Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004672 | molecular_function | protein kinase activity |
| A | 0004675 | molecular_function | transmembrane receptor protein serine/threonine kinase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0006468 | biological_process | protein phosphorylation |
| A | 0007178 | biological_process | cell surface receptor protein serine/threonine kinase signaling pathway |
| A | 0016020 | cellular_component | membrane |
| B | 0004672 | molecular_function | protein kinase activity |
| B | 0004675 | molecular_function | transmembrane receptor protein serine/threonine kinase activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0006468 | biological_process | protein phosphorylation |
| B | 0007178 | biological_process | cell surface receptor protein serine/threonine kinase signaling pathway |
| B | 0016020 | cellular_component | membrane |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 19 |
| Details | binding site for residue LU8 A 501 |
| Chain | Residue |
| A | GLU212 |
| A | GLY289 |
| A | ASP293 |
| A | LYS340 |
| A | ASN341 |
| A | LEU343 |
| A | ALA353 |
| A | ASP354 |
| A | HOH648 |
| A | HOH737 |
| A | HOH848 |
| A | VAL214 |
| A | VAL222 |
| A | ALA233 |
| A | LYS235 |
| A | LEU281 |
| A | THR283 |
| A | TYR285 |
| A | HIS286 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | binding site for residue EDO A 502 |
| Chain | Residue |
| A | HIS259 |
| A | GLU260 |
| A | ILE262 |
| A | LEU263 |
| A | GLY264 |
| A | HIS284 |
| A | HIS286 |
| site_id | AC3 |
| Number of Residues | 7 |
| Details | binding site for residue EDO A 503 |
| Chain | Residue |
| A | PHE431 |
| A | ASP433 |
| A | GLN453 |
| A | ARG454 |
| A | ASN456 |
| A | HOH720 |
| A | HOH755 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | binding site for residue EDO A 504 |
| Chain | Residue |
| A | ARG445 |
| A | HOH742 |
| A | HOH877 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | binding site for residue EDO A 505 |
| Chain | Residue |
| A | ARG380 |
| A | TYR432 |
| A | VAL435 |
| A | PRO436 |
| A | ASN437 |
| B | ASN437 |
| site_id | AC6 |
| Number of Residues | 15 |
| Details | binding site for residue LU8 A 506 |
| Chain | Residue |
| A | ARG202 |
| A | VAL204 |
| A | ALA205 |
| A | ARG206 |
| A | TRP227 |
| A | ALA267 |
| A | LU8507 |
| A | EDO513 |
| A | EDO514 |
| A | HOH704 |
| B | ARG206 |
| B | ASP269 |
| B | THR271 |
| B | GLN278 |
| B | TRP280 |
| site_id | AC7 |
| Number of Residues | 12 |
| Details | binding site for residue LU8 A 507 |
| Chain | Residue |
| A | TRP227 |
| A | ILE266 |
| A | ASN459 |
| A | PHE462 |
| A | SER463 |
| A | LU8506 |
| A | XHG508 |
| A | EDO514 |
| A | HOH620 |
| B | SER272 |
| B | ARG273 |
| B | HOH757 |
| site_id | AC8 |
| Number of Residues | 7 |
| Details | binding site for residue XHG A 508 |
| Chain | Residue |
| A | ASN459 |
| A | LU8507 |
| A | DMS509 |
| A | HOH915 |
| B | HIS274 |
| B | SER275 |
| B | SER276 |
| site_id | AC9 |
| Number of Residues | 7 |
| Details | binding site for residue DMS A 509 |
| Chain | Residue |
| A | ASN456 |
| A | PRO458 |
| A | ASN459 |
| A | XHG508 |
| A | HOH957 |
| B | HIS274 |
| B | HOH938 |
| site_id | AD1 |
| Number of Residues | 8 |
| Details | binding site for residue SO4 A 510 |
| Chain | Residue |
| A | HIS286 |
| A | LYS345 |
| A | LYS346 |
| A | HOH616 |
| A | HOH673 |
| A | HOH697 |
| A | HOH698 |
| A | HOH771 |
| site_id | AD2 |
| Number of Residues | 9 |
| Details | binding site for residue SO4 A 511 |
| Chain | Residue |
| A | HOH809 |
| A | ARG380 |
| A | ASP438 |
| A | PRO439 |
| A | HOH656 |
| A | HOH724 |
| A | HOH734 |
| A | HOH766 |
| A | HOH805 |
| site_id | AD3 |
| Number of Residues | 8 |
| Details | binding site for residue EDO A 512 |
| Chain | Residue |
| A | VAL255 |
| A | MET256 |
| A | LEU257 |
| A | ARG258 |
| A | HIS318 |
| A | GLY328 |
| A | HOH641 |
| A | HOH787 |
| site_id | AD4 |
| Number of Residues | 3 |
| Details | binding site for residue EDO A 513 |
| Chain | Residue |
| A | GLN201 |
| A | ARG202 |
| A | LU8506 |
| site_id | AD5 |
| Number of Residues | 7 |
| Details | binding site for residue EDO A 514 |
| Chain | Residue |
| A | ARG202 |
| A | ASN421 |
| A | ILE423 |
| A | SER463 |
| A | LU8506 |
| A | LU8507 |
| A | HOH667 |
| site_id | AD6 |
| Number of Residues | 3 |
| Details | binding site for residue EDO A 515 |
| Chain | Residue |
| A | GLY217 |
| A | ARG218 |
| A | TYR219 |
| site_id | AD7 |
| Number of Residues | 4 |
| Details | binding site for residue EDO A 516 |
| Chain | Residue |
| A | ARG416 |
| A | TYR432 |
| A | HOH601 |
| A | HOH672 |
| site_id | AD8 |
| Number of Residues | 16 |
| Details | binding site for residue LU8 B 501 |
| Chain | Residue |
| B | VAL214 |
| B | ALA233 |
| B | LYS235 |
| B | GLU248 |
| B | LEU281 |
| B | THR283 |
| B | TYR285 |
| B | HIS286 |
| B | GLY289 |
| B | ASP293 |
| B | PHE324 |
| B | LYS340 |
| B | ASN341 |
| B | LEU343 |
| B | ALA353 |
| B | HOH848 |
| site_id | AD9 |
| Number of Residues | 8 |
| Details | binding site for residue SO4 B 502 |
| Chain | Residue |
| B | HIS286 |
| B | LYS345 |
| B | LYS346 |
| B | HOH667 |
| B | HOH683 |
| B | HOH696 |
| B | HOH755 |
| B | HOH826 |
| site_id | AE1 |
| Number of Residues | 8 |
| Details | binding site for residue EDO B 503 |
| Chain | Residue |
| B | PHE431 |
| B | ASP433 |
| B | VAL434 |
| B | GLN453 |
| B | ARG454 |
| B | ASN456 |
| B | HOH670 |
| B | HOH769 |
| site_id | AE2 |
| Number of Residues | 2 |
| Details | binding site for residue DMS B 504 |
| Chain | Residue |
| B | ARG490 |
| B | LYS493 |
| site_id | AE3 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 B 505 |
| Chain | Residue |
| B | GLY217 |
| B | ARG218 |
| B | TYR219 |
| B | HOH665 |
| site_id | AE4 |
| Number of Residues | 6 |
| Details | binding site for residue SO4 B 506 |
| Chain | Residue |
| B | THR378 |
| B | LYS379 |
| B | HOH602 |
| B | HOH607 |
| B | HOH775 |
| B | HOH779 |
| site_id | AE5 |
| Number of Residues | 6 |
| Details | binding site for residue EDO B 507 |
| Chain | Residue |
| B | HIS259 |
| B | GLU260 |
| B | ILE262 |
| B | GLY264 |
| B | HIS284 |
| B | HIS286 |
| site_id | AE6 |
| Number of Residues | 4 |
| Details | binding site for residue EDO B 508 |
| Chain | Residue |
| B | TYR479 |
| B | GLN480 |
| B | ASN481 |
| B | HOH721 |
| site_id | AE7 |
| Number of Residues | 2 |
| Details | binding site for residue EDO B 509 |
| Chain | Residue |
| B | VAL419 |
| B | GLY422 |
Functional Information from PROSITE/UniProt
| site_id | PS00107 |
| Number of Residues | 22 |
| Details | PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. VGKGRYGEVWrGswqgen............VAVK |
| Chain | Residue | Details |
| A | VAL214-LYS235 | |
| site_id | PS00108 |
| Number of Residues | 13 |
| Details | PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. IaHrDLKskNILV |
| Chain | Residue | Details |
| A | ILE332-VAL344 | |
Functional Information from SwissProt/UniProt
| Chain | Residue | Details |
| A | ASP336 | |
| B | ASP336 | |
| Chain | Residue | Details |
| B | VAL214 | |
| B | LYS235 | |
| A | LYS235 | |
| A | VAL214 | |
