Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004672 | molecular_function | protein kinase activity |
A | 0004675 | molecular_function | transmembrane receptor protein serine/threonine kinase activity |
A | 0005524 | molecular_function | ATP binding |
A | 0006468 | biological_process | protein phosphorylation |
A | 0007178 | biological_process | cell surface receptor protein serine/threonine kinase signaling pathway |
A | 0016020 | cellular_component | membrane |
B | 0004672 | molecular_function | protein kinase activity |
B | 0004675 | molecular_function | transmembrane receptor protein serine/threonine kinase activity |
B | 0005524 | molecular_function | ATP binding |
B | 0006468 | biological_process | protein phosphorylation |
B | 0007178 | biological_process | cell surface receptor protein serine/threonine kinase signaling pathway |
B | 0016020 | cellular_component | membrane |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 15 |
Details | binding site for residue LU8 A 501 |
Chain | Residue |
A | VAL214 |
A | ASN341 |
A | LEU343 |
A | ALA353 |
A | ASP354 |
A | HOH602 |
A | HOH741 |
A | ALA233 |
A | LYS235 |
A | LEU281 |
A | THR283 |
A | TYR285 |
A | HIS286 |
A | GLY289 |
A | LYS340 |
site_id | AC2 |
Number of Residues | 7 |
Details | binding site for residue EDO A 502 |
Chain | Residue |
A | HIS259 |
A | GLU260 |
A | ILE262 |
A | LEU263 |
A | GLY264 |
A | HIS284 |
A | HIS286 |
site_id | AC3 |
Number of Residues | 7 |
Details | binding site for residue EDO A 503 |
Chain | Residue |
A | PHE431 |
A | ASP433 |
A | GLN453 |
A | ARG454 |
A | ASN456 |
A | HOH694 |
A | HOH729 |
site_id | AC4 |
Number of Residues | 4 |
Details | binding site for residue EDO A 504 |
Chain | Residue |
A | ARG445 |
A | HOH657 |
A | HOH844 |
A | HOH888 |
site_id | AC5 |
Number of Residues | 6 |
Details | binding site for residue EDO A 505 |
Chain | Residue |
A | ARG380 |
A | TYR432 |
A | VAL435 |
A | PRO436 |
A | ASN437 |
B | ASN437 |
site_id | AC6 |
Number of Residues | 2 |
Details | binding site for residue TLA A 506 |
Chain | Residue |
A | ARG273 |
A | HIS274 |
site_id | AC7 |
Number of Residues | 15 |
Details | binding site for residue LU8 A 507 |
Chain | Residue |
A | ARG202 |
A | VAL204 |
A | ALA205 |
A | ARG206 |
A | TRP227 |
A | ALA267 |
A | LU8508 |
A | EDO513 |
A | EDO514 |
A | HOH720 |
A | HOH769 |
B | ASP269 |
B | THR271 |
B | GLN278 |
B | TRP280 |
site_id | AC8 |
Number of Residues | 12 |
Details | binding site for residue LU8 A 508 |
Chain | Residue |
A | TRP227 |
A | GLU230 |
A | ILE266 |
A | ASN459 |
A | PHE462 |
A | SER463 |
A | LU8507 |
A | XK1509 |
A | EDO514 |
A | HOH640 |
B | SER272 |
B | HOH757 |
site_id | AC9 |
Number of Residues | 4 |
Details | binding site for residue XK1 A 509 |
Chain | Residue |
A | GLU230 |
A | HIS284 |
A | LU8508 |
A | HOH611 |
site_id | AD1 |
Number of Residues | 8 |
Details | binding site for residue SO4 A 510 |
Chain | Residue |
A | PRO458 |
A | ASN459 |
A | HOH661 |
A | HOH747 |
A | HOH760 |
A | HOH802 |
A | HOH852 |
B | HIS274 |
site_id | AD2 |
Number of Residues | 9 |
Details | binding site for residue SO4 A 511 |
Chain | Residue |
A | ARG380 |
A | ASP438 |
A | PRO439 |
A | HOH655 |
A | HOH711 |
A | HOH755 |
A | HOH775 |
A | HOH776 |
A | HOH820 |
site_id | AD3 |
Number of Residues | 9 |
Details | binding site for residue EDO A 512 |
Chain | Residue |
A | VAL255 |
A | MET256 |
A | LEU257 |
A | ARG258 |
A | HIS318 |
A | GLY328 |
A | HOH644 |
A | HOH773 |
A | HOH893 |
site_id | AD4 |
Number of Residues | 3 |
Details | binding site for residue EDO A 513 |
Chain | Residue |
A | ARG202 |
A | LU8507 |
A | GLN201 |
site_id | AD5 |
Number of Residues | 7 |
Details | binding site for residue EDO A 514 |
Chain | Residue |
A | ARG202 |
A | ASN421 |
A | ILE423 |
A | SER463 |
A | LU8507 |
A | LU8508 |
A | HOH663 |
site_id | AD6 |
Number of Residues | 3 |
Details | binding site for residue EDO A 515 |
Chain | Residue |
A | GLY217 |
A | ARG218 |
A | TYR219 |
site_id | AD7 |
Number of Residues | 4 |
Details | binding site for residue EDO A 516 |
Chain | Residue |
A | ARG416 |
A | TYR432 |
A | HOH606 |
A | HOH733 |
site_id | AD8 |
Number of Residues | 16 |
Details | binding site for residue LU8 B 501 |
Chain | Residue |
B | VAL214 |
B | ALA233 |
B | LYS235 |
B | GLU248 |
B | LEU281 |
B | THR283 |
B | TYR285 |
B | HIS286 |
B | GLY289 |
B | ASP293 |
B | PHE324 |
B | LYS340 |
B | ASN341 |
B | LEU343 |
B | ALA353 |
B | HOH825 |
site_id | AD9 |
Number of Residues | 9 |
Details | binding site for residue SO4 B 502 |
Chain | Residue |
B | HIS286 |
B | LYS345 |
B | LYS346 |
B | HOH605 |
B | HOH688 |
B | HOH695 |
B | HOH740 |
B | HOH766 |
B | HOH831 |
site_id | AE1 |
Number of Residues | 7 |
Details | binding site for residue EDO B 503 |
Chain | Residue |
B | ASP433 |
B | VAL434 |
B | GLN453 |
B | ARG454 |
B | ASN456 |
B | HOH666 |
B | HOH760 |
site_id | AE2 |
Number of Residues | 2 |
Details | binding site for residue DMS B 504 |
Chain | Residue |
B | ARG490 |
B | LYS493 |
site_id | AE3 |
Number of Residues | 4 |
Details | binding site for residue SO4 B 505 |
Chain | Residue |
B | GLY217 |
B | ARG218 |
B | TYR219 |
B | HOH634 |
site_id | AE4 |
Number of Residues | 6 |
Details | binding site for residue SO4 B 506 |
Chain | Residue |
B | THR378 |
B | LYS379 |
B | HOH620 |
B | HOH661 |
B | HOH817 |
B | HOH824 |
site_id | AE5 |
Number of Residues | 9 |
Details | binding site for residue EDO B 507 |
Chain | Residue |
B | HIS259 |
B | GLU260 |
B | ILE262 |
B | LEU263 |
B | GLY264 |
B | HIS284 |
B | HIS286 |
B | CYS351 |
B | HOH846 |
site_id | AE6 |
Number of Residues | 4 |
Details | binding site for residue EDO B 508 |
Chain | Residue |
B | TYR479 |
B | GLN480 |
B | ASN481 |
B | HOH762 |
site_id | AE7 |
Number of Residues | 3 |
Details | binding site for residue EDO B 509 |
Chain | Residue |
B | VAL419 |
B | GLY422 |
B | HOH709 |
Functional Information from PROSITE/UniProt
site_id | PS00107 |
Number of Residues | 22 |
Details | PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. VGKGRYGEVWrGswqgen............VAVK |
Chain | Residue | Details |
A | VAL214-LYS235 | |
site_id | PS00108 |
Number of Residues | 13 |
Details | PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. IaHrDLKskNILV |
Chain | Residue | Details |
A | ILE332-VAL344 | |
Functional Information from SwissProt/UniProt
Chain | Residue | Details |
A | ASP336 | |
B | ASP336 | |
Chain | Residue | Details |
A | VAL214 | |
A | LYS235 | |
B | VAL214 | |
B | LYS235 | |