5S8H

XChem group deposition -- Crystal Structure of the second bromodomain of pleckstrin homology domain interacting protein (PHIP) in complex with N00964e (space group C2)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005158	molecular_function	insulin receptor binding
A	0008286	biological_process	insulin receptor signaling pathway

Functional Information from PDB Data

site_id	AC1
Number of Residues	10
Details	binding site for residue D4V A 1501

Chain	Residue
A	PRO1340
A	HOH1696
A	PHE1341
A	VAL1345
A	TYR1350
A	SER1392
A	TYR1395
A	ILE1403
A	HOH1607
A	HOH1681

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Functional Information from PROSITE/UniProt

site_id	PS00633
Number of Residues	58
Details	BROMODOMAIN_1 Bromodomain signature. SepFrqpvDlleyp..DYRdiIdtpMdfatVretleagn..Yespmelckdvrl.IfsNSkaY

Chain	Residue	Details
A	SER1338-TYR1395

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569

Chain	Residue	Details
A	SER1315

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site_id	SWS_FT_FI2
Number of Residues	1
Details	MOD_RES: Phosphothreonine => ECO:0007744|PubMed:20068231

Chain	Residue	Details
A	THR1359

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site_id	SWS_FT_FI3
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:20068231

Chain	Residue	Details
A	SER1405

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