN527

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