5Q08

Human liver fructose-1,6-bisphosphatase 1 (fructose 1,6-bisphosphate 1-phosphatase, E.C.3.1.3.11) complexed with the allosteric inhibitor 1-(1-benzothiophen-3-ylsulfonyl)-3-(5-bromo-1,3-thiazol-2-yl)urea

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000122	biological_process	negative regulation of transcription by RNA polymerase II
A	0003824	molecular_function	catalytic activity
A	0005515	molecular_function	protein binding
A	0005615	cellular_component	extracellular space
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0005975	biological_process	carbohydrate metabolic process
A	0006000	biological_process	fructose metabolic process
A	0006002	biological_process	fructose 6-phosphate metabolic process
A	0006094	biological_process	gluconeogenesis
A	0006111	biological_process	regulation of gluconeogenesis
A	0016208	molecular_function	AMP binding
A	0016787	molecular_function	hydrolase activity
A	0016791	molecular_function	phosphatase activity
A	0030308	biological_process	negative regulation of cell growth
A	0030388	biological_process	fructose 1,6-bisphosphate metabolic process
A	0031667	biological_process	response to nutrient levels
A	0032869	biological_process	cellular response to insulin stimulus
A	0042132	molecular_function	fructose 1,6-bisphosphate 1-phosphatase activity
A	0042578	molecular_function	phosphoric ester hydrolase activity
A	0042802	molecular_function	identical protein binding
A	0045820	biological_process	negative regulation of glycolytic process
A	0046580	biological_process	negative regulation of Ras protein signal transduction
A	0046872	molecular_function	metal ion binding
A	0048029	molecular_function	monosaccharide binding
A	0061629	molecular_function	RNA polymerase II-specific DNA-binding transcription factor binding
A	0070062	cellular_component	extracellular exosome
A	0071286	biological_process	cellular response to magnesium ion
A	0071320	biological_process	cellular response to cAMP
A	0071466	biological_process	cellular response to xenobiotic stimulus
A	0071475	biological_process	cellular hyperosmotic salinity response
A	0071477	biological_process	cellular hypotonic salinity response
A	0097403	biological_process	cellular response to raffinose
A	1904628	biological_process	cellular response to phorbol 13-acetate 12-myristate
B	0000122	biological_process	negative regulation of transcription by RNA polymerase II
B	0003824	molecular_function	catalytic activity
B	0005515	molecular_function	protein binding
B	0005615	cellular_component	extracellular space
B	0005634	cellular_component	nucleus
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0005975	biological_process	carbohydrate metabolic process
B	0006000	biological_process	fructose metabolic process
B	0006002	biological_process	fructose 6-phosphate metabolic process
B	0006094	biological_process	gluconeogenesis
B	0006111	biological_process	regulation of gluconeogenesis
B	0016208	molecular_function	AMP binding
B	0016787	molecular_function	hydrolase activity
B	0016791	molecular_function	phosphatase activity
B	0030308	biological_process	negative regulation of cell growth
B	0030388	biological_process	fructose 1,6-bisphosphate metabolic process
B	0031667	biological_process	response to nutrient levels
B	0032869	biological_process	cellular response to insulin stimulus
B	0042132	molecular_function	fructose 1,6-bisphosphate 1-phosphatase activity
B	0042578	molecular_function	phosphoric ester hydrolase activity
B	0042802	molecular_function	identical protein binding
B	0045820	biological_process	negative regulation of glycolytic process
B	0046580	biological_process	negative regulation of Ras protein signal transduction
B	0046872	molecular_function	metal ion binding
B	0048029	molecular_function	monosaccharide binding
B	0061629	molecular_function	RNA polymerase II-specific DNA-binding transcription factor binding
B	0070062	cellular_component	extracellular exosome
B	0071286	biological_process	cellular response to magnesium ion
B	0071320	biological_process	cellular response to cAMP
B	0071466	biological_process	cellular response to xenobiotic stimulus
B	0071475	biological_process	cellular hyperosmotic salinity response
B	0071477	biological_process	cellular hypotonic salinity response
B	0097403	biological_process	cellular response to raffinose
B	1904628	biological_process	cellular response to phorbol 13-acetate 12-myristate
C	0000122	biological_process	negative regulation of transcription by RNA polymerase II
C	0003824	molecular_function	catalytic activity
C	0005515	molecular_function	protein binding
C	0005615	cellular_component	extracellular space
C	0005634	cellular_component	nucleus
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0005975	biological_process	carbohydrate metabolic process
C	0006000	biological_process	fructose metabolic process
C	0006002	biological_process	fructose 6-phosphate metabolic process
C	0006094	biological_process	gluconeogenesis
C	0006111	biological_process	regulation of gluconeogenesis
C	0016208	molecular_function	AMP binding
C	0016787	molecular_function	hydrolase activity
C	0016791	molecular_function	phosphatase activity
C	0030308	biological_process	negative regulation of cell growth
C	0030388	biological_process	fructose 1,6-bisphosphate metabolic process
C	0031667	biological_process	response to nutrient levels
C	0032869	biological_process	cellular response to insulin stimulus
C	0042132	molecular_function	fructose 1,6-bisphosphate 1-phosphatase activity
C	0042578	molecular_function	phosphoric ester hydrolase activity
C	0042802	molecular_function	identical protein binding
C	0045820	biological_process	negative regulation of glycolytic process
C	0046580	biological_process	negative regulation of Ras protein signal transduction
C	0046872	molecular_function	metal ion binding
C	0048029	molecular_function	monosaccharide binding
C	0061629	molecular_function	RNA polymerase II-specific DNA-binding transcription factor binding
C	0070062	cellular_component	extracellular exosome
C	0071286	biological_process	cellular response to magnesium ion
C	0071320	biological_process	cellular response to cAMP
C	0071466	biological_process	cellular response to xenobiotic stimulus
C	0071475	biological_process	cellular hyperosmotic salinity response
C	0071477	biological_process	cellular hypotonic salinity response
C	0097403	biological_process	cellular response to raffinose
C	1904628	biological_process	cellular response to phorbol 13-acetate 12-myristate
D	0000122	biological_process	negative regulation of transcription by RNA polymerase II
D	0003824	molecular_function	catalytic activity
D	0005515	molecular_function	protein binding
D	0005615	cellular_component	extracellular space
D	0005634	cellular_component	nucleus
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0005975	biological_process	carbohydrate metabolic process
D	0006000	biological_process	fructose metabolic process
D	0006002	biological_process	fructose 6-phosphate metabolic process
D	0006094	biological_process	gluconeogenesis
D	0006111	biological_process	regulation of gluconeogenesis
D	0016208	molecular_function	AMP binding
D	0016787	molecular_function	hydrolase activity
D	0016791	molecular_function	phosphatase activity
D	0030308	biological_process	negative regulation of cell growth
D	0030388	biological_process	fructose 1,6-bisphosphate metabolic process
D	0031667	biological_process	response to nutrient levels
D	0032869	biological_process	cellular response to insulin stimulus
D	0042132	molecular_function	fructose 1,6-bisphosphate 1-phosphatase activity
D	0042578	molecular_function	phosphoric ester hydrolase activity
D	0042802	molecular_function	identical protein binding
D	0045820	biological_process	negative regulation of glycolytic process
D	0046580	biological_process	negative regulation of Ras protein signal transduction
D	0046872	molecular_function	metal ion binding
D	0048029	molecular_function	monosaccharide binding
D	0061629	molecular_function	RNA polymerase II-specific DNA-binding transcription factor binding
D	0070062	cellular_component	extracellular exosome
D	0071286	biological_process	cellular response to magnesium ion
D	0071320	biological_process	cellular response to cAMP
D	0071466	biological_process	cellular response to xenobiotic stimulus
D	0071475	biological_process	cellular hyperosmotic salinity response
D	0071477	biological_process	cellular hypotonic salinity response
D	0097403	biological_process	cellular response to raffinose
D	1904628	biological_process	cellular response to phorbol 13-acetate 12-myristate
E	0000122	biological_process	negative regulation of transcription by RNA polymerase II
E	0003824	molecular_function	catalytic activity
E	0005515	molecular_function	protein binding
E	0005615	cellular_component	extracellular space
E	0005634	cellular_component	nucleus
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0005975	biological_process	carbohydrate metabolic process
E	0006000	biological_process	fructose metabolic process
E	0006002	biological_process	fructose 6-phosphate metabolic process
E	0006094	biological_process	gluconeogenesis
E	0006111	biological_process	regulation of gluconeogenesis
E	0016208	molecular_function	AMP binding
E	0016787	molecular_function	hydrolase activity
E	0016791	molecular_function	phosphatase activity
E	0030308	biological_process	negative regulation of cell growth
E	0030388	biological_process	fructose 1,6-bisphosphate metabolic process
E	0031667	biological_process	response to nutrient levels
E	0032869	biological_process	cellular response to insulin stimulus
E	0042132	molecular_function	fructose 1,6-bisphosphate 1-phosphatase activity
E	0042578	molecular_function	phosphoric ester hydrolase activity
E	0042802	molecular_function	identical protein binding
E	0045820	biological_process	negative regulation of glycolytic process
E	0046580	biological_process	negative regulation of Ras protein signal transduction
E	0046872	molecular_function	metal ion binding
E	0048029	molecular_function	monosaccharide binding
E	0061629	molecular_function	RNA polymerase II-specific DNA-binding transcription factor binding
E	0070062	cellular_component	extracellular exosome
E	0071286	biological_process	cellular response to magnesium ion
E	0071320	biological_process	cellular response to cAMP
E	0071466	biological_process	cellular response to xenobiotic stimulus
E	0071475	biological_process	cellular hyperosmotic salinity response
E	0071477	biological_process	cellular hypotonic salinity response
E	0097403	biological_process	cellular response to raffinose
E	1904628	biological_process	cellular response to phorbol 13-acetate 12-myristate
F	0000122	biological_process	negative regulation of transcription by RNA polymerase II
F	0003824	molecular_function	catalytic activity
F	0005515	molecular_function	protein binding
F	0005615	cellular_component	extracellular space
F	0005634	cellular_component	nucleus
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0005975	biological_process	carbohydrate metabolic process
F	0006000	biological_process	fructose metabolic process
F	0006002	biological_process	fructose 6-phosphate metabolic process
F	0006094	biological_process	gluconeogenesis
F	0006111	biological_process	regulation of gluconeogenesis
F	0016208	molecular_function	AMP binding
F	0016787	molecular_function	hydrolase activity
F	0016791	molecular_function	phosphatase activity
F	0030308	biological_process	negative regulation of cell growth
F	0030388	biological_process	fructose 1,6-bisphosphate metabolic process
F	0031667	biological_process	response to nutrient levels
F	0032869	biological_process	cellular response to insulin stimulus
F	0042132	molecular_function	fructose 1,6-bisphosphate 1-phosphatase activity
F	0042578	molecular_function	phosphoric ester hydrolase activity
F	0042802	molecular_function	identical protein binding
F	0045820	biological_process	negative regulation of glycolytic process
F	0046580	biological_process	negative regulation of Ras protein signal transduction
F	0046872	molecular_function	metal ion binding
F	0048029	molecular_function	monosaccharide binding
F	0061629	molecular_function	RNA polymerase II-specific DNA-binding transcription factor binding
F	0070062	cellular_component	extracellular exosome
F	0071286	biological_process	cellular response to magnesium ion
F	0071320	biological_process	cellular response to cAMP
F	0071466	biological_process	cellular response to xenobiotic stimulus
F	0071475	biological_process	cellular hyperosmotic salinity response
F	0071477	biological_process	cellular hypotonic salinity response
F	0097403	biological_process	cellular response to raffinose
F	1904628	biological_process	cellular response to phorbol 13-acetate 12-myristate
G	0000122	biological_process	negative regulation of transcription by RNA polymerase II
G	0003824	molecular_function	catalytic activity
G	0005515	molecular_function	protein binding
G	0005615	cellular_component	extracellular space
G	0005634	cellular_component	nucleus
G	0005737	cellular_component	cytoplasm
G	0005829	cellular_component	cytosol
G	0005975	biological_process	carbohydrate metabolic process
G	0006000	biological_process	fructose metabolic process
G	0006002	biological_process	fructose 6-phosphate metabolic process
G	0006094	biological_process	gluconeogenesis
G	0006111	biological_process	regulation of gluconeogenesis
G	0016208	molecular_function	AMP binding
G	0016787	molecular_function	hydrolase activity
G	0016791	molecular_function	phosphatase activity
G	0030308	biological_process	negative regulation of cell growth
G	0030388	biological_process	fructose 1,6-bisphosphate metabolic process
G	0031667	biological_process	response to nutrient levels
G	0032869	biological_process	cellular response to insulin stimulus
G	0042132	molecular_function	fructose 1,6-bisphosphate 1-phosphatase activity
G	0042578	molecular_function	phosphoric ester hydrolase activity
G	0042802	molecular_function	identical protein binding
G	0045820	biological_process	negative regulation of glycolytic process
G	0046580	biological_process	negative regulation of Ras protein signal transduction
G	0046872	molecular_function	metal ion binding
G	0048029	molecular_function	monosaccharide binding
G	0061629	molecular_function	RNA polymerase II-specific DNA-binding transcription factor binding
G	0070062	cellular_component	extracellular exosome
G	0071286	biological_process	cellular response to magnesium ion
G	0071320	biological_process	cellular response to cAMP
G	0071466	biological_process	cellular response to xenobiotic stimulus
G	0071475	biological_process	cellular hyperosmotic salinity response
G	0071477	biological_process	cellular hypotonic salinity response
G	0097403	biological_process	cellular response to raffinose
G	1904628	biological_process	cellular response to phorbol 13-acetate 12-myristate
H	0000122	biological_process	negative regulation of transcription by RNA polymerase II
H	0003824	molecular_function	catalytic activity
H	0005515	molecular_function	protein binding
H	0005615	cellular_component	extracellular space
H	0005634	cellular_component	nucleus
H	0005737	cellular_component	cytoplasm
H	0005829	cellular_component	cytosol
H	0005975	biological_process	carbohydrate metabolic process
H	0006000	biological_process	fructose metabolic process
H	0006002	biological_process	fructose 6-phosphate metabolic process
H	0006094	biological_process	gluconeogenesis
H	0006111	biological_process	regulation of gluconeogenesis
H	0016208	molecular_function	AMP binding
H	0016787	molecular_function	hydrolase activity
H	0016791	molecular_function	phosphatase activity
H	0030308	biological_process	negative regulation of cell growth
H	0030388	biological_process	fructose 1,6-bisphosphate metabolic process
H	0031667	biological_process	response to nutrient levels
H	0032869	biological_process	cellular response to insulin stimulus
H	0042132	molecular_function	fructose 1,6-bisphosphate 1-phosphatase activity
H	0042578	molecular_function	phosphoric ester hydrolase activity
H	0042802	molecular_function	identical protein binding
H	0045820	biological_process	negative regulation of glycolytic process
H	0046580	biological_process	negative regulation of Ras protein signal transduction
H	0046872	molecular_function	metal ion binding
H	0048029	molecular_function	monosaccharide binding
H	0061629	molecular_function	RNA polymerase II-specific DNA-binding transcription factor binding
H	0070062	cellular_component	extracellular exosome
H	0071286	biological_process	cellular response to magnesium ion
H	0071320	biological_process	cellular response to cAMP
H	0071466	biological_process	cellular response to xenobiotic stimulus
H	0071475	biological_process	cellular hyperosmotic salinity response
H	0071477	biological_process	cellular hypotonic salinity response
H	0097403	biological_process	cellular response to raffinose
H	1904628	biological_process	cellular response to phorbol 13-acetate 12-myristate

Functional Information from PDB Data

site_id	AC1
Number of Residues	15
Details	binding site for residue 967 A 401

Chain	Residue
A	VAL17
A	LEU30
A	THR31
A	HOH558
A	HOH608
C	THR27
C	967401
A	MET18
A	GLY21
A	ARG22
A	ALA24
A	GLY26
A	THR27
A	GLY28
A	GLU29

---

site_id	AC2
Number of Residues	14
Details	binding site for residue 967 B 401

Chain	Residue
B	VAL17
B	GLY21
B	ARG22
B	ALA24
B	GLY26
B	THR27
B	GLY28
B	GLU29
B	LEU30
B	THR31
B	HOH534
D	THR27
D	GLY28
D	967401

---

site_id	AC3
Number of Residues	15
Details	binding site for residue 967 C 401

Chain	Residue
A	THR27
A	GLY28
A	967401
C	VAL17
C	MET18
C	GLY21
C	ARG22
C	ALA24
C	GLY26
C	THR27
C	GLY28
C	GLU29
C	LEU30
C	THR31
C	HOH554

---

site_id	AC4
Number of Residues	15
Details	binding site for residue 967 D 401

Chain	Residue
B	THR27
B	GLY28
B	967401
D	VAL17
D	GLY21
D	ARG22
D	ALA24
D	GLY26
D	THR27
D	GLY28
D	GLU29
D	LEU30
D	THR31
D	HOH547
D	HOH638

---

site_id	AC5
Number of Residues	14
Details	binding site for residue 967 E 401

Chain	Residue
E	VAL17
E	GLY21
E	ARG22
E	ALA24
E	GLY26
E	THR27
E	GLY28
E	GLU29
E	LEU30
E	THR31
E	HOH565
G	THR27
G	GLY28
G	967401

---

site_id	AC6
Number of Residues	15
Details	binding site for residue 967 F 401

Chain	Residue
F	VAL17
F	MET18
F	GLY21
F	ARG22
F	ALA24
F	GLY26
F	THR27
F	GLY28
F	GLU29
F	LEU30
F	THR31
F	HOH529
H	THR27
H	GLY28
H	967401

---

site_id	AC7
Number of Residues	15
Details	binding site for residue 967 G 401

Chain	Residue
G	GLU29
G	LEU30
G	THR31
G	HOH550
E	THR27
E	GLY28
E	967401
G	VAL17
G	MET18
G	GLY21
G	ARG22
G	ALA24
G	GLY26
G	THR27
G	GLY28

---

site_id	AC8
Number of Residues	14
Details	binding site for residue 967 H 401

Chain	Residue
F	THR27
F	GLY28
F	967401
H	VAL17
H	GLY21
H	ARG22
H	ALA24
H	GLY26
H	THR27
H	GLY28
H	GLU29
H	LEU30
H	THR31
H	HOH518

---

Functional Information from PROSITE/UniProt

site_id	PS00124
Number of Residues	13
Details	FBPASE Fructose-1-6-bisphosphatase active site. GKLrlLYEcnPMA

Chain	Residue	Details
A	GLY273-ALA285

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	80
Details	Binding site: {"evidences":[{"source":"PubMed","id":"7809062","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1FTA","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	104
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P00636","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	8
Details	Modified residue: {"description":"N6-succinyllysine","evidences":[{"source":"UniProtKB","id":"Q9QXD6","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	16
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"Q9QXD6","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	8
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---