5QA5

OXA-48 IN COMPLEX WITH COMPOUND 3b

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0008658	molecular_function	penicillin binding
A	0008800	molecular_function	beta-lactamase activity
A	0016787	molecular_function	hydrolase activity
A	0017001	biological_process	antibiotic catabolic process
A	0046677	biological_process	response to antibiotic
A	0046872	molecular_function	metal ion binding
A	0071555	biological_process	cell wall organization
B	0008658	molecular_function	penicillin binding
B	0008800	molecular_function	beta-lactamase activity
B	0016787	molecular_function	hydrolase activity
B	0017001	biological_process	antibiotic catabolic process
B	0046677	biological_process	response to antibiotic
B	0046872	molecular_function	metal ion binding
B	0071555	biological_process	cell wall organization
C	0008658	molecular_function	penicillin binding
C	0008800	molecular_function	beta-lactamase activity
C	0016787	molecular_function	hydrolase activity
C	0017001	biological_process	antibiotic catabolic process
C	0046677	biological_process	response to antibiotic
C	0046872	molecular_function	metal ion binding
C	0071555	biological_process	cell wall organization
D	0008658	molecular_function	penicillin binding
D	0008800	molecular_function	beta-lactamase activity
D	0016787	molecular_function	hydrolase activity
D	0017001	biological_process	antibiotic catabolic process
D	0046677	biological_process	response to antibiotic
D	0046872	molecular_function	metal ion binding
D	0071555	biological_process	cell wall organization

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	binding site for residue L5D A 301

Chain	Residue
A	ILE102
A	TYR117
A	THR209
A	SER244
A	ARG250
A	HOH564

---

site_id	AC2
Number of Residues	6
Details	binding site for residue EDO A 302

Chain	Residue
A	PRO242
A	HOH426
A	HOH432
A	SER40
A	ASP240
A	MET241

---

site_id	AC3
Number of Residues	5
Details	binding site for residue EDO A 303

Chain	Residue
A	LYS94
A	TRP95
A	ASP96
A	HOH455
A	HOH494

---

site_id	AC4
Number of Residues	7
Details	binding site for residue L5D B 301

Chain	Residue
B	TYR117
B	SER244
B	ARG250
B	HOH404
B	HOH412
B	HOH530
B	HOH569

---

site_id	AC5
Number of Residues	6
Details	binding site for residue EDO B 302

Chain	Residue
B	LYS94
B	TRP95
B	ASP96
B	HOH415
B	HOH424
B	HOH545

---

site_id	AC6
Number of Residues	7
Details	binding site for residue EDO B 303

Chain	Residue
B	LYS39
B	SER40
B	MET239
B	ASP240
B	MET241
B	PRO242
B	HOH469

---

site_id	AC7
Number of Residues	5
Details	binding site for residue EDO B 304

Chain	Residue
B	ALA65
B	PHE66
B	PRO217
B	HOH570
C	HOH494

---

site_id	AC8
Number of Residues	9
Details	binding site for residue L5D C 301

Chain	Residue
C	ILE102
C	TYR117
C	SER118
C	THR209
C	TYR211
C	SER244
C	ARG250
C	HOH435
C	HOH543

---

site_id	AC9
Number of Residues	4
Details	binding site for residue CL C 302

Chain	Residue
A	ARG206
A	HOH617
C	ARG206
C	HOH594

---

site_id	AD1
Number of Residues	2
Details	binding site for residue EDO C 303

Chain	Residue
C	SER171
C	ARG174

---

site_id	AD2
Number of Residues	8
Details	binding site for residue L5D D 301

Chain	Residue
D	TYR117
D	THR209
D	TYR211
D	SER244
D	ARG250
D	HOH440
D	HOH534
D	HOH536

---

site_id	AD3
Number of Residues	5
Details	binding site for residue CL D 302

Chain	Residue
D	LEU228
D	ASN231
D	VAL232
D	HOH418
D	HOH629

---

site_id	AD4
Number of Residues	1
Details	binding site for residue CL D 303

Chain	Residue
D	ARG206

---

site_id	AD5
Number of Residues	4
Details	binding site for residue EDO D 304

Chain	Residue
D	TRP25
D	LEU59
D	ASN63
D	THR167

---

site_id	AD6
Number of Residues	2
Details	binding site for residue EDO D 305

Chain	Residue
D	ARG100
D	ASP101

---

site_id	AD7
Number of Residues	5
Details	binding site for residue EDO D 306

Chain	Residue
D	LEU81
D	SER184
D	ARG186
D	SER187
D	HOH466

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Functional Information from PROSITE/UniProt

site_id	PS00337
Number of Residues	11
Details	BETA_LACTAMASE_D Beta-lactamase class-D active site. PaSTFKIPnSL

Chain	Residue	Details
A	PRO68-LEU78

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