SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

5PZQ

Human liver fructose-1,6-bisphosphatase 1 (fructose 1,6-bisphosphate 1-phosphatase, E.C.3.1.3.11) complexed with the allosteric inhibitor 2-(4-methoxyphenyl)furan-3,4-dicarboxylic acid

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Functional Information from GO Data

ChainGOidnamespacecontents
A0042132molecular_functionfructose 1,6-bisphosphate 1-phosphatase activity
A0005975biological_processcarbohydrate metabolic process
B0042132molecular_functionfructose 1,6-bisphosphate 1-phosphatase activity
B0005975biological_processcarbohydrate metabolic process
C0042132molecular_functionfructose 1,6-bisphosphate 1-phosphatase activity
C0005975biological_processcarbohydrate metabolic process
D0042132molecular_functionfructose 1,6-bisphosphate 1-phosphatase activity
D0005975biological_processcarbohydrate metabolic process
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Functional Information from PDB Data

site_idNumber of ResiduesDetails
AC113binding site for residue 93V A 401
ChainResidue
AVAL17
AGLU20
AGLY21
AALA24
AGLY26
ATHR27
AGLY28
AGLU29
ALEU30
ALEU34
ALYS112
ATYR113
AARG140
AC214binding site for residue 93V B 401
ChainResidue
AARG25
BVAL17
BGLU20
BGLY21
BALA24
BGLY26
BTHR27
BGLY28
BGLU29
BLEU30
BTHR31
BLYS112
BTYR113
BHOH507
AC315binding site for residue 93V C 401
ChainResidue
CGLU20
CGLY21
CALA24
CGLY26
CTHR27
CGLY28
CGLU29
CLEU30
CTHR31
CLEU34
CLYS112
CTYR113
CARG140
CMET177
DGLY26
AC414binding site for residue 93V D 401
ChainResidue
DVAL17
DGLU20
DGLY21
DALA24
DGLY26
DTHR27
DGLY28
DGLU29
DLEU30
DTHR31
DLEU34
DLYS112
DTYR113
DMET177
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Functional Information from PDB atom coordinates for the "HETATM" binding sites

site_idNumber of ResiduesDetails
93V_5pzq_A_401152-(4-methoxyphenyl)furan-3,4-dicarboxylic acid binding site
ChainResidueligand
AVAL1793V: 2-(4-methoxyphenyl)furan-3,4-dicarboxylic acid
AGLU20-GLY2193V: 2-(4-methoxyphenyl)furan-3,4-dicarboxylic acid
AALA2493V: 2-(4-methoxyphenyl)furan-3,4-dicarboxylic acid
AGLY26-THR3193V: 2-(4-methoxyphenyl)furan-3,4-dicarboxylic acid
ALEU3493V: 2-(4-methoxyphenyl)furan-3,4-dicarboxylic acid
ALYS112-TYR11393V: 2-(4-methoxyphenyl)furan-3,4-dicarboxylic acid
AARG14093V: 2-(4-methoxyphenyl)furan-3,4-dicarboxylic acid
AMET17793V: 2-(4-methoxyphenyl)furan-3,4-dicarboxylic acid
93V_5pzq_B_401152-(4-methoxyphenyl)furan-3,4-dicarboxylic acid binding site
ChainResidueligand
BVAL1793V: 2-(4-methoxyphenyl)furan-3,4-dicarboxylic acid
BGLU20-GLY2193V: 2-(4-methoxyphenyl)furan-3,4-dicarboxylic acid
BALA2493V: 2-(4-methoxyphenyl)furan-3,4-dicarboxylic acid
BGLY26-THR3193V: 2-(4-methoxyphenyl)furan-3,4-dicarboxylic acid
BLEU3493V: 2-(4-methoxyphenyl)furan-3,4-dicarboxylic acid
BLYS112-TYR11393V: 2-(4-methoxyphenyl)furan-3,4-dicarboxylic acid
BARG14093V: 2-(4-methoxyphenyl)furan-3,4-dicarboxylic acid
BMET17793V: 2-(4-methoxyphenyl)furan-3,4-dicarboxylic acid
93V_5pzq_C_401152-(4-methoxyphenyl)furan-3,4-dicarboxylic acid binding site
ChainResidueligand
CVAL1793V: 2-(4-methoxyphenyl)furan-3,4-dicarboxylic acid
CGLU20-GLY2193V: 2-(4-methoxyphenyl)furan-3,4-dicarboxylic acid
CALA2493V: 2-(4-methoxyphenyl)furan-3,4-dicarboxylic acid
CGLY26-THR3193V: 2-(4-methoxyphenyl)furan-3,4-dicarboxylic acid
CLEU3493V: 2-(4-methoxyphenyl)furan-3,4-dicarboxylic acid
CLYS112-TYR11393V: 2-(4-methoxyphenyl)furan-3,4-dicarboxylic acid
CARG14093V: 2-(4-methoxyphenyl)furan-3,4-dicarboxylic acid
CMET17793V: 2-(4-methoxyphenyl)furan-3,4-dicarboxylic acid
93V_5pzq_D_401152-(4-methoxyphenyl)furan-3,4-dicarboxylic acid binding site
ChainResidueligand
DVAL1793V: 2-(4-methoxyphenyl)furan-3,4-dicarboxylic acid
DGLU20-GLY2193V: 2-(4-methoxyphenyl)furan-3,4-dicarboxylic acid
DALA2493V: 2-(4-methoxyphenyl)furan-3,4-dicarboxylic acid
DGLY26-THR3193V: 2-(4-methoxyphenyl)furan-3,4-dicarboxylic acid
DLEU3493V: 2-(4-methoxyphenyl)furan-3,4-dicarboxylic acid
DLYS112-TYR11393V: 2-(4-methoxyphenyl)furan-3,4-dicarboxylic acid
DARG14093V: 2-(4-methoxyphenyl)furan-3,4-dicarboxylic acid
DMET17793V: 2-(4-methoxyphenyl)furan-3,4-dicarboxylic acid
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Functional Information from PROSITE/UniProt

site_idNumber of ResiduesDetails
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Functional Information from SwissProt/UniProt

site_idNumber of ResiduesDetails
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Catalytic Information from CSA

site_idNumber of ResiduesDetails
Protein Data Bank Japan - PDBj
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161002
entries
(2020-02-26)
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    161002
    entries available on 2020-02-26
    00:00 UTC / 09:00 JST