Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004672 | molecular_function | protein kinase activity |
| A | 0004675 | molecular_function | transmembrane receptor protein serine/threonine kinase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0006468 | biological_process | protein phosphorylation |
| A | 0007178 | biological_process | cell surface receptor protein serine/threonine kinase signaling pathway |
| A | 0016020 | cellular_component | membrane |
| B | 0004672 | molecular_function | protein kinase activity |
| B | 0004675 | molecular_function | transmembrane receptor protein serine/threonine kinase activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0006468 | biological_process | protein phosphorylation |
| B | 0007178 | biological_process | cell surface receptor protein serine/threonine kinase signaling pathway |
| B | 0016020 | cellular_component | membrane |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 18 |
| Details | binding site for residue LU8 A 501 |
| Chain | Residue |
| A | GLU212 |
| A | ASP293 |
| A | LYS340 |
| A | ASN341 |
| A | LEU343 |
| A | ALA353 |
| A | ASP354 |
| A | HOH601 |
| A | HOH710 |
| A | HOH777 |
| A | VAL214 |
| A | ALA233 |
| A | LYS235 |
| A | LEU281 |
| A | THR283 |
| A | TYR285 |
| A | HIS286 |
| A | GLY289 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | binding site for residue EDO A 502 |
| Chain | Residue |
| A | HIS259 |
| A | GLU260 |
| A | ILE262 |
| A | GLY264 |
| A | HIS284 |
| A | HIS286 |
| A | CYS351 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | binding site for residue EDO A 503 |
| Chain | Residue |
| A | PHE431 |
| A | ASP433 |
| A | GLN453 |
| A | ARG454 |
| A | ASN456 |
| A | HOH724 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | binding site for residue EDO A 504 |
| Chain | Residue |
| A | ARG445 |
| A | VAL450 |
| A | HOH602 |
| A | HOH630 |
| A | HOH815 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | binding site for residue EDO A 505 |
| Chain | Residue |
| A | ARG380 |
| A | TYR432 |
| A | VAL435 |
| A | PRO436 |
| A | ASN437 |
| B | ASN437 |
| site_id | AC6 |
| Number of Residues | 3 |
| Details | binding site for residue DMS A 506 |
| Chain | Residue |
| B | ARG273 |
| B | HIS274 |
| B | HOH678 |
| site_id | AC7 |
| Number of Residues | 11 |
| Details | binding site for residue LU8 A 507 |
| Chain | Residue |
| A | VAL204 |
| A | ALA205 |
| A | ARG206 |
| A | TRP227 |
| A | LU8508 |
| A | EDO514 |
| A | HOH686 |
| B | ASP269 |
| B | THR271 |
| B | GLN278 |
| B | TRP280 |
| site_id | AC8 |
| Number of Residues | 12 |
| Details | binding site for residue LU8 A 508 |
| Chain | Residue |
| A | TRP227 |
| A | ILE266 |
| A | ILE423 |
| A | ASN459 |
| A | PHE462 |
| A | SER463 |
| A | LU8507 |
| A | HOH816 |
| B | SER272 |
| B | ARG273 |
| B | SER276 |
| B | HOH727 |
| site_id | AC9 |
| Number of Residues | 7 |
| Details | binding site for residue XHJ A 509 |
| Chain | Residue |
| A | ARG307 |
| A | LEU310 |
| A | SER311 |
| A | GLN349 |
| A | HOH619 |
| A | HOH624 |
| A | HOH749 |
| site_id | AD1 |
| Number of Residues | 7 |
| Details | binding site for residue SO4 A 510 |
| Chain | Residue |
| A | ASN456 |
| A | PRO458 |
| A | ASN459 |
| A | HOH698 |
| A | HOH844 |
| B | HIS274 |
| B | HOH726 |
| site_id | AD2 |
| Number of Residues | 9 |
| Details | binding site for residue SO4 A 511 |
| Chain | Residue |
| A | ARG380 |
| A | ASP438 |
| A | PRO439 |
| A | HOH660 |
| A | HOH727 |
| A | HOH731 |
| A | HOH753 |
| A | HOH772 |
| A | HOH819 |
| site_id | AD3 |
| Number of Residues | 9 |
| Details | binding site for residue SO4 A 512 |
| Chain | Residue |
| A | HOH790 |
| A | HIS286 |
| A | LYS345 |
| A | LYS346 |
| A | HOH607 |
| A | HOH643 |
| A | HOH684 |
| A | HOH701 |
| A | HOH783 |
| site_id | AD4 |
| Number of Residues | 7 |
| Details | binding site for residue EDO A 513 |
| Chain | Residue |
| A | MET256 |
| A | LEU257 |
| A | ARG258 |
| A | HIS318 |
| A | HOH605 |
| A | HOH651 |
| A | HOH705 |
| site_id | AD5 |
| Number of Residues | 5 |
| Details | binding site for residue EDO A 514 |
| Chain | Residue |
| A | ASN421 |
| A | ILE423 |
| A | SER463 |
| A | LU8507 |
| A | HOH650 |
| site_id | AD6 |
| Number of Residues | 3 |
| Details | binding site for residue EDO A 515 |
| Chain | Residue |
| A | GLY217 |
| A | ARG218 |
| A | TYR219 |
| site_id | AD7 |
| Number of Residues | 5 |
| Details | binding site for residue EDO A 516 |
| Chain | Residue |
| A | ARG416 |
| A | LYS428 |
| A | TYR432 |
| A | HOH612 |
| A | HOH825 |
| site_id | AD8 |
| Number of Residues | 16 |
| Details | binding site for residue LU8 B 501 |
| Chain | Residue |
| B | VAL214 |
| B | ALA233 |
| B | LYS235 |
| B | GLU248 |
| B | LEU281 |
| B | THR283 |
| B | TYR285 |
| B | HIS286 |
| B | GLY289 |
| B | ASP293 |
| B | LYS340 |
| B | ASN341 |
| B | LEU343 |
| B | ALA353 |
| B | XHJ506 |
| B | HOH832 |
| site_id | AD9 |
| Number of Residues | 9 |
| Details | binding site for residue SO4 B 502 |
| Chain | Residue |
| B | HIS286 |
| B | LYS345 |
| B | LYS346 |
| B | HOH618 |
| B | HOH669 |
| B | HOH703 |
| B | HOH704 |
| B | HOH721 |
| B | HOH822 |
| site_id | AE1 |
| Number of Residues | 8 |
| Details | binding site for residue EDO B 503 |
| Chain | Residue |
| B | ASP433 |
| B | VAL434 |
| B | GLN453 |
| B | ARG454 |
| B | ASN456 |
| B | HOH672 |
| B | HOH697 |
| B | HOH790 |
| site_id | AE2 |
| Number of Residues | 2 |
| Details | binding site for residue DMS B 504 |
| Chain | Residue |
| B | ARG490 |
| B | LYS493 |
| site_id | AE3 |
| Number of Residues | 6 |
| Details | binding site for residue XHJ B 505 |
| Chain | Residue |
| B | ARG335 |
| B | VAL370 |
| B | TYR399 |
| B | HOH602 |
| B | HOH673 |
| B | HOH865 |
| site_id | AE4 |
| Number of Residues | 7 |
| Details | binding site for residue XHJ B 506 |
| Chain | Residue |
| B | GLU212 |
| B | VAL214 |
| B | TYR285 |
| B | PHE324 |
| B | GLN363 |
| B | LU8501 |
| B | HOH948 |
| site_id | AE5 |
| Number of Residues | 10 |
| Details | binding site for residue XHJ B 507 |
| Chain | Residue |
| B | MET288 |
| B | TYR294 |
| B | SER304 |
| B | LYS345 |
| B | LYS346 |
| B | GLY348 |
| B | HOH628 |
| B | HOH642 |
| B | HOH715 |
| B | HOH760 |
| site_id | AE6 |
| Number of Residues | 8 |
| Details | binding site for residue XHJ B 508 |
| Chain | Residue |
| B | TYR252 |
| B | ARG258 |
| B | LEU263 |
| B | GLY264 |
| B | PHE265 |
| B | HOH601 |
| B | HOH603 |
| B | HOH607 |
| site_id | AE7 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 B 509 |
| Chain | Residue |
| B | THR378 |
| B | LYS379 |
| B | HOH604 |
| B | HOH608 |
| B | HOH779 |
| site_id | AE8 |
| Number of Residues | 8 |
| Details | binding site for residue EDO B 510 |
| Chain | Residue |
| B | HIS259 |
| B | GLU260 |
| B | ILE262 |
| B | GLY264 |
| B | HIS284 |
| B | HIS286 |
| B | CYS351 |
| B | HOH635 |
| site_id | AE9 |
| Number of Residues | 4 |
| Details | binding site for residue EDO B 511 |
| Chain | Residue |
| A | HOH774 |
| B | VAL419 |
| B | GLY422 |
| B | HOH831 |
Functional Information from PROSITE/UniProt
| site_id | PS00107 |
| Number of Residues | 22 |
| Details | PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. VGKGRYGEVWrGswqgen............VAVK |
| Chain | Residue | Details |
| A | VAL214-LYS235 | |
| site_id | PS00108 |
| Number of Residues | 13 |
| Details | PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. IaHrDLKskNILV |
| Chain | Residue | Details |
| A | ILE332-VAL344 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10027","evidenceCode":"ECO:0000255"}]} |
| site_id | SWS_FT_FI2 |
| Number of Residues | 18 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]} |
