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5S9P

CRYSTAL STRUCTURE OF THE FIRST BROMODOMAIN OF HUMAN BRD4 IN COMPLEX WITH 9-benzyl-2-(3,5-dimethyl-1,2-oxazol-4-yl)-7-(2-hydroxypropan-2-yl)-9H-carbazole-4-carboxamide

Functional Information from PDB Data
site_idAC1
Number of Residues13
Detailsbinding site for residue YW4 A 301
ChainResidue
ATRP81
AHOH402
DGLN78
DPHE79
DASP145
APRO82
APHE83
AGLN85
APRO86
AASP88
ALEU92
AASN140
AMET149

site_idAC2
Number of Residues15
Detailsbinding site for residue YW4 B 301
ChainResidue
BTRP81
BPRO82
BPHE83
BGLN85
BPRO86
BASP88
BLEU92
BASN140
BILE146
BHOH401
EHIS77
EGLN78
EPHE79
ELEU148
EHOH412

site_idAC3
Number of Residues10
Detailsbinding site for residue YW4 D 301
ChainResidue
DTRP81
DPRO82
DPHE83
DGLN85
DPRO86
DASP88
DLEU92
DASN140
DMET149
DHOH402

site_idAC4
Number of Residues6
Detailsbinding site for residue EDO D 302
ChainResidue
DILE100
DLYS102
DTHR103
DASN135
DHOH411
EASN116

site_idAC5
Number of Residues11
Detailsbinding site for residue YW4 E 301
ChainResidue
ETRP81
EPRO82
EPHE83
EGLN85
EPRO86
EASP88
ELEU92
EASN140
EILE146
EMET149
EHOH402

site_idAC6
Number of Residues5
Detailsbinding site for residue EDO E 302
ChainResidue
DHOH410
ETRP75
EHIS77
EGLN84
EHOH424

Functional Information from PROSITE/UniProt
site_idPS00633
Number of Residues60
DetailsBROMODOMAIN_1 Bromodomain signature. AwpFqqpvDavklnlpDYYkiIktpMdmgtIkkrlenny..Ywnaqeciqdfnt.MftNCyiY
ChainResidueDetails
AALA80-TYR139

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues424
DetailsDomain: {"description":"Bromo 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00035","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues4
DetailsSite: {"description":"Acetylated histone binding","evidences":[{"source":"PubMed","id":"22464331","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI3
Number of Residues8
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

245663

PDB entries from 2025-12-03

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