5SA8
PanDDA analysis group deposition -- Crystal Structure of SARS-CoV-2 NendoU in complex with Z68299550
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 8 |
| Details | binding site for residue JOV A 401 |
| Chain | Residue |
| A | VAL165 |
| A | GLN201 |
| A | PHE258 |
| A | PRO262 |
| A | PHE263 |
| A | GLU264 |
| A | LEU265 |
| A | ALA283 |
| site_id | AC2 |
| Number of Residues | 8 |
| Details | binding site for residue JOV B 401 |
| Chain | Residue |
| B | GLU202 |
| B | PHE258 |
| B | PRO262 |
| B | PHE263 |
| B | GLU264 |
| B | LEU265 |
| B | ALA283 |
| B | GLN201 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | ACT_SITE: Proton donor; for uridylate-specific endoribonuclease nsp15 activity => ECO:0000269|PubMed:33504779, ECO:0000269|PubMed:33564093 |
| Chain | Residue | Details |
| A | HIS234 | |
| B | HIS234 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | ACT_SITE: Proton acceptor; for uridylate-specific endoribonuclease nsp15 activity => ECO:0000269|PubMed:33504779, ECO:0000269|PubMed:33564093 |
| Chain | Residue | Details |
| A | HIS249 | |
| B | HIS249 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | ACT_SITE: For uridylate-specific endoribonuclease nsp15 activity => ECO:0000269|PubMed:33504779 |
| Chain | Residue | Details |
| A | LYS289 | |
| B | LYS289 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:33504779, ECO:0000269|PubMed:33564093 |
| Chain | Residue | Details |
| A | LYS289 | |
| B | LYS289 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:33564093 |
| Chain | Residue | Details |
| A | THR340 | |
| B | THR340 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | SITE: Transition state stabilizer => ECO:0000269|PubMed:33504779, ECO:0000269|PubMed:33564093 |
| Chain | Residue | Details |
| A | LYS289 | |
| B | LYS289 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | SITE: Uracil recognition site => ECO:0000269|PubMed:33504779, ECO:0000269|PubMed:33564093 |
| Chain | Residue | Details |
| A | SER293 | |
| B | SER293 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 2 |
| Details | SITE: Cleavage; by 3CL-PRO => ECO:0000250|UniProtKB:P0C6V3 |
| Chain | Residue | Details |
| A | GLN346 | |
| B | GLN346 |
