Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004672 | molecular_function | protein kinase activity |
| A | 0004675 | molecular_function | transmembrane receptor protein serine/threonine kinase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0006468 | biological_process | protein phosphorylation |
| A | 0007178 | biological_process | cell surface receptor protein serine/threonine kinase signaling pathway |
| A | 0016020 | cellular_component | membrane |
| B | 0004672 | molecular_function | protein kinase activity |
| B | 0004675 | molecular_function | transmembrane receptor protein serine/threonine kinase activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0006468 | biological_process | protein phosphorylation |
| B | 0007178 | biological_process | cell surface receptor protein serine/threonine kinase signaling pathway |
| B | 0016020 | cellular_component | membrane |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 14 |
| Details | binding site for residue LU8 A 501 |
| Chain | Residue |
| A | VAL214 |
| A | ASN341 |
| A | LEU343 |
| A | ALA353 |
| A | HOH634 |
| A | HOH734 |
| A | ALA233 |
| A | LYS235 |
| A | LEU281 |
| A | THR283 |
| A | TYR285 |
| A | HIS286 |
| A | GLY289 |
| A | LYS340 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | binding site for residue EDO A 502 |
| Chain | Residue |
| A | HIS259 |
| A | ILE262 |
| A | LEU263 |
| A | GLY264 |
| A | HIS284 |
| A | HIS286 |
| site_id | AC3 |
| Number of Residues | 7 |
| Details | binding site for residue EDO A 503 |
| Chain | Residue |
| A | PHE431 |
| A | ASP433 |
| A | GLN453 |
| A | ARG454 |
| A | ASN456 |
| A | HOH699 |
| A | HOH704 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | binding site for residue EDO A 504 |
| Chain | Residue |
| A | VAL303 |
| A | ARG445 |
| A | VAL450 |
| A | HOH605 |
| A | HOH664 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | binding site for residue EDO A 505 |
| Chain | Residue |
| A | ARG380 |
| A | TYR432 |
| A | VAL435 |
| A | PRO436 |
| A | ASN437 |
| B | ASN437 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | binding site for residue DMS A 506 |
| Chain | Residue |
| A | HIS284 |
| A | HOH602 |
| A | HOH607 |
| A | HOH875 |
| B | ARG273 |
| B | HOH657 |
| site_id | AC7 |
| Number of Residues | 15 |
| Details | binding site for residue LU8 A 507 |
| Chain | Residue |
| A | ARG202 |
| A | VAL204 |
| A | ALA205 |
| A | ARG206 |
| A | ALA267 |
| A | LU8508 |
| A | EDO516 |
| A | EDO517 |
| A | HOH624 |
| A | HOH726 |
| B | ARG206 |
| B | ASP269 |
| B | THR271 |
| B | GLN278 |
| B | TRP280 |
| site_id | AC8 |
| Number of Residues | 14 |
| Details | binding site for residue LU8 A 508 |
| Chain | Residue |
| A | TRP227 |
| A | ILE266 |
| A | ASN459 |
| A | PHE462 |
| A | SER463 |
| A | LU8507 |
| A | HOH602 |
| A | HOH702 |
| B | SER272 |
| B | ARG273 |
| B | SER276 |
| B | HOH688 |
| B | HOH827 |
| B | HOH887 |
| site_id | AC9 |
| Number of Residues | 8 |
| Details | binding site for residue HV2 A 509 |
| Chain | Residue |
| A | GLY215 |
| A | LYS216 |
| A | GLY217 |
| A | ARG218 |
| A | TYR219 |
| A | GLY220 |
| A | GLU221 |
| A | LYS235 |
| site_id | AD1 |
| Number of Residues | 7 |
| Details | binding site for residue HV2 A 510 |
| Chain | Residue |
| A | TYR294 |
| A | THR298 |
| A | THR299 |
| A | LEU300 |
| A | ASP301 |
| A | SER304 |
| A | HOH728 |
| site_id | AD2 |
| Number of Residues | 6 |
| Details | binding site for residue HV2 A 511 |
| Chain | Residue |
| A | SER483 |
| A | ALA484 |
| A | ARG485 |
| A | LEU486 |
| A | THR487 |
| A | ARG490 |
| site_id | AD3 |
| Number of Residues | 9 |
| Details | binding site for residue SO4 A 512 |
| Chain | Residue |
| A | HOH651 |
| A | HOH681 |
| A | HOH683 |
| A | HOH794 |
| A | HIS284 |
| A | HIS286 |
| A | LYS345 |
| A | LYS346 |
| A | HOH619 |
| site_id | AD4 |
| Number of Residues | 8 |
| Details | binding site for residue SO4 A 513 |
| Chain | Residue |
| A | ASN456 |
| A | PRO458 |
| A | ASN459 |
| A | HOH655 |
| A | HOH692 |
| A | HOH770 |
| A | HOH779 |
| B | HIS274 |
| site_id | AD5 |
| Number of Residues | 9 |
| Details | binding site for residue SO4 A 514 |
| Chain | Residue |
| A | ARG380 |
| A | ASP438 |
| A | PRO439 |
| A | HOH644 |
| A | HOH712 |
| A | HOH749 |
| A | HOH755 |
| A | HOH756 |
| A | HOH785 |
| site_id | AD6 |
| Number of Residues | 5 |
| Details | binding site for residue EDO A 515 |
| Chain | Residue |
| A | LEU257 |
| A | ARG258 |
| A | HIS318 |
| A | GLY328 |
| A | HOH693 |
| site_id | AD7 |
| Number of Residues | 4 |
| Details | binding site for residue EDO A 516 |
| Chain | Residue |
| A | GLN201 |
| A | ARG202 |
| A | LU8507 |
| B | ILE236 |
| site_id | AD8 |
| Number of Residues | 6 |
| Details | binding site for residue EDO A 517 |
| Chain | Residue |
| A | ARG202 |
| A | ASN421 |
| A | ILE423 |
| A | SER463 |
| A | LU8507 |
| A | HOH667 |
| site_id | AD9 |
| Number of Residues | 2 |
| Details | binding site for residue EDO A 518 |
| Chain | Residue |
| A | GLY217 |
| A | ARG218 |
| site_id | AE1 |
| Number of Residues | 4 |
| Details | binding site for residue EDO A 519 |
| Chain | Residue |
| A | ARG416 |
| A | TYR432 |
| A | HOH654 |
| A | HOH819 |
| site_id | AE2 |
| Number of Residues | 13 |
| Details | binding site for residue LU8 B 501 |
| Chain | Residue |
| B | VAL214 |
| B | ALA233 |
| B | LYS235 |
| B | GLU248 |
| B | LEU281 |
| B | THR283 |
| B | TYR285 |
| B | HIS286 |
| B | GLY289 |
| B | ASP293 |
| B | LYS340 |
| B | ASN341 |
| B | LEU343 |
| site_id | AE3 |
| Number of Residues | 9 |
| Details | binding site for residue SO4 B 502 |
| Chain | Residue |
| B | HIS286 |
| B | LYS345 |
| B | LYS346 |
| B | HOH640 |
| B | HOH661 |
| B | HOH700 |
| B | HOH710 |
| B | HOH731 |
| B | HOH826 |
| site_id | AE4 |
| Number of Residues | 10 |
| Details | binding site for residue EDO B 503 |
| Chain | Residue |
| B | PHE431 |
| B | ASP433 |
| B | VAL434 |
| B | GLN453 |
| B | ARG454 |
| B | ASN456 |
| B | HV2510 |
| B | HOH604 |
| B | HOH741 |
| B | HOH799 |
| site_id | AE5 |
| Number of Residues | 2 |
| Details | binding site for residue DMS B 504 |
| Chain | Residue |
| B | ARG490 |
| B | LYS493 |
| site_id | AE6 |
| Number of Residues | 4 |
| Details | binding site for residue HV2 B 505 |
| Chain | Residue |
| A | HOH653 |
| B | GLU389 |
| B | PHE441 |
| B | HOH601 |
| site_id | AE7 |
| Number of Residues | 8 |
| Details | binding site for residue HV2 B 506 |
| Chain | Residue |
| B | GLY215 |
| B | LYS216 |
| B | GLY220 |
| B | GLU221 |
| B | VAL222 |
| B | LYS235 |
| B | HOH602 |
| B | HOH647 |
| site_id | AE8 |
| Number of Residues | 9 |
| Details | binding site for residue HV2 B 507 |
| Chain | Residue |
| B | HIS361 |
| B | ASN366 |
| B | GLN367 |
| B | LEU368 |
| B | ASP394 |
| B | CYS395 |
| B | PHE396 |
| B | HOH658 |
| B | HOH752 |
| site_id | AE9 |
| Number of Residues | 5 |
| Details | binding site for residue HV2 B 508 |
| Chain | Residue |
| A | LYS243 |
| A | PHE246 |
| A | ARG247 |
| A | GLU250 |
| B | HV2509 |
| site_id | AF1 |
| Number of Residues | 7 |
| Details | binding site for residue HV2 B 509 |
| Chain | Residue |
| A | GLU242 |
| A | LYS243 |
| A | PHE246 |
| B | GLU250 |
| B | MET360 |
| B | HV2508 |
| B | HOH696 |
| site_id | AF2 |
| Number of Residues | 7 |
| Details | binding site for residue HV2 B 510 |
| Chain | Residue |
| B | GLN452 |
| B | GLN453 |
| B | ARG454 |
| B | ASN456 |
| B | PHE462 |
| B | EDO503 |
| B | HOH604 |
| site_id | AF3 |
| Number of Residues | 5 |
| Details | binding site for residue HV2 B 511 |
| Chain | Residue |
| B | GLN296 |
| B | ARG417 |
| B | ASP426 |
| B | TYR427 |
| B | HOH637 |
| site_id | AF4 |
| Number of Residues | 7 |
| Details | binding site for residue HV2 B 512 |
| Chain | Residue |
| B | TYR294 |
| B | THR298 |
| B | THR299 |
| B | LEU300 |
| B | ASP301 |
| B | SER304 |
| B | HOH754 |
| site_id | AF5 |
| Number of Residues | 7 |
| Details | binding site for residue HV2 B 513 |
| Chain | Residue |
| A | GLU389 |
| A | PHE441 |
| B | THR302 |
| B | SER420 |
| B | ASN421 |
| B | ASP464 |
| B | HOH746 |
| site_id | AF6 |
| Number of Residues | 8 |
| Details | binding site for residue EDO B 514 |
| Chain | Residue |
| B | HIS259 |
| B | GLU260 |
| B | ILE262 |
| B | LEU263 |
| B | GLY264 |
| B | HIS284 |
| B | HIS286 |
| B | HOH824 |
| site_id | AF7 |
| Number of Residues | 4 |
| Details | binding site for residue EDO B 515 |
| Chain | Residue |
| B | TYR479 |
| B | GLN480 |
| B | ASN481 |
| B | HOH646 |
| site_id | AF8 |
| Number of Residues | 3 |
| Details | binding site for residue EDO B 516 |
| Chain | Residue |
| B | TYR292 |
| B | GLN296 |
| B | PRO429 |
| site_id | AF9 |
| Number of Residues | 3 |
| Details | binding site for residue EDO B 517 |
| Chain | Residue |
| B | LYS428 |
| B | PRO429 |
| B | HOH642 |
| site_id | AG1 |
| Number of Residues | 3 |
| Details | binding site for residue EDO B 518 |
| Chain | Residue |
| B | VAL419 |
| B | GLY422 |
| B | HOH743 |
Functional Information from PROSITE/UniProt
| site_id | PS00107 |
| Number of Residues | 22 |
| Details | PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. VGKGRYGEVWrGswqgen............VAVK |
| Chain | Residue | Details |
| A | VAL214-LYS235 | |
| site_id | PS00108 |
| Number of Residues | 13 |
| Details | PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. IaHrDLKskNILV |
| Chain | Residue | Details |
| A | ILE332-VAL344 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10027","evidenceCode":"ECO:0000255"}]} |
| site_id | SWS_FT_FI2 |
| Number of Residues | 18 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]} |
