5R4R

PanDDA analysis group deposition -- Crystal Structure of HUMAN CLEAVAGE FACTOR IM in complex with EN08775-42

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003729	molecular_function	mRNA binding
A	0005849	cellular_component	mRNA cleavage factor complex
A	0031124	biological_process	mRNA 3'-end processing
B	0003729	molecular_function	mRNA binding
B	0005849	cellular_component	mRNA cleavage factor complex
B	0031124	biological_process	mRNA 3'-end processing

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	binding site for residue ZN A 301

Chain	Residue
A	MET76
A	TRP149
A	HIS171

---

site_id	AC2
Number of Residues	2
Details	binding site for residue ZN A 302

Chain	Residue
A	HIS89
B	GLU200

---

site_id	AC3
Number of Residues	8
Details	binding site for residue ACT A 303

Chain	Residue
A	PHE222
A	HOH422
A	HOH481
A	HOH530
A	GLU34
A	ASN147
A	HIS171
A	LYS173

---

site_id	AC4
Number of Residues	4
Details	binding site for residue ACT A 304

Chain	Residue
A	PHE199
A	TYR202
A	ASP203
A	ASN204

---

site_id	AC5
Number of Residues	13
Details	binding site for residue RWA A 305

Chain	Residue
A	LYS56
A	ARG66
A	LEU97
A	LEU106
A	GLY108
A	GLU110
A	GLU127
A	ILE128
A	TYR191
A	HOH405
A	HOH409
A	HOH412
A	HOH516

---

site_id	AC6
Number of Residues	5
Details	binding site for residue ZN B 301

Chain	Residue
A	HIS89
A	HOH462
B	GLU88
B	HIS93
B	HOH401

---

site_id	AC7
Number of Residues	6
Details	binding site for residue ZN B 302

Chain	Residue
A	GLU88
A	HIS93
A	HOH401
A	HOH407
A	HOH519
B	HIS164

---

site_id	AC8
Number of Residues	2
Details	binding site for residue ZN B 303

Chain	Residue
A	ALA195
B	HIS164

---

site_id	AC9
Number of Residues	1
Details	binding site for residue ZN B 304

Chain	Residue
B	TRP149

---

site_id	AD1
Number of Residues	5
Details	binding site for residue ACT B 305

Chain	Residue
A	HIS164
B	TYR160
B	PHE199
B	TYR202
B	HOH409

---

site_id	AD2
Number of Residues	12
Details	binding site for residue RWA B 306

Chain	Residue
B	LEU53
B	LYS56
B	ARG66
B	LEU97
B	LYS105
B	LEU106
B	GLY108
B	GLY109
B	GLU110
B	GLU127
B	ILE128
B	TYR191

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	250
Details	Domain: {"description":"Nudix hydrolase","evidences":[{"source":"PROSITE-ProRule","id":"PRU00794","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	158
Details	Region: {"description":"Necessary for interactions with PAPOLA and PABPN1","evidences":[{"source":"PubMed","id":"15169763","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	Region: {"description":"Interaction with RNA","evidences":[{"source":"PubMed","id":"20479262","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21295486","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3MDG","evidenceCode":"ECO:0000312"},{"source":"PDB","id":"3MDI","evidenceCode":"ECO:0000312"},{"source":"PDB","id":"3Q2T","evidenceCode":"ECO:0000312"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	42
Details	Motif: {"description":"Nudix box"}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	Site: {"description":"Interaction with RNA","evidences":[{"source":"PubMed","id":"20479262","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3MDG","evidenceCode":"ECO:0000312"},{"source":"PDB","id":"3MDI","evidenceCode":"ECO:0000312"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"15592455","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	2
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---