5QIV
Covalent fragment group deposition -- Crystal Structure of OUTB2 in complex with PCM-0102998
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004843 | molecular_function | cysteine-type deubiquitinase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0006508 | biological_process | proteolysis |
| A | 0008233 | molecular_function | peptidase activity |
| A | 0008234 | molecular_function | cysteine-type peptidase activity |
| A | 0016579 | biological_process | protein deubiquitination |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0035871 | biological_process | protein K11-linked deubiquitination |
| A | 0043130 | molecular_function | ubiquitin binding |
| A | 0070536 | biological_process | protein K63-linked deubiquitination |
| A | 0071108 | biological_process | protein K48-linked deubiquitination |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 2 |
| Details | binding site for residue EDO A 601 |
| Chain | Residue |
| A | ARG38 |
| A | GLN192 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | binding site for residue EDO A 602 |
| Chain | Residue |
| A | PHE6 |
| A | ASN7 |
| A | LEU8 |
| A | SER10 |
| A | LYS44 |
| A | THR45 |
| A | LYS46 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | binding site for residue EDO A 603 |
| Chain | Residue |
| A | GLN133 |
| A | GLU169 |
| A | HOH702 |
| A | HOH703 |
| A | HOH709 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | binding site for residue EDO A 604 |
| Chain | Residue |
| A | GLU76 |
| A | ARG77 |
| A | GLN80 |
| A | HOH708 |
| A | HOH758 |
| A | HOH868 |
| site_id | AC5 |
| Number of Residues | 7 |
| Details | binding site for residue EDO A 605 |
| Chain | Residue |
| A | GLU11 |
| A | LYS12 |
| A | ARG43 |
| A | LEU119 |
| A | GLU157 |
| A | HOH818 |
| A | HOH934 |
| site_id | AC6 |
| Number of Residues | 10 |
| Details | binding site for residue J5P A 606 |
| Chain | Residue |
| A | GLY47 |
| A | ASP48 |
| A | ARG49 |
| A | ASN50 |
| A | CYS51 |
| A | PHE52 |
| A | GLU174 |
| A | THR222 |
| A | SER223 |
| A | HIS224 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Active site: {"evidences":[{"source":"PubMed","id":"15258613","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Nucleophile","evidences":[{"source":"PubMed","id":"12704427","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"15258613","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | Site: {"description":"Required to orient and stabilize the active site H-224","evidences":[{"source":"PubMed","id":"15258613","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
