5QCK

FACTOR XIA IN COMPLEX WITH THE INHIBITOR 4-[[(2~{S},3~{R})-1-[(~{E})-3-[5-chloranyl-2-(1,2,3,4-tetrazol-1-yl)phenyl]prop-2-enoyl]-3-phenyl-pyrrolidin-2-yl]carbonylamino]benzoic acid

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004252	molecular_function	serine-type endopeptidase activity
A	0006508	biological_process	proteolysis

Functional Information from PDB Data

site_id	AC1
Number of Residues	20
Details	binding site for residue BUV A 301

Chain	Residue
A	ARG39
A	LYS192
A	GLY193
A	ASP194
A	SER195
A	THR213
A	TRP215
A	GLY216
A	GLY218
A	CYS219
A	GLY226
A	HIS57
A	VAL227
A	CYS58
A	TYR143
A	LEU147
A	ILE151
A	ASP189
A	ALA190
A	CYS191

---

site_id	AC2
Number of Residues	6
Details	binding site for residue SO4 A 302

Chain	Residue
A	LYS169
A	LYS169
A	ARG170
A	ARG170
A	ARG184
A	ARG184

---

site_id	AC3
Number of Residues	4
Details	binding site for residue EDO A 303

Chain	Residue
A	ASN49
A	THR111
A	VAL112
A	TYR114

---

site_id	AC4
Number of Residues	1
Details	binding site for residue EDO A 304

Chain	Residue
A	HIS178

---

site_id	AC5
Number of Residues	1
Details	binding site for residue EDO A 305

Chain	Residue
A	GLN38

---

Functional Information from PROSITE/UniProt

site_id	PS00134
Number of Residues	6
Details	TRYPSIN_HIS Serine proteases, trypsin family, histidine active site. LTAAHC

Chain	Residue	Details
A	LEU53-CYS58

---

site_id	PS00135
Number of Residues	12
Details	TRYPSIN_SER Serine proteases, trypsin family, serine active site. DAckGDSGGPLS

Chain	Residue	Details
A	ASP189-SER200

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	ACT_SITE: Charge relay system

Chain	Residue	Details
A	HIS57
A	ASP102
A	SER195

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	BINDING:

Chain	Residue	Details
A	LYS169

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	CARBOHYD: N-linked (GlcNAc...) (complex) asparagine => ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:25092234

Chain	Residue	Details
A	ASN72

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	CARBOHYD: N-linked (GlcNAc...) (complex) asparagine => ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:1998667, ECO:0000269|PubMed:25092234

Chain	Residue	Details
A	GLY113

---