5QAP

OXA-48 IN COMPLEX WITH COMPOUND 21a

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0008658	molecular_function	penicillin binding
A	0008800	molecular_function	beta-lactamase activity
A	0016787	molecular_function	hydrolase activity
A	0017001	biological_process	antibiotic catabolic process
A	0046677	biological_process	response to antibiotic
A	0046872	molecular_function	metal ion binding
A	0071555	biological_process	cell wall organization
B	0008658	molecular_function	penicillin binding
B	0008800	molecular_function	beta-lactamase activity
B	0016787	molecular_function	hydrolase activity
B	0017001	biological_process	antibiotic catabolic process
B	0046677	biological_process	response to antibiotic
B	0046872	molecular_function	metal ion binding
B	0071555	biological_process	cell wall organization
C	0008658	molecular_function	penicillin binding
C	0008800	molecular_function	beta-lactamase activity
C	0016787	molecular_function	hydrolase activity
C	0017001	biological_process	antibiotic catabolic process
C	0046677	biological_process	response to antibiotic
C	0046872	molecular_function	metal ion binding
C	0071555	biological_process	cell wall organization
D	0008658	molecular_function	penicillin binding
D	0008800	molecular_function	beta-lactamase activity
D	0016787	molecular_function	hydrolase activity
D	0017001	biological_process	antibiotic catabolic process
D	0046677	biological_process	response to antibiotic
D	0046872	molecular_function	metal ion binding
D	0071555	biological_process	cell wall organization

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	binding site for residue CL A 301

Chain	Residue
A	ARG206
C	ARG206
C	HOH652

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site_id	AC2
Number of Residues	6
Details	binding site for residue EDO A 302

Chain	Residue
A	SER40
A	ASP240
A	MET241
A	PRO242
A	HOH470
A	HOH472

---

site_id	AC3
Number of Residues	5
Details	binding site for residue EDO A 303

Chain	Residue
A	LEU81
A	SER184
A	ARG186
A	SER187
A	HOH432

---

site_id	AC4
Number of Residues	1
Details	binding site for residue CL B 301

Chain	Residue
B	ARG206

---

site_id	AC5
Number of Residues	7
Details	binding site for residue AV7 B 302

Chain	Residue
B	SER70
B	VAL120
B	LEU158
B	THR209
B	ARG214
B	ARG250
B	HOH411

---

site_id	AC6
Number of Residues	7
Details	binding site for residue EDO B 303

Chain	Residue
B	LYS39
B	SER40
B	MET239
B	ASP240
B	MET241
B	PRO242
B	HOH416

---

site_id	AC7
Number of Residues	3
Details	binding site for residue EDO B 304

Chain	Residue
B	ASN110
B	HOH412
B	HOH484

---

site_id	AC8
Number of Residues	6
Details	binding site for residue EDO B 305

Chain	Residue
B	LEU81
B	SER184
B	ARG186
B	SER187
B	HOH418
B	HOH480

---

site_id	AC9
Number of Residues	4
Details	binding site for residue EDO B 306

Chain	Residue
B	LYS94
B	TRP95
B	ASP96
B	HOH435

---

site_id	AD1
Number of Residues	15
Details	binding site for residue AV7 C 301

Chain	Residue
C	SER70
C	ILE102
C	TYR117
C	VAL120
C	THR209
C	THR213
C	ARG214
C	ARG250
C	HOH401
C	HOH408
C	HOH453
C	HOH497
C	HOH583
C	HOH592
C	HOH685

---

site_id	AD2
Number of Residues	5
Details	binding site for residue EDO C 302

Chain	Residue
C	LEU81
C	SER184
C	ARG186
C	SER187
C	HOH440

---

site_id	AD3
Number of Residues	8
Details	binding site for residue AV7 D 301

Chain	Residue
D	SER70
D	VAL120
D	LEU158
D	THR209
D	ARG214
D	ARG250
D	HOH415
D	HOH457

---

site_id	AD4
Number of Residues	6
Details	binding site for residue EDO D 302

Chain	Residue
D	LEU81
D	SER184
D	ARG186
D	SER187
D	HOH502
D	HOH551

---

site_id	AD5
Number of Residues	6
Details	binding site for residue EDO D 303

Chain	Residue
D	TYR177
D	GLU227
D	VAL232
D	HOH458
D	HOH467
D	HOH508

---

site_id	AD6
Number of Residues	4
Details	binding site for residue EDO D 304

Chain	Residue
D	LYS94
D	TRP95
D	ASP96
D	HOH527

---

Functional Information from PROSITE/UniProt

site_id	PS00337
Number of Residues	11
Details	BETA_LACTAMASE_D Beta-lactamase class-D active site. PaSTFKIPnSL

Chain	Residue	Details
A	PRO68-LEU78

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