5PHM
PanDDA analysis group deposition -- Crystal Structure of JMJD2D in complex with N09455a
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | binding site for residue ZN A 401 |
| Chain | Residue |
| A | CYS238 |
| A | HIS244 |
| A | CYS310 |
| A | CYS312 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | binding site for residue NI A 402 |
| Chain | Residue |
| A | HIS192 |
| A | GLU194 |
| A | HIS280 |
| A | OGA403 |
| A | HOH637 |
| site_id | AC3 |
| Number of Residues | 12 |
| Details | binding site for residue OGA A 403 |
| Chain | Residue |
| A | TYR136 |
| A | HIS192 |
| A | GLU194 |
| A | SER200 |
| A | ASN202 |
| A | LYS210 |
| A | HIS280 |
| A | ALA292 |
| A | NI402 |
| A | EDO411 |
| A | HOH637 |
| A | HOH700 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | binding site for residue EDO A 404 |
| Chain | Residue |
| A | PHE31 |
| A | LYS150 |
| A | GLN151 |
| A | TRP152 |
| A | ASN153 |
| A | HIS156 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | binding site for residue EDO A 405 |
| Chain | Residue |
| A | PRO251 |
| A | THR252 |
| A | LYS255 |
| A | ARG263 |
| A | HOH623 |
| site_id | AC6 |
| Number of Residues | 8 |
| Details | binding site for residue EDO A 406 |
| Chain | Residue |
| A | GLU224 |
| A | ALA240 |
| A | PHE241 |
| A | LEU242 |
| A | TYR279 |
| A | SER308 |
| A | HOH510 |
| A | HOH563 |
| site_id | AC7 |
| Number of Residues | 8 |
| Details | binding site for residue EDO A 407 |
| Chain | Residue |
| A | ASP64 |
| A | ASN65 |
| A | ILE66 |
| A | SER67 |
| A | GLU68 |
| A | ARG82 |
| A | HOH502 |
| A | HOH503 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | binding site for residue EDO A 408 |
| Chain | Residue |
| A | PHE118 |
| A | ARG263 |
| A | ILE264 |
| A | THR265 |
| A | HOH507 |
| site_id | AC9 |
| Number of Residues | 10 |
| Details | binding site for residue EDO A 409 |
| Chain | Residue |
| A | TRP57 |
| A | LYS58 |
| A | ALA59 |
| A | ARG60 |
| A | TYR63 |
| A | TYR203 |
| A | HOH508 |
| A | HOH512 |
| A | HOH608 |
| A | HOH695 |
| site_id | AD1 |
| Number of Residues | 6 |
| Details | binding site for residue EDO A 410 |
| Chain | Residue |
| A | SER80 |
| A | THR87 |
| A | CYS168 |
| A | LYS305 |
| A | IEJ417 |
| A | HOH524 |
| site_id | AD2 |
| Number of Residues | 6 |
| Details | binding site for residue EDO A 411 |
| Chain | Residue |
| A | TYR181 |
| A | SER200 |
| A | ALA292 |
| A | ASN294 |
| A | OGA403 |
| A | HOH637 |
| site_id | AD3 |
| Number of Residues | 9 |
| Details | binding site for residue EDO A 412 |
| Chain | Residue |
| A | ASN13 |
| A | MET19 |
| A | LYS255 |
| A | GLY258 |
| A | IEJ418 |
| A | IEJ419 |
| A | HOH519 |
| A | HOH569 |
| A | HOH600 |
| site_id | AD4 |
| Number of Residues | 6 |
| Details | binding site for residue SO4 A 413 |
| Chain | Residue |
| A | ARG102 |
| A | HIS103 |
| A | ASN106 |
| A | HOH537 |
| A | HOH617 |
| A | HOH712 |
| site_id | AD5 |
| Number of Residues | 7 |
| Details | binding site for residue SO4 A 414 |
| Chain | Residue |
| A | ARG60 |
| A | GLU61 |
| A | THR62 |
| A | HOH520 |
| A | HOH544 |
| A | HOH598 |
| A | HOH609 |
| site_id | AD6 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 A 415 |
| Chain | Residue |
| A | LYS127 |
| A | ASN128 |
| A | ARG123 |
| A | LYS124 |
| site_id | AD7 |
| Number of Residues | 6 |
| Details | binding site for residue SO4 A 416 |
| Chain | Residue |
| A | PRO113 |
| A | LYS124 |
| A | ASN128 |
| A | TRP185 |
| A | LYS186 |
| A | HOH661 |
| site_id | AD8 |
| Number of Residues | 11 |
| Details | binding site for residue IEJ A 417 |
| Chain | Residue |
| A | SER80 |
| A | THR87 |
| A | GLU167 |
| A | CYS168 |
| A | PHE231 |
| A | SER234 |
| A | LYS305 |
| A | EDO410 |
| A | HOH524 |
| A | HOH622 |
| A | HOH717 |
| site_id | AD9 |
| Number of Residues | 12 |
| Details | binding site for residue IEJ A 418 |
| Chain | Residue |
| A | ASN13 |
| A | ASN17 |
| A | LYS255 |
| A | ILE259 |
| A | PRO260 |
| A | PHE261 |
| A | EDO412 |
| A | HOH519 |
| A | HOH663 |
| A | HOH702 |
| A | HOH810 |
| A | HOH872 |
| site_id | AE1 |
| Number of Residues | 11 |
| Details | binding site for residue IEJ A 419 |
| Chain | Residue |
| A | MET19 |
| A | ILE20 |
| A | LYS255 |
| A | GLU256 |
| A | EDO412 |
| A | HOH789 |
| A | HOH790 |
| A | HOH872 |
| A | HOH876 |
| A | HOH920 |
| A | HOH927 |
| site_id | AE2 |
| Number of Residues | 8 |
| Details | binding site for residue IEJ A 420 |
| Chain | Residue |
| A | LYS25 |
| A | PHE28 |
| A | ASN29 |
| A | GLU56 |
| A | TRP57 |
| A | GLN151 |
| A | HOH687 |
| A | HOH821 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 42 |
| Details | Domain: {"description":"JmjN","evidences":[{"source":"PROSITE-ProRule","id":"PRU00537","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 166 |
| Details | Domain: {"description":"JmjC","evidences":[{"source":"PROSITE-ProRule","id":"PRU00538","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"B2RXH2","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 3 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00538","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"26741168","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PDB","id":"5F5A","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5F5C","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"PolyADP-ribosyl glutamic acid","evidences":[{"source":"PubMed","id":"23102699","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
