5QAH

OXA-48 IN COMPLEX WITH COMPOUND 9b

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005886	cellular_component	plasma membrane
A	0008658	molecular_function	penicillin binding
A	0008800	molecular_function	beta-lactamase activity
A	0016787	molecular_function	hydrolase activity
A	0017001	biological_process	antibiotic catabolic process
A	0046677	biological_process	response to antibiotic
A	0071555	biological_process	cell wall organization
B	0005886	cellular_component	plasma membrane
B	0008658	molecular_function	penicillin binding
B	0008800	molecular_function	beta-lactamase activity
B	0016787	molecular_function	hydrolase activity
B	0017001	biological_process	antibiotic catabolic process
B	0046677	biological_process	response to antibiotic
B	0071555	biological_process	cell wall organization
C	0005886	cellular_component	plasma membrane
C	0008658	molecular_function	penicillin binding
C	0008800	molecular_function	beta-lactamase activity
C	0016787	molecular_function	hydrolase activity
C	0017001	biological_process	antibiotic catabolic process
C	0046677	biological_process	response to antibiotic
C	0071555	biological_process	cell wall organization
D	0005886	cellular_component	plasma membrane
D	0008658	molecular_function	penicillin binding
D	0008800	molecular_function	beta-lactamase activity
D	0016787	molecular_function	hydrolase activity
D	0017001	biological_process	antibiotic catabolic process
D	0046677	biological_process	response to antibiotic
D	0071555	biological_process	cell wall organization

Functional Information from PDB Data

site_id	AC1
Number of Residues	8
Details	binding site for residue EFX A 301

Chain	Residue
A	SER70
A	SER118
A	THR209
A	GLY210
A	SER244
A	LEU247
A	ARG250
A	HOH421

---

site_id	AC2
Number of Residues	4
Details	binding site for residue CL A 302

Chain	Residue
A	HOH618
C	ARG206
C	HOH614
A	ARG206

---

site_id	AC3
Number of Residues	6
Details	binding site for residue EDO A 303

Chain	Residue
A	LYS94
A	TRP95
A	ASP96
A	PRO121
A	HOH437
A	HOH503

---

site_id	AC4
Number of Residues	8
Details	binding site for residue EFX B 301

Chain	Residue
B	SER70
B	SER118
B	THR209
B	GLY210
B	TYR211
B	SER244
B	LEU247
B	ARG250

---

site_id	AC5
Number of Residues	1
Details	binding site for residue CL B 302

Chain	Residue
B	ARG206

---

site_id	AC6
Number of Residues	6
Details	binding site for residue EDO B 303

Chain	Residue
B	ALA65
B	PHE66
B	PRO217
B	HOH418
B	HOH464
B	HOH546

---

site_id	AC7
Number of Residues	7
Details	binding site for residue EFX C 301

Chain	Residue
C	SER70
C	SER118
C	THR209
C	GLY210
C	TYR211
C	SER244
C	ARG250

---

site_id	AC8
Number of Residues	5
Details	binding site for residue EDO C 302

Chain	Residue
A	ASN110
C	ASP229
C	ASP230
C	HOH507
C	HOH540

---

site_id	AC9
Number of Residues	4
Details	binding site for residue EDO C 303

Chain	Residue
C	THR167
C	ILE170
C	SER171
C	ARG174

---

site_id	AD1
Number of Residues	9
Details	binding site for residue EFX D 301

Chain	Residue
D	SER70
D	SER118
D	THR209
D	GLY210
D	TYR211
D	SER244
D	LEU247
D	ARG250
D	HOH402

---

site_id	AD2
Number of Residues	3
Details	binding site for residue EDO D 302

Chain	Residue
D	TRP47
D	SER171
D	ARG174

---

Functional Information from PROSITE/UniProt

site_id	PS00337
Number of Residues	11
Details	BETA_LACTAMASE_D Beta-lactamase class-D active site. PaSTFKIPnSL

Chain	Residue	Details
A	PRO68-LEU78

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	Active site: {"description":"Acyl-ester intermediate","evidences":[{"source":"PIRSR","id":"PIRSR602137-50","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"25406838","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26731698","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31358584","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32150407","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4WMC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5FAQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5FAS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6P97","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6P98","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6P99","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6P9C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6V1O","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"Q8RLA6","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P13661","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	Modified residue: {"description":"N6-carboxylysine","evidences":[{"source":"PIRSR","id":"PIRSR602137-50","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"19477418","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25406838","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3HBR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4WMC","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---