5QA8
OXA-48 IN COMPLEX WITH COMPOUND 4c
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0008658 | molecular_function | penicillin binding |
| A | 0008800 | molecular_function | beta-lactamase activity |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0017001 | biological_process | antibiotic catabolic process |
| A | 0046677 | biological_process | response to antibiotic |
| A | 0071555 | biological_process | cell wall organization |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0008658 | molecular_function | penicillin binding |
| B | 0008800 | molecular_function | beta-lactamase activity |
| B | 0016787 | molecular_function | hydrolase activity |
| B | 0017001 | biological_process | antibiotic catabolic process |
| B | 0046677 | biological_process | response to antibiotic |
| B | 0071555 | biological_process | cell wall organization |
| C | 0005886 | cellular_component | plasma membrane |
| C | 0008658 | molecular_function | penicillin binding |
| C | 0008800 | molecular_function | beta-lactamase activity |
| C | 0016787 | molecular_function | hydrolase activity |
| C | 0017001 | biological_process | antibiotic catabolic process |
| C | 0046677 | biological_process | response to antibiotic |
| C | 0071555 | biological_process | cell wall organization |
| D | 0005886 | cellular_component | plasma membrane |
| D | 0008658 | molecular_function | penicillin binding |
| D | 0008800 | molecular_function | beta-lactamase activity |
| D | 0016787 | molecular_function | hydrolase activity |
| D | 0017001 | biological_process | antibiotic catabolic process |
| D | 0046677 | biological_process | response to antibiotic |
| D | 0071555 | biological_process | cell wall organization |
Functional Information from PROSITE/UniProt
| site_id | PS00337 |
| Number of Residues | 11 |
| Details | BETA_LACTAMASE_D Beta-lactamase class-D active site. PaSTFKIPnSL |
| Chain | Residue | Details |
| A | PRO68-LEU78 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | ACT_SITE: Acyl-ester intermediate => ECO:0000255|PIRSR:PIRSR602137-50, ECO:0000269|PubMed:25406838, ECO:0000269|PubMed:26731698, ECO:0000269|PubMed:31358584, ECO:0000269|PubMed:32150407, ECO:0007744|PDB:4WMC, ECO:0007744|PDB:5FAQ, ECO:0007744|PDB:5FAS, ECO:0007744|PDB:6P97, ECO:0007744|PDB:6P98, ECO:0007744|PDB:6P99, ECO:0007744|PDB:6P9C, ECO:0007744|PDB:6V1O |
| Chain | Residue | Details |
| A | SER70 | |
| B | SER70 | |
| C | SER70 | |
| D | SER70 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 12 |
| Details | BINDING: BINDING => ECO:0000250|UniProtKB:Q8RLA6 |
| Chain | Residue | Details |
| A | SER70 | |
| D | SER70 | |
| D | SER118 | |
| D | ARG250 | |
| A | SER118 | |
| A | ARG250 | |
| B | SER70 | |
| B | SER118 | |
| B | ARG250 | |
| C | SER70 | |
| C | SER118 | |
| C | ARG250 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000250|UniProtKB:P13661 |
| Chain | Residue | Details |
| A | KCX73 | |
| B | KCX73 | |
| C | KCX73 | |
| D | KCX73 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | MOD_RES: N6-carboxylysine => ECO:0000255|PIRSR:PIRSR602137-50, ECO:0000269|PubMed:19477418, ECO:0000269|PubMed:25406838, ECO:0007744|PDB:3HBR, ECO:0007744|PDB:4WMC |
| Chain | Residue | Details |
| A | KCX73 | |
| B | KCX73 | |
| C | KCX73 | |
| D | KCX73 |
