5PH8
PanDDA analysis group deposition -- Crystal Structure of JMJD2D in complex with N09552a
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | binding site for residue ZN A 401 |
| Chain | Residue |
| A | CYS238 |
| A | HIS244 |
| A | CYS310 |
| A | CYS312 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | binding site for residue NI A 402 |
| Chain | Residue |
| A | HIS192 |
| A | GLU194 |
| A | HIS280 |
| A | OGA403 |
| A | HOH614 |
| site_id | AC3 |
| Number of Residues | 13 |
| Details | binding site for residue OGA A 403 |
| Chain | Residue |
| A | TYR136 |
| A | PHE189 |
| A | HIS192 |
| A | GLU194 |
| A | SER200 |
| A | ASN202 |
| A | LYS210 |
| A | TRP212 |
| A | HIS280 |
| A | NI402 |
| A | EDO409 |
| A | HOH614 |
| A | HOH634 |
| site_id | AC4 |
| Number of Residues | 7 |
| Details | binding site for residue EDO A 404 |
| Chain | Residue |
| A | LYS150 |
| A | GLN151 |
| A | TRP152 |
| A | ASN153 |
| A | HIS156 |
| A | HOH590 |
| A | HOH636 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | binding site for residue EDO A 405 |
| Chain | Residue |
| A | THR252 |
| A | LYS255 |
| A | ARG263 |
| A | HOH694 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | binding site for residue EDO A 406 |
| Chain | Residue |
| A | PHE118 |
| A | ILE264 |
| A | THR265 |
| A | HOH521 |
| site_id | AC7 |
| Number of Residues | 10 |
| Details | binding site for residue EDO A 407 |
| Chain | Residue |
| A | TRP57 |
| A | LYS58 |
| A | ALA59 |
| A | ARG60 |
| A | TYR63 |
| A | TYR203 |
| A | HOH510 |
| A | HOH566 |
| A | HOH599 |
| A | HOH631 |
| site_id | AC8 |
| Number of Residues | 7 |
| Details | binding site for residue EDO A 408 |
| Chain | Residue |
| A | SER80 |
| A | THR87 |
| A | CYS168 |
| A | LYS305 |
| A | 1XN415 |
| A | HOH534 |
| A | HOH730 |
| site_id | AC9 |
| Number of Residues | 7 |
| Details | binding site for residue EDO A 409 |
| Chain | Residue |
| A | TYR179 |
| A | TYR181 |
| A | SER200 |
| A | ALA292 |
| A | ASN294 |
| A | OGA403 |
| A | HOH614 |
| site_id | AD1 |
| Number of Residues | 6 |
| Details | binding site for residue SO4 A 410 |
| Chain | Residue |
| A | ARG102 |
| A | HIS103 |
| A | ASN106 |
| A | HOH506 |
| A | HOH518 |
| A | HOH642 |
| site_id | AD2 |
| Number of Residues | 7 |
| Details | binding site for residue SO4 A 411 |
| Chain | Residue |
| A | ARG60 |
| A | GLU61 |
| A | THR62 |
| A | HOH509 |
| A | HOH522 |
| A | HOH638 |
| A | HOH639 |
| site_id | AD3 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 A 412 |
| Chain | Residue |
| A | ARG123 |
| A | LYS124 |
| A | LYS127 |
| A | ASN128 |
| site_id | AD4 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 A 413 |
| Chain | Residue |
| A | PRO113 |
| A | LYS124 |
| A | ASN128 |
| A | TRP185 |
| A | LYS186 |
| site_id | AD5 |
| Number of Residues | 16 |
| Details | binding site for residue PHT A 414 |
| Chain | Residue |
| A | GLU224 |
| A | ARG228 |
| A | GLY239 |
| A | ALA240 |
| A | PHE241 |
| A | LEU242 |
| A | ARG243 |
| A | SER308 |
| A | HOH515 |
| A | HOH569 |
| A | HOH577 |
| A | HOH653 |
| A | HOH704 |
| A | HOH790 |
| A | HOH798 |
| A | HOH813 |
| site_id | AD6 |
| Number of Residues | 15 |
| Details | binding site for residue 1XN A 415 |
| Chain | Residue |
| A | SER80 |
| A | THR87 |
| A | GLU167 |
| A | CYS168 |
| A | PHE231 |
| A | PRO232 |
| A | GLY233 |
| A | SER234 |
| A | ILE301 |
| A | LYS305 |
| A | EDO408 |
| A | HOH534 |
| A | HOH693 |
| A | HOH730 |
| A | HOH886 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 42 |
| Details | Domain: {"description":"JmjN","evidences":[{"source":"PROSITE-ProRule","id":"PRU00537","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 166 |
| Details | Domain: {"description":"JmjC","evidences":[{"source":"PROSITE-ProRule","id":"PRU00538","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"B2RXH2","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 3 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00538","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"26741168","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PDB","id":"5F5A","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5F5C","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"PolyADP-ribosyl glutamic acid","evidences":[{"source":"PubMed","id":"23102699","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
