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5QSD

PanDDA analysis group deposition -- Crystal Structure of human Brachyury G177D variant in complex with Z54571979

Functional Information from GO Data
ChainGOidnamespacecontents
A0000978molecular_functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
A0003700molecular_functionDNA-binding transcription factor activity
A0005634cellular_componentnucleus
A0006355biological_processregulation of DNA-templated transcription
A0045893biological_processpositive regulation of DNA-templated transcription
Functional Information from PDB Data
site_idAC1
Number of Residues8
Detailsbinding site for residue O0S A 301
ChainResidue
ALEU91
AVAL123
AARG169
AGLN179
AARG180
AILE182
AHIS185
ACYS186

Functional Information from PROSITE/UniProt
site_idPS01264
Number of Residues19
DetailsTBOX_2 T-box domain signature 2. IHPDSpnfGahWMkapVsF
ChainResidueDetails
AILE125-PHE143

site_idPS01283
Number of Residues20
DetailsTBOX_1 T-box domain signature 1. LWlrFkeltNEMIVTknGRR
ChainResidueDetails
ALEU51-ARG70

227111

PDB entries from 2024-11-06

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