Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

5QAD

OXA-48 IN COMPLEX WITH COMPOUND 8a

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005886	cellular_component	plasma membrane
A	0008658	molecular_function	penicillin binding
A	0008800	molecular_function	beta-lactamase activity
A	0016787	molecular_function	hydrolase activity
A	0017001	biological_process	antibiotic catabolic process
A	0046677	biological_process	response to antibiotic
A	0071555	biological_process	cell wall organization
B	0005886	cellular_component	plasma membrane
B	0008658	molecular_function	penicillin binding
B	0008800	molecular_function	beta-lactamase activity
B	0016787	molecular_function	hydrolase activity
B	0017001	biological_process	antibiotic catabolic process
B	0046677	biological_process	response to antibiotic
B	0071555	biological_process	cell wall organization
C	0005886	cellular_component	plasma membrane
C	0008658	molecular_function	penicillin binding
C	0008800	molecular_function	beta-lactamase activity
C	0016787	molecular_function	hydrolase activity
C	0017001	biological_process	antibiotic catabolic process
C	0046677	biological_process	response to antibiotic
C	0071555	biological_process	cell wall organization
D	0005886	cellular_component	plasma membrane
D	0008658	molecular_function	penicillin binding
D	0008800	molecular_function	beta-lactamase activity
D	0016787	molecular_function	hydrolase activity
D	0017001	biological_process	antibiotic catabolic process
D	0046677	biological_process	response to antibiotic
D	0071555	biological_process	cell wall organization

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	binding site for residue WVV A 301

Chain	Residue
A	TYR117
A	ARG250
A	EDO307
A	HOH402
A	HOH405

site_id	AC2
Number of Residues	6
Details	binding site for residue EDO A 302

Chain	Residue
A	HOH432
A	HOH485
A	SER40
A	ASP240
A	MET241
A	PRO242

site_id	AC3
Number of Residues	2
Details	binding site for residue EDO A 303

Chain	Residue
A	HIS38
A	GLU256

site_id	AC4
Number of Residues	5
Details	binding site for residue EDO A 304

Chain	Residue
A	LEU81
A	SER184
A	ARG186
A	SER187
A	HOH501

site_id	AC5
Number of Residues	4
Details	binding site for residue EDO A 305

Chain	Residue
A	VAL92
A	ASN110
C	ASP229
C	ASP230

site_id	AC6
Number of Residues	6
Details	binding site for residue EDO A 306

Chain	Residue
A	LYS94
A	TRP95
A	ASP96
A	VAL122
A	HOH466
A	HOH586

site_id	AC7
Number of Residues	4
Details	binding site for residue EDO A 307

Chain	Residue
A	ASP101
A	WVV301
A	HOH420
A	HOH438

site_id	AC8
Number of Residues	2
Details	binding site for residue EDO A 308

Chain	Residue
A	ARG100
C	HOH416

site_id	AC9
Number of Residues	4
Details	binding site for residue EDO A 309

Chain	Residue
A	GLU198
A	ASN200
C	GLU198
C	ALA199

site_id	AD1
Number of Residues	5
Details	binding site for residue WVV B 301

Chain	Residue
B	TYR117
B	ARG250
B	HOH403
B	HOH407
B	HOH580

site_id	AD2
Number of Residues	1
Details	binding site for residue CL B 302

Chain	Residue
B	ARG206

site_id	AD3
Number of Residues	2
Details	binding site for residue EDO B 303

Chain	Residue
B	HOH517
B	HOH540

site_id	AD4
Number of Residues	6
Details	binding site for residue EDO B 304

Chain	Residue
B	SER40
B	ASP240
B	MET241
B	PRO242
B	HOH420
B	HOH450

site_id	AD5
Number of Residues	5
Details	binding site for residue EDO B 305

Chain	Residue
B	LYS94
B	TRP95
B	ASP96
B	HOH453
B	HOH544

site_id	AD6
Number of Residues	5
Details	binding site for residue EDO B 306

Chain	Residue
B	SER184
B	ARG186
B	SER187
B	HOH462
B	HOH474

site_id	AD7
Number of Residues	5
Details	binding site for residue EDO B 307

Chain	Residue
A	ARG214
B	ARG100
B	HOH425
B	HOH564
B	HOH579

site_id	AD8
Number of Residues	5
Details	binding site for residue WVV C 301

Chain	Residue
C	TYR117
C	SER118
C	ARG250
C	HOH401
C	HOH436

site_id	AD9
Number of Residues	3
Details	binding site for residue CL C 302

Chain	Residue
A	ARG206
A	HOH665
C	ARG206

site_id	AE1
Number of Residues	4
Details	binding site for residue EDO C 303

Chain	Residue
A	ASP229
A	ASP230
C	ASN110
C	HOH450

site_id	AE2
Number of Residues	3
Details	binding site for residue EDO C 304

Chain	Residue
C	ARG100
C	ASP101
C	HOH512

site_id	AE3
Number of Residues	7
Details	binding site for residue EDO C 305

Chain	Residue
A	HIS90
C	TYR177
C	GLU227
C	VAL232
C	HOH426
C	HOH452
C	HOH520

site_id	AE4
Number of Residues	4
Details	binding site for residue EDO C 306

Chain	Residue
C	TRP25
C	THR167
C	SER171
C	ARG174

site_id	AE5
Number of Residues	5
Details	binding site for residue EDO C 307

Chain	Residue
C	LEU81
C	SER184
C	ARG186
C	SER187
C	HOH439

site_id	AE6
Number of Residues	5
Details	binding site for residue WVV D 301

Chain	Residue
D	ARG250
D	HOH411
D	HOH415
D	HOH440
D	THR209

site_id	AE7
Number of Residues	2
Details	binding site for residue EDO D 302

Chain	Residue
D	ASN110
D	HOH527

site_id	AE8
Number of Residues	3
Details	binding site for residue EDO D 303

Chain	Residue
D	LYS116
D	HOH418
D	HOH419

site_id	AE9
Number of Residues	6
Details	binding site for residue EDO D 304

Chain	Residue
D	TYR177
D	GLU227
D	VAL232
D	HOH423
D	HOH470
D	HOH504

site_id	AF1
Number of Residues	5
Details	binding site for residue EDO D 305

Chain	Residue
D	LEU81
D	SER184
D	ARG186
D	SER187
D	HOH435

site_id	AF2
Number of Residues	2
Details	binding site for residue EDO D 306

Chain	Residue
D	ARG100
D	ASP101

site_id	AF3
Number of Residues	4
Details	binding site for residue EDO D 307

Chain	Residue
D	THR167
D	ILE170
D	SER171
D	ARG174

Functional Information from PROSITE/UniProt

site_id	PS00337
Number of Residues	11
Details	BETA_LACTAMASE_D Beta-lactamase class-D active site. PaSTFKIPnSL

Chain	Residue	Details
A	PRO68-LEU78

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	Active site: {"description":"Acyl-ester intermediate","evidences":[{"source":"PIRSR","id":"PIRSR602137-50","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"25406838","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26731698","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31358584","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32150407","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4WMC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5FAQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5FAS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6P97","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6P98","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6P99","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6P9C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6V1O","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"Q8RLA6","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P13661","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	4
Details	Modified residue: {"description":"N6-carboxylysine","evidences":[{"source":"PIRSR","id":"PIRSR602137-50","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"19477418","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25406838","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3HBR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4WMC","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)