5Q1H

Ligand binding to FARNESOID-X-RECEPTOR

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003677	molecular_function	DNA binding
A	0004879	molecular_function	nuclear receptor activity
A	0006355	biological_process	regulation of DNA-templated transcription
A	0032052	molecular_function	bile acid binding
A	0038183	biological_process	bile acid signaling pathway
C	0003677	molecular_function	DNA binding
C	0004879	molecular_function	nuclear receptor activity
C	0006355	biological_process	regulation of DNA-templated transcription
C	0032052	molecular_function	bile acid binding
C	0038183	biological_process	bile acid signaling pathway
E	0003677	molecular_function	DNA binding
E	0004879	molecular_function	nuclear receptor activity
E	0006355	biological_process	regulation of DNA-templated transcription
E	0032052	molecular_function	bile acid binding
E	0038183	biological_process	bile acid signaling pathway
G	0003677	molecular_function	DNA binding
G	0004879	molecular_function	nuclear receptor activity
G	0006355	biological_process	regulation of DNA-templated transcription
G	0032052	molecular_function	bile acid binding
G	0038183	biological_process	bile acid signaling pathway

Functional Information from PDB Data

site_id	AC1
Number of Residues	15
Details	binding site for residue 9NP A 500

Chain	Residue
A	ILE277
A	ILE361
A	TYR373
A	HIS451
A	MET454
A	LEU455
A	TRP458
A	ASN287
A	LEU291
A	MET294
A	HIS298
A	PHE333
A	SER336
A	ILE339
A	ILE356

---

site_id	AC2
Number of Residues	14
Details	binding site for residue 9NP C 500

Chain	Residue
C	ILE277
C	ILE290
C	LEU291
C	MET294
C	HIS298
C	MET332
C	SER336
C	ILE356
C	ILE361
C	TYR373
C	HIS451
C	MET454
C	LEU455
C	TRP458

---

site_id	AC3
Number of Residues	14
Details	binding site for residue 9NP E 500

Chain	Residue
E	ILE277
E	LEU291
E	MET294
E	HIS298
E	PHE333
E	SER336
E	ILE356
E	SER359
E	ILE361
E	TYR373
E	HIS451
E	MET454
E	LEU455
E	TRP458

---

site_id	AC4
Number of Residues	12
Details	binding site for residue 9NP G 500

Chain	Residue
G	LEU291
G	MET294
G	HIS298
G	MET332
G	PHE333
G	SER336
G	ILE356
G	TYR373
G	HIS451
G	MET454
G	LEU455
G	TRP458

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	16
Details	BINDING: BINDING => ECO:0007744|PDB:6HL1

Chain	Residue	Details
A	ARG335
E	TYR365
E	TYR373
E	HIS451
G	ARG335
G	TYR365
G	TYR373
G	HIS451
A	TYR365
A	TYR373
A	HIS451
C	ARG335
C	TYR365
C	TYR373
C	HIS451
E	ARG335

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	MOD_RES: Phosphothreonine; by PKC/PRKCZ => ECO:0000305|PubMed:18668687

Chain	Residue	Details
A	THR446
C	THR446
E	THR446
G	THR446

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site_id	SWS_FT_FI3
Number of Residues	8
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1) => ECO:0000305|PubMed:23546875

Chain	Residue	Details
A	LYS279
C	LYS279
E	LYS279
G	LYS279

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