5RX4

INPP5D PanDDA analysis group deposition -- Crystal Structure of the phosphatase and C2 domains of SHIP1 in complex with Z1593306637

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0016791	molecular_function	phosphatase activity
A	0046856	biological_process	phosphatidylinositol dephosphorylation

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	binding site for residue H0D A 901

Chain	Residue
A	TYR440
A	GLU470
A	ILE471
A	THR472
A	LEU620
A	ARG624

---

site_id	AC2
Number of Residues	5
Details	binding site for residue H0D A 902

Chain	Residue
A	ILE504
A	LYS718
A	THR478
A	VAL479
A	GLU498

---

site_id	AC3
Number of Residues	7
Details	binding site for residue DMS A 903

Chain	Residue
A	GLY531
A	THR532
A	THR579
A	THR712
A	ASP798
A	GLN799
A	HOH1219

---

site_id	AC4
Number of Residues	6
Details	binding site for residue DMS A 904

Chain	Residue
A	TYR679
A	SER753
A	SER754
A	HIS800
A	LEU802
A	HOH1155

---

site_id	AC5
Number of Residues	5
Details	binding site for residue DMS A 905

Chain	Residue
A	HIS576
A	HIS631
A	CYS818
A	THR834
A	HOH1173

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	316
Details	Domain: {"description":"5-PPase","evidences":[{"source":"PROSITE-ProRule","id":"PRU01427","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU01427","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU01427","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---