5PZU

Human liver fructose-1,6-bisphosphatase 1 (fructose 1,6-bisphosphate 1-phosphatase, E.C.3.1.3.11) complexed with the allosteric inhibitor [5-[2-amino-5-(2-methylpropyl)-1,3-thiazol-4-yl]furan-2-yl]phosphonic acid

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Functional Information from GO Data

ChainGOidnamespacecontents
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0070062cellular_componentextracellular exosome
A0005634cellular_componentnucleus
A0016208molecular_functionAMP binding
A0042132molecular_functionfructose 1,6-bisphosphate 1-phosphatase activity
A0042802molecular_functionidentical protein binding
A0046872molecular_functionmetal ion binding
A0048029molecular_functionmonosaccharide binding
A0001085molecular_functionRNA polymerase II transcription factor binding
A0035690biological_processcellular response to drug
A0071286biological_processcellular response to magnesium ion
A0016311biological_processdephosphorylation
A0030388biological_processfructose 1,6-bisphosphate metabolic process
A0006002biological_processfructose 6-phosphate metabolic process
A0006000biological_processfructose metabolic process
A0006094biological_processgluconeogenesis
A0030308biological_processnegative regulation of cell growth
A0045820biological_processnegative regulation of glycolytic process
A0046580biological_processnegative regulation of Ras protein signal transduction
A0000122biological_processnegative regulation of transcription by RNA polymerase II
A0006111biological_processregulation of gluconeogenesis
A0005986biological_processsucrose biosynthetic process
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0070062cellular_componentextracellular exosome
B0005634cellular_componentnucleus
B0016208molecular_functionAMP binding
B0042132molecular_functionfructose 1,6-bisphosphate 1-phosphatase activity
B0042802molecular_functionidentical protein binding
B0046872molecular_functionmetal ion binding
B0048029molecular_functionmonosaccharide binding
B0001085molecular_functionRNA polymerase II transcription factor binding
B0035690biological_processcellular response to drug
B0071286biological_processcellular response to magnesium ion
B0016311biological_processdephosphorylation
B0030388biological_processfructose 1,6-bisphosphate metabolic process
B0006002biological_processfructose 6-phosphate metabolic process
B0006000biological_processfructose metabolic process
B0006094biological_processgluconeogenesis
B0030308biological_processnegative regulation of cell growth
B0045820biological_processnegative regulation of glycolytic process
B0046580biological_processnegative regulation of Ras protein signal transduction
B0000122biological_processnegative regulation of transcription by RNA polymerase II
B0006111biological_processregulation of gluconeogenesis
B0005986biological_processsucrose biosynthetic process
C0005737cellular_componentcytoplasm
C0005829cellular_componentcytosol
C0070062cellular_componentextracellular exosome
C0005634cellular_componentnucleus
C0016208molecular_functionAMP binding
C0042132molecular_functionfructose 1,6-bisphosphate 1-phosphatase activity
C0042802molecular_functionidentical protein binding
C0046872molecular_functionmetal ion binding
C0048029molecular_functionmonosaccharide binding
C0001085molecular_functionRNA polymerase II transcription factor binding
C0035690biological_processcellular response to drug
C0071286biological_processcellular response to magnesium ion
C0016311biological_processdephosphorylation
C0030388biological_processfructose 1,6-bisphosphate metabolic process
C0006002biological_processfructose 6-phosphate metabolic process
C0006000biological_processfructose metabolic process
C0006094biological_processgluconeogenesis
C0030308biological_processnegative regulation of cell growth
C0045820biological_processnegative regulation of glycolytic process
C0046580biological_processnegative regulation of Ras protein signal transduction
C0000122biological_processnegative regulation of transcription by RNA polymerase II
C0006111biological_processregulation of gluconeogenesis
C0005986biological_processsucrose biosynthetic process
D0005737cellular_componentcytoplasm
D0005829cellular_componentcytosol
D0070062cellular_componentextracellular exosome
D0005634cellular_componentnucleus
D0016208molecular_functionAMP binding
D0042132molecular_functionfructose 1,6-bisphosphate 1-phosphatase activity
D0042802molecular_functionidentical protein binding
D0046872molecular_functionmetal ion binding
D0048029molecular_functionmonosaccharide binding
D0001085molecular_functionRNA polymerase II transcription factor binding
D0035690biological_processcellular response to drug
D0071286biological_processcellular response to magnesium ion
D0016311biological_processdephosphorylation
D0030388biological_processfructose 1,6-bisphosphate metabolic process
D0006002biological_processfructose 6-phosphate metabolic process
D0006000biological_processfructose metabolic process
D0006094biological_processgluconeogenesis
D0030308biological_processnegative regulation of cell growth
D0045820biological_processnegative regulation of glycolytic process
D0046580biological_processnegative regulation of Ras protein signal transduction
D0000122biological_processnegative regulation of transcription by RNA polymerase II
D0006111biological_processregulation of gluconeogenesis
D0005986biological_processsucrose biosynthetic process
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Functional Information from PDB Data

site_idNumber of ResiduesDetails
AC115binding site for residue 94D A 401
ChainResidue
AVAL17
AGLU20
AGLY21
AGLY26
ATHR27
AGLY28
AGLU29
ALEU30
ATHR31
ALYS112
ATYR113
AARG140
AVAL160
AHOH604
AHOH621

AC214binding site for residue 94D B 401
ChainResidue
BVAL17
BGLY21
BGLY26
BTHR27
BGLY28
BGLU29
BLEU30
BTHR31
BLYS112
BTYR113
BARG140
BMET177
BHOH597
BHOH610

AC315binding site for residue 94D C 401
ChainResidue
CVAL17
CGLU20
CGLY21
CGLY26
CTHR27
CGLY28
CGLU29
CLEU30
CTHR31
CLYS112
CTYR113
CVAL160
CHOH601
CHOH646
CHOH671

AC414binding site for residue 94D D 401
ChainResidue
DVAL17
DGLU20
DGLY21
DGLY26
DTHR27
DGLY28
DGLU29
DLEU30
DTHR31
DLYS112
DTYR113
DARG140
DHOH585
DHOH599

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Functional Information from PDB atom coordinates for the "HETATM" binding sites

site_idNumber of ResiduesDetails
94D_5pzu_A_40118{5-[2-amino-5-(2-methylpropyl)-1,3-thiazol-4-yl]furan-2-yl}phosphonic acid binding site
ChainResidueligand
AVAL17-MET1894D: {5-[2-amino-5-(2-methylpropyl)-1,3-thiazol-4-yl]furan-2-yl}phosphonic acid
AGLU20-GLY2194D: {5-[2-amino-5-(2-methylpropyl)-1,3-thiazol-4-yl]furan-2-yl}phosphonic acid
AALA2494D: {5-[2-amino-5-(2-methylpropyl)-1,3-thiazol-4-yl]furan-2-yl}phosphonic acid
AGLY26-THR3194D: {5-[2-amino-5-(2-methylpropyl)-1,3-thiazol-4-yl]furan-2-yl}phosphonic acid
ALEU3494D: {5-[2-amino-5-(2-methylpropyl)-1,3-thiazol-4-yl]furan-2-yl}phosphonic acid
ALYS112-TYR11394D: {5-[2-amino-5-(2-methylpropyl)-1,3-thiazol-4-yl]furan-2-yl}phosphonic acid
AARG14094D: {5-[2-amino-5-(2-methylpropyl)-1,3-thiazol-4-yl]furan-2-yl}phosphonic acid
AVAL16094D: {5-[2-amino-5-(2-methylpropyl)-1,3-thiazol-4-yl]furan-2-yl}phosphonic acid
AMET177-ASP17894D: {5-[2-amino-5-(2-methylpropyl)-1,3-thiazol-4-yl]furan-2-yl}phosphonic acid

94D_5pzu_B_40118{5-[2-amino-5-(2-methylpropyl)-1,3-thiazol-4-yl]furan-2-yl}phosphonic acid binding site
ChainResidueligand
BVAL17-MET1894D: {5-[2-amino-5-(2-methylpropyl)-1,3-thiazol-4-yl]furan-2-yl}phosphonic acid
BGLU20-GLY2194D: {5-[2-amino-5-(2-methylpropyl)-1,3-thiazol-4-yl]furan-2-yl}phosphonic acid
BALA2494D: {5-[2-amino-5-(2-methylpropyl)-1,3-thiazol-4-yl]furan-2-yl}phosphonic acid
BGLY26-THR3194D: {5-[2-amino-5-(2-methylpropyl)-1,3-thiazol-4-yl]furan-2-yl}phosphonic acid
BLEU3494D: {5-[2-amino-5-(2-methylpropyl)-1,3-thiazol-4-yl]furan-2-yl}phosphonic acid
BLYS112-TYR11394D: {5-[2-amino-5-(2-methylpropyl)-1,3-thiazol-4-yl]furan-2-yl}phosphonic acid
BARG14094D: {5-[2-amino-5-(2-methylpropyl)-1,3-thiazol-4-yl]furan-2-yl}phosphonic acid
BVAL16094D: {5-[2-amino-5-(2-methylpropyl)-1,3-thiazol-4-yl]furan-2-yl}phosphonic acid
BMET177-ASP17894D: {5-[2-amino-5-(2-methylpropyl)-1,3-thiazol-4-yl]furan-2-yl}phosphonic acid

94D_5pzu_C_40118{5-[2-amino-5-(2-methylpropyl)-1,3-thiazol-4-yl]furan-2-yl}phosphonic acid binding site
ChainResidueligand
CVAL17-MET1894D: {5-[2-amino-5-(2-methylpropyl)-1,3-thiazol-4-yl]furan-2-yl}phosphonic acid
CGLU20-GLY2194D: {5-[2-amino-5-(2-methylpropyl)-1,3-thiazol-4-yl]furan-2-yl}phosphonic acid
CALA2494D: {5-[2-amino-5-(2-methylpropyl)-1,3-thiazol-4-yl]furan-2-yl}phosphonic acid
CGLY26-THR3194D: {5-[2-amino-5-(2-methylpropyl)-1,3-thiazol-4-yl]furan-2-yl}phosphonic acid
CLEU3494D: {5-[2-amino-5-(2-methylpropyl)-1,3-thiazol-4-yl]furan-2-yl}phosphonic acid
CLYS112-TYR11394D: {5-[2-amino-5-(2-methylpropyl)-1,3-thiazol-4-yl]furan-2-yl}phosphonic acid
CARG14094D: {5-[2-amino-5-(2-methylpropyl)-1,3-thiazol-4-yl]furan-2-yl}phosphonic acid
CVAL16094D: {5-[2-amino-5-(2-methylpropyl)-1,3-thiazol-4-yl]furan-2-yl}phosphonic acid
CMET177-ASP17894D: {5-[2-amino-5-(2-methylpropyl)-1,3-thiazol-4-yl]furan-2-yl}phosphonic acid

94D_5pzu_D_40118{5-[2-amino-5-(2-methylpropyl)-1,3-thiazol-4-yl]furan-2-yl}phosphonic acid binding site
ChainResidueligand
DVAL17-MET1894D: {5-[2-amino-5-(2-methylpropyl)-1,3-thiazol-4-yl]furan-2-yl}phosphonic acid
DGLU20-GLY2194D: {5-[2-amino-5-(2-methylpropyl)-1,3-thiazol-4-yl]furan-2-yl}phosphonic acid
DALA2494D: {5-[2-amino-5-(2-methylpropyl)-1,3-thiazol-4-yl]furan-2-yl}phosphonic acid
DGLY26-THR3194D: {5-[2-amino-5-(2-methylpropyl)-1,3-thiazol-4-yl]furan-2-yl}phosphonic acid
DLEU3494D: {5-[2-amino-5-(2-methylpropyl)-1,3-thiazol-4-yl]furan-2-yl}phosphonic acid
DLYS112-TYR11394D: {5-[2-amino-5-(2-methylpropyl)-1,3-thiazol-4-yl]furan-2-yl}phosphonic acid
DARG14094D: {5-[2-amino-5-(2-methylpropyl)-1,3-thiazol-4-yl]furan-2-yl}phosphonic acid
DVAL16094D: {5-[2-amino-5-(2-methylpropyl)-1,3-thiazol-4-yl]furan-2-yl}phosphonic acid
DMET177-ASP17894D: {5-[2-amino-5-(2-methylpropyl)-1,3-thiazol-4-yl]furan-2-yl}phosphonic acid

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Functional Information from PROSITE/UniProt

site_idNumber of ResiduesDetails
PS0012452Fructose-1-6-bisphosphatase active site.[AG]-[RK]-[LI]-x(1,2)-[LIV]-[FY]-E-x(2)-P-[LIVM]-[GSA].
ChainResidueDetails
AGLY273-ALA285
BGLY273-ALA285
CGLY273-ALA285
DGLY273-ALA285

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Functional Information from SwissProt/UniProt

site_idNumber of ResiduesDetails
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Catalytic Information from CSA

site_idNumber of ResiduesDetails