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5Q08

Human liver fructose-1,6-bisphosphatase 1 (fructose 1,6-bisphosphate 1-phosphatase, E.C.3.1.3.11) complexed with the allosteric inhibitor 1-(1-benzothiophen-3-ylsulfonyl)-3-(5-bromo-1,3-thiazol-2-yl)urea

Functional Information from GO Data
ChainGOidnamespacecontents
A0000122biological_processnegative regulation of transcription by RNA polymerase II
A0003824molecular_functioncatalytic activity
A0005515molecular_functionprotein binding
A0005615cellular_componentextracellular space
A0005634cellular_componentnucleus
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0005975biological_processcarbohydrate metabolic process
A0006000biological_processfructose metabolic process
A0006002biological_processfructose 6-phosphate metabolic process
A0006094biological_processgluconeogenesis
A0006111biological_processregulation of gluconeogenesis
A0016208molecular_functionAMP binding
A0016787molecular_functionhydrolase activity
A0016791molecular_functionphosphatase activity
A0030308biological_processnegative regulation of cell growth
A0030388biological_processfructose 1,6-bisphosphate metabolic process
A0031667biological_processresponse to nutrient levels
A0032869biological_processcellular response to insulin stimulus
A0042132molecular_functionfructose 1,6-bisphosphate 1-phosphatase activity
A0042578molecular_functionphosphoric ester hydrolase activity
A0042802molecular_functionidentical protein binding
A0045820biological_processnegative regulation of glycolytic process
A0046580biological_processnegative regulation of Ras protein signal transduction
A0046872molecular_functionmetal ion binding
A0048029molecular_functionmonosaccharide binding
A0061629molecular_functionRNA polymerase II-specific DNA-binding transcription factor binding
A0070062cellular_componentextracellular exosome
A0071286biological_processcellular response to magnesium ion
A0071320biological_processcellular response to cAMP
A0071466biological_processcellular response to xenobiotic stimulus
A0071475biological_processcellular hyperosmotic salinity response
A0071477biological_processcellular hypotonic salinity response
A0097403biological_processcellular response to raffinose
A1904628biological_processcellular response to phorbol 13-acetate 12-myristate
B0000122biological_processnegative regulation of transcription by RNA polymerase II
B0003824molecular_functioncatalytic activity
B0005515molecular_functionprotein binding
B0005615cellular_componentextracellular space
B0005634cellular_componentnucleus
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0005975biological_processcarbohydrate metabolic process
B0006000biological_processfructose metabolic process
B0006002biological_processfructose 6-phosphate metabolic process
B0006094biological_processgluconeogenesis
B0006111biological_processregulation of gluconeogenesis
B0016208molecular_functionAMP binding
B0016787molecular_functionhydrolase activity
B0016791molecular_functionphosphatase activity
B0030308biological_processnegative regulation of cell growth
B0030388biological_processfructose 1,6-bisphosphate metabolic process
B0031667biological_processresponse to nutrient levels
B0032869biological_processcellular response to insulin stimulus
B0042132molecular_functionfructose 1,6-bisphosphate 1-phosphatase activity
B0042578molecular_functionphosphoric ester hydrolase activity
B0042802molecular_functionidentical protein binding
B0045820biological_processnegative regulation of glycolytic process
B0046580biological_processnegative regulation of Ras protein signal transduction
B0046872molecular_functionmetal ion binding
B0048029molecular_functionmonosaccharide binding
B0061629molecular_functionRNA polymerase II-specific DNA-binding transcription factor binding
B0070062cellular_componentextracellular exosome
B0071286biological_processcellular response to magnesium ion
B0071320biological_processcellular response to cAMP
B0071466biological_processcellular response to xenobiotic stimulus
B0071475biological_processcellular hyperosmotic salinity response
B0071477biological_processcellular hypotonic salinity response
B0097403biological_processcellular response to raffinose
B1904628biological_processcellular response to phorbol 13-acetate 12-myristate
C0000122biological_processnegative regulation of transcription by RNA polymerase II
C0003824molecular_functioncatalytic activity
C0005515molecular_functionprotein binding
C0005615cellular_componentextracellular space
C0005634cellular_componentnucleus
C0005737cellular_componentcytoplasm
C0005829cellular_componentcytosol
C0005975biological_processcarbohydrate metabolic process
C0006000biological_processfructose metabolic process
C0006002biological_processfructose 6-phosphate metabolic process
C0006094biological_processgluconeogenesis
C0006111biological_processregulation of gluconeogenesis
C0016208molecular_functionAMP binding
C0016787molecular_functionhydrolase activity
C0016791molecular_functionphosphatase activity
C0030308biological_processnegative regulation of cell growth
C0030388biological_processfructose 1,6-bisphosphate metabolic process
C0031667biological_processresponse to nutrient levels
C0032869biological_processcellular response to insulin stimulus
C0042132molecular_functionfructose 1,6-bisphosphate 1-phosphatase activity
C0042578molecular_functionphosphoric ester hydrolase activity
C0042802molecular_functionidentical protein binding
C0045820biological_processnegative regulation of glycolytic process
C0046580biological_processnegative regulation of Ras protein signal transduction
C0046872molecular_functionmetal ion binding
C0048029molecular_functionmonosaccharide binding
C0061629molecular_functionRNA polymerase II-specific DNA-binding transcription factor binding
C0070062cellular_componentextracellular exosome
C0071286biological_processcellular response to magnesium ion
C0071320biological_processcellular response to cAMP
C0071466biological_processcellular response to xenobiotic stimulus
C0071475biological_processcellular hyperosmotic salinity response
C0071477biological_processcellular hypotonic salinity response
C0097403biological_processcellular response to raffinose
C1904628biological_processcellular response to phorbol 13-acetate 12-myristate
D0000122biological_processnegative regulation of transcription by RNA polymerase II
D0003824molecular_functioncatalytic activity
D0005515molecular_functionprotein binding
D0005615cellular_componentextracellular space
D0005634cellular_componentnucleus
D0005737cellular_componentcytoplasm
D0005829cellular_componentcytosol
D0005975biological_processcarbohydrate metabolic process
D0006000biological_processfructose metabolic process
D0006002biological_processfructose 6-phosphate metabolic process
D0006094biological_processgluconeogenesis
D0006111biological_processregulation of gluconeogenesis
D0016208molecular_functionAMP binding
D0016787molecular_functionhydrolase activity
D0016791molecular_functionphosphatase activity
D0030308biological_processnegative regulation of cell growth
D0030388biological_processfructose 1,6-bisphosphate metabolic process
D0031667biological_processresponse to nutrient levels
D0032869biological_processcellular response to insulin stimulus
D0042132molecular_functionfructose 1,6-bisphosphate 1-phosphatase activity
D0042578molecular_functionphosphoric ester hydrolase activity
D0042802molecular_functionidentical protein binding
D0045820biological_processnegative regulation of glycolytic process
D0046580biological_processnegative regulation of Ras protein signal transduction
D0046872molecular_functionmetal ion binding
D0048029molecular_functionmonosaccharide binding
D0061629molecular_functionRNA polymerase II-specific DNA-binding transcription factor binding
D0070062cellular_componentextracellular exosome
D0071286biological_processcellular response to magnesium ion
D0071320biological_processcellular response to cAMP
D0071466biological_processcellular response to xenobiotic stimulus
D0071475biological_processcellular hyperosmotic salinity response
D0071477biological_processcellular hypotonic salinity response
D0097403biological_processcellular response to raffinose
D1904628biological_processcellular response to phorbol 13-acetate 12-myristate
E0000122biological_processnegative regulation of transcription by RNA polymerase II
E0003824molecular_functioncatalytic activity
E0005515molecular_functionprotein binding
E0005615cellular_componentextracellular space
E0005634cellular_componentnucleus
E0005737cellular_componentcytoplasm
E0005829cellular_componentcytosol
E0005975biological_processcarbohydrate metabolic process
E0006000biological_processfructose metabolic process
E0006002biological_processfructose 6-phosphate metabolic process
E0006094biological_processgluconeogenesis
E0006111biological_processregulation of gluconeogenesis
E0016208molecular_functionAMP binding
E0016787molecular_functionhydrolase activity
E0016791molecular_functionphosphatase activity
E0030308biological_processnegative regulation of cell growth
E0030388biological_processfructose 1,6-bisphosphate metabolic process
E0031667biological_processresponse to nutrient levels
E0032869biological_processcellular response to insulin stimulus
E0042132molecular_functionfructose 1,6-bisphosphate 1-phosphatase activity
E0042578molecular_functionphosphoric ester hydrolase activity
E0042802molecular_functionidentical protein binding
E0045820biological_processnegative regulation of glycolytic process
E0046580biological_processnegative regulation of Ras protein signal transduction
E0046872molecular_functionmetal ion binding
E0048029molecular_functionmonosaccharide binding
E0061629molecular_functionRNA polymerase II-specific DNA-binding transcription factor binding
E0070062cellular_componentextracellular exosome
E0071286biological_processcellular response to magnesium ion
E0071320biological_processcellular response to cAMP
E0071466biological_processcellular response to xenobiotic stimulus
E0071475biological_processcellular hyperosmotic salinity response
E0071477biological_processcellular hypotonic salinity response
E0097403biological_processcellular response to raffinose
E1904628biological_processcellular response to phorbol 13-acetate 12-myristate
F0000122biological_processnegative regulation of transcription by RNA polymerase II
F0003824molecular_functioncatalytic activity
F0005515molecular_functionprotein binding
F0005615cellular_componentextracellular space
F0005634cellular_componentnucleus
F0005737cellular_componentcytoplasm
F0005829cellular_componentcytosol
F0005975biological_processcarbohydrate metabolic process
F0006000biological_processfructose metabolic process
F0006002biological_processfructose 6-phosphate metabolic process
F0006094biological_processgluconeogenesis
F0006111biological_processregulation of gluconeogenesis
F0016208molecular_functionAMP binding
F0016787molecular_functionhydrolase activity
F0016791molecular_functionphosphatase activity
F0030308biological_processnegative regulation of cell growth
F0030388biological_processfructose 1,6-bisphosphate metabolic process
F0031667biological_processresponse to nutrient levels
F0032869biological_processcellular response to insulin stimulus
F0042132molecular_functionfructose 1,6-bisphosphate 1-phosphatase activity
F0042578molecular_functionphosphoric ester hydrolase activity
F0042802molecular_functionidentical protein binding
F0045820biological_processnegative regulation of glycolytic process
F0046580biological_processnegative regulation of Ras protein signal transduction
F0046872molecular_functionmetal ion binding
F0048029molecular_functionmonosaccharide binding
F0061629molecular_functionRNA polymerase II-specific DNA-binding transcription factor binding
F0070062cellular_componentextracellular exosome
F0071286biological_processcellular response to magnesium ion
F0071320biological_processcellular response to cAMP
F0071466biological_processcellular response to xenobiotic stimulus
F0071475biological_processcellular hyperosmotic salinity response
F0071477biological_processcellular hypotonic salinity response
F0097403biological_processcellular response to raffinose
F1904628biological_processcellular response to phorbol 13-acetate 12-myristate
G0000122biological_processnegative regulation of transcription by RNA polymerase II
G0003824molecular_functioncatalytic activity
G0005515molecular_functionprotein binding
G0005615cellular_componentextracellular space
G0005634cellular_componentnucleus
G0005737cellular_componentcytoplasm
G0005829cellular_componentcytosol
G0005975biological_processcarbohydrate metabolic process
G0006000biological_processfructose metabolic process
G0006002biological_processfructose 6-phosphate metabolic process
G0006094biological_processgluconeogenesis
G0006111biological_processregulation of gluconeogenesis
G0016208molecular_functionAMP binding
G0016787molecular_functionhydrolase activity
G0016791molecular_functionphosphatase activity
G0030308biological_processnegative regulation of cell growth
G0030388biological_processfructose 1,6-bisphosphate metabolic process
G0031667biological_processresponse to nutrient levels
G0032869biological_processcellular response to insulin stimulus
G0042132molecular_functionfructose 1,6-bisphosphate 1-phosphatase activity
G0042578molecular_functionphosphoric ester hydrolase activity
G0042802molecular_functionidentical protein binding
G0045820biological_processnegative regulation of glycolytic process
G0046580biological_processnegative regulation of Ras protein signal transduction
G0046872molecular_functionmetal ion binding
G0048029molecular_functionmonosaccharide binding
G0061629molecular_functionRNA polymerase II-specific DNA-binding transcription factor binding
G0070062cellular_componentextracellular exosome
G0071286biological_processcellular response to magnesium ion
G0071320biological_processcellular response to cAMP
G0071466biological_processcellular response to xenobiotic stimulus
G0071475biological_processcellular hyperosmotic salinity response
G0071477biological_processcellular hypotonic salinity response
G0097403biological_processcellular response to raffinose
G1904628biological_processcellular response to phorbol 13-acetate 12-myristate
H0000122biological_processnegative regulation of transcription by RNA polymerase II
H0003824molecular_functioncatalytic activity
H0005515molecular_functionprotein binding
H0005615cellular_componentextracellular space
H0005634cellular_componentnucleus
H0005737cellular_componentcytoplasm
H0005829cellular_componentcytosol
H0005975biological_processcarbohydrate metabolic process
H0006000biological_processfructose metabolic process
H0006002biological_processfructose 6-phosphate metabolic process
H0006094biological_processgluconeogenesis
H0006111biological_processregulation of gluconeogenesis
H0016208molecular_functionAMP binding
H0016787molecular_functionhydrolase activity
H0016791molecular_functionphosphatase activity
H0030308biological_processnegative regulation of cell growth
H0030388biological_processfructose 1,6-bisphosphate metabolic process
H0031667biological_processresponse to nutrient levels
H0032869biological_processcellular response to insulin stimulus
H0042132molecular_functionfructose 1,6-bisphosphate 1-phosphatase activity
H0042578molecular_functionphosphoric ester hydrolase activity
H0042802molecular_functionidentical protein binding
H0045820biological_processnegative regulation of glycolytic process
H0046580biological_processnegative regulation of Ras protein signal transduction
H0046872molecular_functionmetal ion binding
H0048029molecular_functionmonosaccharide binding
H0061629molecular_functionRNA polymerase II-specific DNA-binding transcription factor binding
H0070062cellular_componentextracellular exosome
H0071286biological_processcellular response to magnesium ion
H0071320biological_processcellular response to cAMP
H0071466biological_processcellular response to xenobiotic stimulus
H0071475biological_processcellular hyperosmotic salinity response
H0071477biological_processcellular hypotonic salinity response
H0097403biological_processcellular response to raffinose
H1904628biological_processcellular response to phorbol 13-acetate 12-myristate
Functional Information from PDB Data
site_idAC1
Number of Residues15
Detailsbinding site for residue 967 A 401
ChainResidue
AVAL17
ALEU30
ATHR31
AHOH558
AHOH608
CTHR27
C967401
AMET18
AGLY21
AARG22
AALA24
AGLY26
ATHR27
AGLY28
AGLU29

site_idAC2
Number of Residues14
Detailsbinding site for residue 967 B 401
ChainResidue
BVAL17
BGLY21
BARG22
BALA24
BGLY26
BTHR27
BGLY28
BGLU29
BLEU30
BTHR31
BHOH534
DTHR27
DGLY28
D967401

site_idAC3
Number of Residues15
Detailsbinding site for residue 967 C 401
ChainResidue
ATHR27
AGLY28
A967401
CVAL17
CMET18
CGLY21
CARG22
CALA24
CGLY26
CTHR27
CGLY28
CGLU29
CLEU30
CTHR31
CHOH554

site_idAC4
Number of Residues15
Detailsbinding site for residue 967 D 401
ChainResidue
BTHR27
BGLY28
B967401
DVAL17
DGLY21
DARG22
DALA24
DGLY26
DTHR27
DGLY28
DGLU29
DLEU30
DTHR31
DHOH547
DHOH638

site_idAC5
Number of Residues14
Detailsbinding site for residue 967 E 401
ChainResidue
EVAL17
EGLY21
EARG22
EALA24
EGLY26
ETHR27
EGLY28
EGLU29
ELEU30
ETHR31
EHOH565
GTHR27
GGLY28
G967401

site_idAC6
Number of Residues15
Detailsbinding site for residue 967 F 401
ChainResidue
FVAL17
FMET18
FGLY21
FARG22
FALA24
FGLY26
FTHR27
FGLY28
FGLU29
FLEU30
FTHR31
FHOH529
HTHR27
HGLY28
H967401

site_idAC7
Number of Residues15
Detailsbinding site for residue 967 G 401
ChainResidue
GGLU29
GLEU30
GTHR31
GHOH550
ETHR27
EGLY28
E967401
GVAL17
GMET18
GGLY21
GARG22
GALA24
GGLY26
GTHR27
GGLY28

site_idAC8
Number of Residues14
Detailsbinding site for residue 967 H 401
ChainResidue
FTHR27
FGLY28
F967401
HVAL17
HGLY21
HARG22
HALA24
HGLY26
HTHR27
HGLY28
HGLU29
HLEU30
HTHR31
HHOH518

Functional Information from PROSITE/UniProt
site_idPS00124
Number of Residues13
DetailsFBPASE Fructose-1-6-bisphosphatase active site. GKLrlLYEcnPMA
ChainResidueDetails
AGLY273-ALA285

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues80
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"7809062","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1FTA","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI3
Number of Residues104
DetailsBinding site: {"evidences":[{"source":"UniProtKB","id":"P00636","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI4
Number of Residues8
DetailsModified residue: {"description":"N6-succinyllysine","evidences":[{"source":"UniProtKB","id":"Q9QXD6","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI5
Number of Residues16
DetailsModified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"Q9QXD6","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI6
Number of Residues8
DetailsModified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

238582

PDB entries from 2025-07-09

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