5S8D

XChem group deposition -- Crystal Structure of the second bromodomain of pleckstrin homology domain interacting protein (PHIP) in complex with N00539e (space group C2)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005158	molecular_function	insulin receptor binding
A	0008286	biological_process	insulin receptor signaling pathway

Functional Information from PDB Data

site_id	AC1
Number of Residues	8
Details	binding site for residue N1E A 1501

Chain	Residue
A	SER1392
A	THR1396
A	PRO1397
A	SER1401
A	ILE1403
A	HOH1603
A	HOH1682
A	HOH1690

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Functional Information from PROSITE/UniProt

site_id	PS00633
Number of Residues	58
Details	BROMODOMAIN_1 Bromodomain signature. SepFrqpvDlleyp..DYRdiIdtpMdfatVretleagn..Yespmelckdvrl.IfsNSkaY

Chain	Residue	Details
A	SER1338-TYR1395

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	105
Details	Domain: {"description":"Bromo 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00035","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	1
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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