5RHV

PanDDA analysis group deposition -- Crystal Structure of Zika virus NS3 Helicase in complex with Z62645406

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004386	molecular_function	helicase activity
A	0005524	molecular_function	ATP binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	2
Details	binding site for residue EDO A 701

Chain	Residue
A	ARG388
A	HOH869

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site_id	AC2
Number of Residues	11
Details	binding site for residue PO4 A 702

Chain	Residue
A	HOH806
A	HOH812
A	HOH835
A	HOH1011
A	HIS195
A	GLY197
A	ALA198
A	GLY199
A	LYS200
A	THR201
A	ARG462

---

site_id	AC3
Number of Residues	3
Details	binding site for residue PO4 A 703

Chain	Residue
A	HOH802
A	HOH846
A	HOH885

---

site_id	AC4
Number of Residues	4
Details	binding site for residue MPD A 704

Chain	Residue
A	ALA264
A	SER268
A	MET536
A	LYS537

---

site_id	AC5
Number of Residues	4
Details	binding site for residue UR4 A 705

Chain	Residue
A	PRO445
A	MET446
A	PRO447
A	ALA478

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00541

Chain	Residue	Details
A	LEU194

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site_id	SWS_FT_FI2
Number of Residues	2
Details	SITE: Involved in NS3 ATPase and RTPase activities => ECO:0000250|UniProtKB:P14335

Chain	Residue	Details
A	ARG456
A	ARG459

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	SITE: Cleavage; by autolysis => ECO:0000250|UniProtKB:P06935

Chain	Residue	Details
A	ARG617

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site_id	SWS_FT_FI4
Number of Residues	1
Details	MOD_RES: N6-acetyllysine; by host => ECO:0000269|PubMed:37478852

Chain	Residue	Details
A	LYS389

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