Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

5RG3

PanDDA analysis group deposition SARS-CoV-2 main protease fragment screen -- Crystal Structure of SARS-CoV-2 main protease in complex with NCL-00025412

Functional Information from GO Data
ChainGOidnamespacecontents
A0008233molecular_functionpeptidase activity
A0019082biological_processviral protein processing
Functional Information from PDB Data
site_idAC1
Number of Residues7
Detailsbinding site for residue DMS A 401
ChainResidue
ALEU75
AARG76
APHE223
ATHR224
AASP263
AHOH535
AHOH599

site_idAC2
Number of Residues5
Detailsbinding site for residue DMS A 402
ChainResidue
ASER123
AGLN127
AARG298
AMET6
APHE8

site_idAC3
Number of Residues4
Detailsbinding site for residue DMS A 403
ChainResidue
AGLY15
AMET17
ALYS97
AHOH661

site_idAC4
Number of Residues5
Detailsbinding site for residue DMS A 404
ChainResidue
APHE140
ALEU141
ASER144
AHIS163
AGLU166

site_idAC5
Number of Residues11
Detailsbinding site for residue T9P A 405
ChainResidue
ATHR24
ATHR25
ATHR26
ALEU27
AASN119
AGLY143
ASER144
ACYS145
ADMS406
AHOH538
AHOH545

site_idAC6
Number of Residues5
Detailsbinding site for residue DMS A 406
ChainResidue
ATHR25
AHIS41
ACYS44
ASER46
AT9P405

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsACT_SITE: For 3CL-PRO activity => ECO:0000255|PROSITE-ProRule:PRU00772, ECO:0000305|PubMed:32198291
ChainResidueDetails
AHIS41

site_idSWS_FT_FI2
Number of Residues1
DetailsACT_SITE: Nucleophile; for 3CL-PRO activity => ECO:0000255|PROSITE-ProRule:PRU00772, ECO:0000269|PubMed:32198291
ChainResidueDetails
ACYS145

site_idSWS_FT_FI3
Number of Residues1
DetailsSITE: Cleavage; by 3CL-PRO => ECO:0000250|UniProtKB:P0C6V3
ChainResidueDetails
AGLN306

227111

PDB entries from 2024-11-06

PDB statisticsPDBj update infoContact PDBjnumon