5PGX
CRYSTAL STRUCTURE OF 11BETA-HSD1 DOUBLE MUTANT (L262R, F278E) COMPLEXED WITH 2-(2-BENZYL-6-HYDROXYADAMANTAN-2-YL)-1-(3-HYDROXYAZETIDIN-1-YL)ETHAN-1-ONE
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0005496 | molecular_function | steroid binding |
A | 0005783 | cellular_component | endoplasmic reticulum |
A | 0005789 | cellular_component | endoplasmic reticulum membrane |
A | 0006706 | biological_process | steroid catabolic process |
A | 0008202 | biological_process | steroid metabolic process |
A | 0016020 | cellular_component | membrane |
A | 0016491 | molecular_function | oxidoreductase activity |
A | 0030324 | biological_process | lung development |
A | 0042803 | molecular_function | protein homodimerization activity |
A | 0043231 | cellular_component | intracellular membrane-bounded organelle |
A | 0047022 | molecular_function | 7-beta-hydroxysteroid dehydrogenase (NADP+) activity |
A | 0050661 | molecular_function | NADP binding |
A | 0070524 | molecular_function | 11-beta-hydroxysteroid dehydrogenase (NADP+) activity |
A | 0102196 | molecular_function | cortisol dehydrogenase activity |
B | 0005496 | molecular_function | steroid binding |
B | 0005783 | cellular_component | endoplasmic reticulum |
B | 0005789 | cellular_component | endoplasmic reticulum membrane |
B | 0006706 | biological_process | steroid catabolic process |
B | 0008202 | biological_process | steroid metabolic process |
B | 0016020 | cellular_component | membrane |
B | 0016491 | molecular_function | oxidoreductase activity |
B | 0030324 | biological_process | lung development |
B | 0042803 | molecular_function | protein homodimerization activity |
B | 0043231 | cellular_component | intracellular membrane-bounded organelle |
B | 0047022 | molecular_function | 7-beta-hydroxysteroid dehydrogenase (NADP+) activity |
B | 0050661 | molecular_function | NADP binding |
B | 0070524 | molecular_function | 11-beta-hydroxysteroid dehydrogenase (NADP+) activity |
B | 0102196 | molecular_function | cortisol dehydrogenase activity |
D | 0005496 | molecular_function | steroid binding |
D | 0005783 | cellular_component | endoplasmic reticulum |
D | 0005789 | cellular_component | endoplasmic reticulum membrane |
D | 0006706 | biological_process | steroid catabolic process |
D | 0008202 | biological_process | steroid metabolic process |
D | 0016020 | cellular_component | membrane |
D | 0016491 | molecular_function | oxidoreductase activity |
D | 0030324 | biological_process | lung development |
D | 0042803 | molecular_function | protein homodimerization activity |
D | 0043231 | cellular_component | intracellular membrane-bounded organelle |
D | 0047022 | molecular_function | 7-beta-hydroxysteroid dehydrogenase (NADP+) activity |
D | 0050661 | molecular_function | NADP binding |
D | 0070524 | molecular_function | 11-beta-hydroxysteroid dehydrogenase (NADP+) activity |
D | 0102196 | molecular_function | cortisol dehydrogenase activity |
E | 0005496 | molecular_function | steroid binding |
E | 0005783 | cellular_component | endoplasmic reticulum |
E | 0005789 | cellular_component | endoplasmic reticulum membrane |
E | 0006706 | biological_process | steroid catabolic process |
E | 0008202 | biological_process | steroid metabolic process |
E | 0016020 | cellular_component | membrane |
E | 0016491 | molecular_function | oxidoreductase activity |
E | 0030324 | biological_process | lung development |
E | 0042803 | molecular_function | protein homodimerization activity |
E | 0043231 | cellular_component | intracellular membrane-bounded organelle |
E | 0047022 | molecular_function | 7-beta-hydroxysteroid dehydrogenase (NADP+) activity |
E | 0050661 | molecular_function | NADP binding |
E | 0070524 | molecular_function | 11-beta-hydroxysteroid dehydrogenase (NADP+) activity |
E | 0102196 | molecular_function | cortisol dehydrogenase activity |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 25 |
Details | binding site for residue NAP A 301 |
Chain | Residue |
A | GLY41 |
A | MET93 |
A | ASN119 |
A | ILE121 |
A | VAL168 |
A | SER169 |
A | SER170 |
A | TYR183 |
A | LYS187 |
A | LEU215 |
A | GLY216 |
A | SER43 |
A | LEU217 |
A | ILE218 |
A | THR220 |
A | THR222 |
A | ALA223 |
A | 8KD302 |
A | LYS44 |
A | GLY45 |
A | ILE46 |
A | ALA65 |
A | ARG66 |
A | SER67 |
A | THR92 |
site_id | AC2 |
Number of Residues | 12 |
Details | binding site for residue 8KD A 302 |
Chain | Residue |
A | THR124 |
A | LEU126 |
A | SER170 |
A | LEU171 |
A | TYR177 |
A | VAL180 |
A | TYR183 |
A | LEU215 |
A | GLY216 |
A | LEU217 |
A | ALA226 |
A | NAP301 |
site_id | AC3 |
Number of Residues | 27 |
Details | binding site for residue NAP B 301 |
Chain | Residue |
B | GLY41 |
B | ALA42 |
B | SER43 |
B | LYS44 |
B | GLY45 |
B | ILE46 |
B | ALA65 |
B | ARG66 |
B | SER67 |
B | THR92 |
B | MET93 |
B | ASN119 |
B | ILE121 |
B | VAL168 |
B | SER169 |
B | SER170 |
B | TYR183 |
B | LYS187 |
B | LEU215 |
B | GLY216 |
B | LEU217 |
B | ILE218 |
B | THR220 |
B | THR222 |
B | ALA223 |
B | 8KD302 |
B | HOH407 |
site_id | AC4 |
Number of Residues | 13 |
Details | binding site for residue 8KD B 302 |
Chain | Residue |
B | THR124 |
B | LEU126 |
B | SER170 |
B | LEU171 |
B | TYR177 |
B | VAL180 |
B | TYR183 |
B | LEU215 |
B | GLY216 |
B | LEU217 |
B | ALA223 |
B | MET233 |
B | NAP301 |
site_id | AC5 |
Number of Residues | 30 |
Details | binding site for residue NAP D 301 |
Chain | Residue |
D | THR220 |
D | THR222 |
D | ALA223 |
D | 8KD302 |
D | HOH402 |
D | HOH403 |
D | HOH406 |
D | HOH409 |
D | GLY41 |
D | ALA42 |
D | SER43 |
D | LYS44 |
D | GLY45 |
D | ILE46 |
D | ALA65 |
D | ARG66 |
D | SER67 |
D | THR92 |
D | MET93 |
D | ASN119 |
D | ILE121 |
D | VAL168 |
D | SER169 |
D | SER170 |
D | TYR183 |
D | LYS187 |
D | LEU215 |
D | GLY216 |
D | LEU217 |
D | ILE218 |
site_id | AC6 |
Number of Residues | 11 |
Details | binding site for residue 8KD D 302 |
Chain | Residue |
D | LEU126 |
D | SER170 |
D | LEU171 |
D | TYR177 |
D | VAL180 |
D | TYR183 |
D | LEU215 |
D | GLY216 |
D | LEU217 |
D | ALA223 |
D | NAP301 |
site_id | AC7 |
Number of Residues | 26 |
Details | binding site for residue NAP E 301 |
Chain | Residue |
E | GLY41 |
E | ALA42 |
E | SER43 |
E | GLY45 |
E | ILE46 |
E | ALA65 |
E | ARG66 |
E | SER67 |
E | THR92 |
E | MET93 |
E | ASN119 |
E | ILE121 |
E | VAL168 |
E | SER169 |
E | SER170 |
E | TYR183 |
E | LYS187 |
E | LEU215 |
E | GLY216 |
E | LEU217 |
E | ILE218 |
E | THR220 |
E | THR222 |
E | ALA223 |
E | 8KD302 |
E | HOH404 |
site_id | AC8 |
Number of Residues | 11 |
Details | binding site for residue 8KD E 302 |
Chain | Residue |
E | LEU126 |
E | SER170 |
E | LEU171 |
E | TYR177 |
E | TYR183 |
E | GLY216 |
E | LEU217 |
E | ALA223 |
E | MET233 |
E | NAP301 |
E | HOH403 |
Functional Information from PROSITE/UniProt
site_id | PS00061 |
Number of Residues | 29 |
Details | ADH_SHORT Short-chain dehydrogenases/reductases family signature. SlagkvaypmVaaYSASKFALdGFFsSIR |
Chain | Residue | Details |
A | SER170-ARG198 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 1068 |
Details | TOPO_DOM: Lumenal => ECO:0000255 |
Chain | Residue | Details |
A | GLU25-LYS292 | |
B | GLU25-LYS292 | |
D | GLU25-LYS292 | |
E | GLU25-LYS292 |
site_id | SWS_FT_FI2 |
Number of Residues | 4 |
Details | ACT_SITE: Proton acceptor |
Chain | Residue | Details |
A | TYR183 | |
B | TYR183 | |
D | TYR183 | |
E | TYR183 |
site_id | SWS_FT_FI3 |
Number of Residues | 20 |
Details | BINDING: BINDING => ECO:0000269|PubMed:15513927, ECO:0000269|PubMed:17919905, ECO:0000269|PubMed:18069989, ECO:0000269|PubMed:18485702, ECO:0000269|PubMed:18553955, ECO:0000269|PubMed:19217779 |
Chain | Residue | Details |
A | GLY41 | |
B | ILE218 | |
D | GLY41 | |
D | THR92 | |
D | ASN119 | |
D | TYR183 | |
D | ILE218 | |
E | GLY41 | |
E | THR92 | |
E | ASN119 | |
E | TYR183 | |
A | THR92 | |
E | ILE218 | |
A | ASN119 | |
A | TYR183 | |
A | ILE218 | |
B | GLY41 | |
B | THR92 | |
B | ASN119 | |
B | TYR183 |
site_id | SWS_FT_FI4 |
Number of Residues | 4 |
Details | BINDING: BINDING => ECO:0000269|PubMed:15513927, ECO:0007744|PDB:1XU7, ECO:0007744|PDB:1XU9 |
Chain | Residue | Details |
A | SER170 | |
B | SER170 | |
D | SER170 | |
E | SER170 |
site_id | SWS_FT_FI5 |
Number of Residues | 8 |
Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218 |
Chain | Residue | Details |
A | ASN123 | |
A | ASN162 | |
B | ASN123 | |
B | ASN162 | |
D | ASN123 | |
D | ASN162 | |
E | ASN123 | |
E | ASN162 |
site_id | SWS_FT_FI6 |
Number of Residues | 4 |
Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
Chain | Residue | Details |
A | ASN207 | |
B | ASN207 | |
D | ASN207 | |
E | ASN207 |