5RHH

PanDDA analysis group deposition -- Crystal Structure of Zika virus NS3 Helicase in complex with Z1515654336

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004386	molecular_function	helicase activity
A	0005524	molecular_function	ATP binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	1
Details	binding site for residue EDO A 701

Chain	Residue
A	HOH1079

---

site_id	AC2
Number of Residues	11
Details	binding site for residue PO4 A 702

Chain	Residue
A	HOH853
A	HOH908
A	HOH1046
A	HIS195
A	GLY197
A	ALA198
A	GLY199
A	LYS200
A	THR201
A	ARG462
A	HOH828

---

site_id	AC3
Number of Residues	3
Details	binding site for residue PO4 A 703

Chain	Residue
A	HOH813
A	HOH841
A	HOH855

---

site_id	AC4
Number of Residues	4
Details	binding site for residue MPD A 704

Chain	Residue
A	ALA264
A	SER268
A	MET536
A	LYS537

---

site_id	AC5
Number of Residues	11
Details	binding site for residue UQJ A 705

Chain	Residue
A	GLN500
A	TRP581
A	THR582
A	LYS583
A	TYR584
A	GLY585
A	ALA614
A	HOH801
A	HOH802
A	HOH1038
A	HOH1065

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	179
Details	Domain: {"description":"Helicase C-terminal","evidences":[{"source":"PROSITE-ProRule","id":"PRU00542","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	3
Details	Region: {"description":"Important for RNA-binding","evidences":[{"source":"UniProtKB","id":"P14340","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	3
Details	Motif: {"description":"DEAH box","evidences":[{"source":"PROSITE-ProRule","id":"PRU00541","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	7
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00541","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	Site: {"description":"Involved in NS3 ATPase and RTPase activities","evidences":[{"source":"UniProtKB","id":"P14335","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	1
Details	Modified residue: {"description":"N6-acetyllysine; by host","evidences":[{"source":"PubMed","id":"37478852","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---