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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

5PZQ

Human liver fructose-1,6-bisphosphatase 1 (fructose 1,6-bisphosphate 1-phosphatase, E.C.3.1.3.11) complexed with the allosteric inhibitor 2-(4-methoxyphenyl)furan-3,4-dicarboxylic acid

Functional Information from GO Data
ChainGOidnamespacecontents
A0000122biological_processnegative regulation of transcription by RNA polymerase II
A0003824molecular_functioncatalytic activity
A0005515molecular_functionprotein binding
A0005615cellular_componentextracellular space
A0005634cellular_componentnucleus
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0005975biological_processcarbohydrate metabolic process
A0006000biological_processfructose metabolic process
A0006002biological_processfructose 6-phosphate metabolic process
A0006094biological_processgluconeogenesis
A0006111biological_processregulation of gluconeogenesis
A0016208molecular_functionAMP binding
A0016787molecular_functionhydrolase activity
A0016791molecular_functionphosphatase activity
A0030308biological_processnegative regulation of cell growth
A0030388biological_processfructose 1,6-bisphosphate metabolic process
A0031667biological_processresponse to nutrient levels
A0032869biological_processcellular response to insulin stimulus
A0042132molecular_functionfructose 1,6-bisphosphate 1-phosphatase activity
A0042578molecular_functionphosphoric ester hydrolase activity
A0042802molecular_functionidentical protein binding
A0045820biological_processnegative regulation of glycolytic process
A0046580biological_processnegative regulation of Ras protein signal transduction
A0046872molecular_functionmetal ion binding
A0048029molecular_functionmonosaccharide binding
A0061629molecular_functionRNA polymerase II-specific DNA-binding transcription factor binding
A0070062cellular_componentextracellular exosome
A0071286biological_processcellular response to magnesium ion
A0071320biological_processcellular response to cAMP
A0071466biological_processcellular response to xenobiotic stimulus
A0071475biological_processcellular hyperosmotic salinity response
A0071477biological_processcellular hypotonic salinity response
A0097403biological_processcellular response to raffinose
A1904628biological_processcellular response to phorbol 13-acetate 12-myristate
B0000122biological_processnegative regulation of transcription by RNA polymerase II
B0003824molecular_functioncatalytic activity
B0005515molecular_functionprotein binding
B0005615cellular_componentextracellular space
B0005634cellular_componentnucleus
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0005975biological_processcarbohydrate metabolic process
B0006000biological_processfructose metabolic process
B0006002biological_processfructose 6-phosphate metabolic process
B0006094biological_processgluconeogenesis
B0006111biological_processregulation of gluconeogenesis
B0016208molecular_functionAMP binding
B0016787molecular_functionhydrolase activity
B0016791molecular_functionphosphatase activity
B0030308biological_processnegative regulation of cell growth
B0030388biological_processfructose 1,6-bisphosphate metabolic process
B0031667biological_processresponse to nutrient levels
B0032869biological_processcellular response to insulin stimulus
B0042132molecular_functionfructose 1,6-bisphosphate 1-phosphatase activity
B0042578molecular_functionphosphoric ester hydrolase activity
B0042802molecular_functionidentical protein binding
B0045820biological_processnegative regulation of glycolytic process
B0046580biological_processnegative regulation of Ras protein signal transduction
B0046872molecular_functionmetal ion binding
B0048029molecular_functionmonosaccharide binding
B0061629molecular_functionRNA polymerase II-specific DNA-binding transcription factor binding
B0070062cellular_componentextracellular exosome
B0071286biological_processcellular response to magnesium ion
B0071320biological_processcellular response to cAMP
B0071466biological_processcellular response to xenobiotic stimulus
B0071475biological_processcellular hyperosmotic salinity response
B0071477biological_processcellular hypotonic salinity response
B0097403biological_processcellular response to raffinose
B1904628biological_processcellular response to phorbol 13-acetate 12-myristate
C0000122biological_processnegative regulation of transcription by RNA polymerase II
C0003824molecular_functioncatalytic activity
C0005515molecular_functionprotein binding
C0005615cellular_componentextracellular space
C0005634cellular_componentnucleus
C0005737cellular_componentcytoplasm
C0005829cellular_componentcytosol
C0005975biological_processcarbohydrate metabolic process
C0006000biological_processfructose metabolic process
C0006002biological_processfructose 6-phosphate metabolic process
C0006094biological_processgluconeogenesis
C0006111biological_processregulation of gluconeogenesis
C0016208molecular_functionAMP binding
C0016787molecular_functionhydrolase activity
C0016791molecular_functionphosphatase activity
C0030308biological_processnegative regulation of cell growth
C0030388biological_processfructose 1,6-bisphosphate metabolic process
C0031667biological_processresponse to nutrient levels
C0032869biological_processcellular response to insulin stimulus
C0042132molecular_functionfructose 1,6-bisphosphate 1-phosphatase activity
C0042578molecular_functionphosphoric ester hydrolase activity
C0042802molecular_functionidentical protein binding
C0045820biological_processnegative regulation of glycolytic process
C0046580biological_processnegative regulation of Ras protein signal transduction
C0046872molecular_functionmetal ion binding
C0048029molecular_functionmonosaccharide binding
C0061629molecular_functionRNA polymerase II-specific DNA-binding transcription factor binding
C0070062cellular_componentextracellular exosome
C0071286biological_processcellular response to magnesium ion
C0071320biological_processcellular response to cAMP
C0071466biological_processcellular response to xenobiotic stimulus
C0071475biological_processcellular hyperosmotic salinity response
C0071477biological_processcellular hypotonic salinity response
C0097403biological_processcellular response to raffinose
C1904628biological_processcellular response to phorbol 13-acetate 12-myristate
D0000122biological_processnegative regulation of transcription by RNA polymerase II
D0003824molecular_functioncatalytic activity
D0005515molecular_functionprotein binding
D0005615cellular_componentextracellular space
D0005634cellular_componentnucleus
D0005737cellular_componentcytoplasm
D0005829cellular_componentcytosol
D0005975biological_processcarbohydrate metabolic process
D0006000biological_processfructose metabolic process
D0006002biological_processfructose 6-phosphate metabolic process
D0006094biological_processgluconeogenesis
D0006111biological_processregulation of gluconeogenesis
D0016208molecular_functionAMP binding
D0016787molecular_functionhydrolase activity
D0016791molecular_functionphosphatase activity
D0030308biological_processnegative regulation of cell growth
D0030388biological_processfructose 1,6-bisphosphate metabolic process
D0031667biological_processresponse to nutrient levels
D0032869biological_processcellular response to insulin stimulus
D0042132molecular_functionfructose 1,6-bisphosphate 1-phosphatase activity
D0042578molecular_functionphosphoric ester hydrolase activity
D0042802molecular_functionidentical protein binding
D0045820biological_processnegative regulation of glycolytic process
D0046580biological_processnegative regulation of Ras protein signal transduction
D0046872molecular_functionmetal ion binding
D0048029molecular_functionmonosaccharide binding
D0061629molecular_functionRNA polymerase II-specific DNA-binding transcription factor binding
D0070062cellular_componentextracellular exosome
D0071286biological_processcellular response to magnesium ion
D0071320biological_processcellular response to cAMP
D0071466biological_processcellular response to xenobiotic stimulus
D0071475biological_processcellular hyperosmotic salinity response
D0071477biological_processcellular hypotonic salinity response
D0097403biological_processcellular response to raffinose
D1904628biological_processcellular response to phorbol 13-acetate 12-myristate
Functional Information from PDB Data
site_idAC1
Number of Residues13
Detailsbinding site for residue 93V A 401
ChainResidue
AVAL17
ALEU34
ALYS112
ATYR113
AARG140
AGLU20
AGLY21
AALA24
AGLY26
ATHR27
AGLY28
AGLU29
ALEU30
site_idAC2
Number of Residues14
Detailsbinding site for residue 93V B 401
ChainResidue
AARG25
BVAL17
BGLU20
BGLY21
BALA24
BGLY26
BTHR27
BGLY28
BGLU29
BLEU30
BTHR31
BLYS112
BTYR113
BHOH507
site_idAC3
Number of Residues15
Detailsbinding site for residue 93V C 401
ChainResidue
CGLU20
CGLY21
CALA24
CGLY26
CTHR27
CGLY28
CGLU29
CLEU30
CTHR31
CLEU34
CLYS112
CTYR113
CARG140
CMET177
DGLY26
site_idAC4
Number of Residues14
Detailsbinding site for residue 93V D 401
ChainResidue
DVAL17
DGLU20
DGLY21
DALA24
DGLY26
DTHR27
DGLY28
DGLU29
DLEU30
DTHR31
DLEU34
DLYS112
DTYR113
DMET177
Functional Information from PROSITE/UniProt
site_idPS00124
Number of Residues13
DetailsFBPASE Fructose-1-6-bisphosphatase active site. GKLrlLYEcnPMA
ChainResidueDetails
AGLY273-ALA285
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues40
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"7809062","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1FTA","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues52
DetailsBinding site: {"evidences":[{"source":"UniProtKB","id":"P00636","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues4
DetailsModified residue: {"description":"N6-succinyllysine","evidences":[{"source":"UniProtKB","id":"Q9QXD6","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues8
DetailsModified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"Q9QXD6","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues4
DetailsModified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

238582

PDB entries from 2025-07-09

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