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5R7Z

PanDDA analysis group deposition -- Crystal Structure of SARS-CoV-2 main protease in complex with Z1220452176

Functional Information from GO Data
ChainGOidnamespacecontents
A0008233molecular_functionpeptidase activity
A0019082biological_processviral protein processing
Functional Information from PDB Data
site_idAC1
Number of Residues8
Detailsbinding site for residue DMS A 401
ChainResidue
AGLN74
ALEU75
AARG76
APHE223
ATHR224
AASP263
AHOH516
AHOH564

site_idAC2
Number of Residues5
Detailsbinding site for residue DMS A 402
ChainResidue
APHE8
ASER123
AGLN127
AARG298
AMET6

site_idAC3
Number of Residues3
Detailsbinding site for residue DMS A 403
ChainResidue
AGLY15
AMET17
ALYS97

site_idAC4
Number of Residues13
Detailsbinding site for residue HWH A 404
ChainResidue
AHIS41
AMET49
AMET165
AGLU166
ALEU167
APRO168
AASP187
AARG188
AGLN189
ATHR190
AGLY251
APRO252
AHOH627

site_idAC5
Number of Residues6
Detailsbinding site for residue DMS A 405
ChainResidue
APHE140
ALEU141
ACYS145
AHIS163
AMET165
AGLU166

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsACT_SITE: For 3CL-PRO activity => ECO:0000255|PROSITE-ProRule:PRU00772, ECO:0000305|PubMed:32198291
ChainResidueDetails
AHIS41

site_idSWS_FT_FI2
Number of Residues1
DetailsACT_SITE: Nucleophile; for 3CL-PRO activity => ECO:0000255|PROSITE-ProRule:PRU00772, ECO:0000269|PubMed:32198291
ChainResidueDetails
ACYS145

site_idSWS_FT_FI3
Number of Residues1
DetailsSITE: Cleavage; by 3CL-PRO => ECO:0000250|UniProtKB:P0C6V3
ChainResidueDetails
AGLN306

226707

PDB entries from 2024-10-30

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