5PHD
PanDDA analysis group deposition -- Crystal Structure of JMJD2D in complex with N09419a
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | binding site for residue ZN A 401 |
| Chain | Residue |
| A | CYS238 |
| A | HIS244 |
| A | CYS310 |
| A | CYS312 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | binding site for residue NI A 402 |
| Chain | Residue |
| A | HIS192 |
| A | GLU194 |
| A | HIS280 |
| A | OGA403 |
| A | HOH623 |
| site_id | AC3 |
| Number of Residues | 13 |
| Details | binding site for residue OGA A 403 |
| Chain | Residue |
| A | TYR136 |
| A | PHE189 |
| A | HIS192 |
| A | GLU194 |
| A | SER200 |
| A | ASN202 |
| A | LYS210 |
| A | TRP212 |
| A | HIS280 |
| A | NI402 |
| A | EDO411 |
| A | HOH623 |
| A | HOH703 |
| site_id | AC4 |
| Number of Residues | 7 |
| Details | binding site for residue EDO A 404 |
| Chain | Residue |
| A | LYS150 |
| A | GLN151 |
| A | TRP152 |
| A | ASN153 |
| A | HIS156 |
| A | HOH536 |
| A | HOH660 |
| site_id | AC5 |
| Number of Residues | 3 |
| Details | binding site for residue EDO A 405 |
| Chain | Residue |
| A | THR252 |
| A | ARG263 |
| A | HOH789 |
| site_id | AC6 |
| Number of Residues | 7 |
| Details | binding site for residue EDO A 406 |
| Chain | Residue |
| A | GLU224 |
| A | ALA240 |
| A | PHE241 |
| A | LEU242 |
| A | TYR279 |
| A | SER308 |
| A | HOH507 |
| site_id | AC7 |
| Number of Residues | 8 |
| Details | binding site for residue EDO A 407 |
| Chain | Residue |
| A | ASP64 |
| A | ASN65 |
| A | ILE66 |
| A | SER67 |
| A | GLU68 |
| A | ARG82 |
| A | 4NC418 |
| A | HOH525 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | binding site for residue EDO A 408 |
| Chain | Residue |
| A | PHE118 |
| A | ARG263 |
| A | ILE264 |
| A | THR265 |
| A | HOH529 |
| site_id | AC9 |
| Number of Residues | 10 |
| Details | binding site for residue EDO A 409 |
| Chain | Residue |
| A | TRP57 |
| A | LYS58 |
| A | ALA59 |
| A | ARG60 |
| A | TYR63 |
| A | TYR203 |
| A | HOH505 |
| A | HOH508 |
| A | HOH564 |
| A | HOH686 |
| site_id | AD1 |
| Number of Residues | 7 |
| Details | binding site for residue EDO A 410 |
| Chain | Residue |
| A | SER80 |
| A | THR87 |
| A | CYS168 |
| A | LYS305 |
| A | 4NC415 |
| A | HOH524 |
| A | HOH615 |
| site_id | AD2 |
| Number of Residues | 5 |
| Details | binding site for residue EDO A 411 |
| Chain | Residue |
| A | TYR181 |
| A | SER200 |
| A | ALA292 |
| A | ASN294 |
| A | OGA403 |
| site_id | AD3 |
| Number of Residues | 6 |
| Details | binding site for residue SO4 A 412 |
| Chain | Residue |
| A | ARG102 |
| A | HIS103 |
| A | ASN106 |
| A | HOH511 |
| A | HOH533 |
| A | HOH573 |
| site_id | AD4 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 A 413 |
| Chain | Residue |
| A | ARG123 |
| A | LYS124 |
| A | LYS127 |
| A | ASN128 |
| site_id | AD5 |
| Number of Residues | 6 |
| Details | binding site for residue SO4 A 414 |
| Chain | Residue |
| A | PRO113 |
| A | LYS124 |
| A | ASN128 |
| A | TRP185 |
| A | LYS186 |
| A | HOH631 |
| site_id | AD6 |
| Number of Residues | 14 |
| Details | binding site for residue 4NC A 415 |
| Chain | Residue |
| A | EDO410 |
| A | HOH524 |
| A | HOH615 |
| A | HOH654 |
| A | HOH723 |
| A | SER80 |
| A | VAL85 |
| A | THR87 |
| A | GLU167 |
| A | CYS168 |
| A | LEU230 |
| A | PHE231 |
| A | ILE301 |
| A | LYS305 |
| site_id | AD7 |
| Number of Residues | 10 |
| Details | binding site for residue 4NC A 416 |
| Chain | Residue |
| A | LYS25 |
| A | ASN29 |
| A | GLU56 |
| A | TRP57 |
| A | GLN151 |
| A | HOH814 |
| A | HOH830 |
| A | HOH838 |
| A | HOH886 |
| A | HOH910 |
| site_id | AD8 |
| Number of Residues | 14 |
| Details | binding site for residue 4NC A 417 |
| Chain | Residue |
| A | VAL78 |
| A | TYR89 |
| A | LYS91 |
| A | LYS305 |
| A | MET306 |
| A | GLN329 |
| A | GLU331 |
| A | ARG332 |
| A | HOH510 |
| A | HOH512 |
| A | HOH695 |
| A | HOH819 |
| A | HOH839 |
| A | HOH848 |
| site_id | AD9 |
| Number of Residues | 10 |
| Details | binding site for residue 4NC A 418 |
| Chain | Residue |
| A | ARG82 |
| A | LEU230 |
| A | VAL253 |
| A | GLU256 |
| A | ASN257 |
| A | EDO407 |
| A | HOH534 |
| A | HOH651 |
| A | HOH741 |
| A | HOH785 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 42 |
| Details | Domain: {"description":"JmjN","evidences":[{"source":"PROSITE-ProRule","id":"PRU00537","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 166 |
| Details | Domain: {"description":"JmjC","evidences":[{"source":"PROSITE-ProRule","id":"PRU00538","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"B2RXH2","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 3 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00538","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"26741168","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PDB","id":"5F5A","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5F5C","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"PolyADP-ribosyl glutamic acid","evidences":[{"source":"PubMed","id":"23102699","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
