5PAU

Crystal Structure of Factor VIIa in complex with N-(2-amino-1H-benzimidazol-5-yl)-2-[3-[(2-amino-2-oxoethyl)-methylsulfonylamino]phenyl]acetamide;2,2,2-trifluoroacetic acid

Functional Information from GO Data

Chain	GOid	namespace	contents
C	0004252	molecular_function	serine-type endopeptidase activity
C	0006508	biological_process	proteolysis

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	binding site for residue GOL A 301

Chain	Residue
A	GLY196
A	LYS197
A	ILE198
A	LEU201
A	GLU202
C	GLY414
C	TRP416

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site_id	AC2
Number of Residues	7
Details	binding site for residue GOL A 302

Chain	Residue
A	SER179
A	LEU180
A	HOH403
A	HOH410
A	HOH415
A	ARG173
A	CYS174

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site_id	AC3
Number of Residues	6
Details	binding site for residue CA C 501

Chain	Residue
C	GLU270
C	ASP272
C	GLU275
C	GLU280
C	HOH663
C	HOH802

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site_id	AC4
Number of Residues	1
Details	binding site for residue CL C 502

Chain	Residue
C	GLU454

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site_id	AC5
Number of Residues	2
Details	binding site for residue CL C 503

Chain	Residue
C	ARG262
C	VAL459

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site_id	AC6
Number of Residues	7
Details	binding site for residue SO4 C 504

Chain	Residue
C	MET366
C	THR367
C	ARG439
C	HOH684
C	HOH737
C	HOH745
C	HOH748

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site_id	AC7
Number of Residues	6
Details	binding site for residue SO4 C 505

Chain	Residue
C	HIS253
C	LYS401
C	GLY402
C	SER404
C	7ZJ507
C	HOH720

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site_id	AC8
Number of Residues	6
Details	binding site for residue GOL C 506

Chain	Residue
C	CYS370
C	SER374
C	HIS433
C	PHE434
C	HOH615
C	HOH670

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site_id	AC9
Number of Residues	13
Details	binding site for residue 7ZJ C 507

Chain	Residue
C	HIS253
C	ASP256
C	GLY297
C	ASP398
C	SER399
C	SER404
C	VAL422
C	SER423
C	TRP424
C	GLY425
C	GLY427
C	SO4505
C	HOH757

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Functional Information from PROSITE/UniProt

site_id	PS00134
Number of Residues	6
Details	TRYPSIN_HIS Serine proteases, trypsin family, histidine active site. VSAAHC

Chain	Residue	Details
C	VAL249-CYS254

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site_id	PS00135
Number of Residues	12
Details	TRYPSIN_SER Serine proteases, trypsin family, serine active site. DSckGDSGGPHA

Chain	Residue	Details
C	ASP398-ALA409

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site_id	PS01186
Number of Residues	16
Details	EGF_2 EGF-like domain signature 2. CrCheGYslladgvsC

Chain	Residue	Details
A	CYS172-CYS187

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	ACT_SITE: Charge relay system => ECO:0000250

Chain	Residue	Details
C	HIS253
C	ASP302
C	SER404

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site_id	SWS_FT_FI2
Number of Residues	1
Details	BINDING: BINDING => ECO:0000250

Chain	Residue	Details
C	ASP398

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site_id	SWS_FT_FI3
Number of Residues	1
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19167329, ECO:0000269|PubMed:3264725

Chain	Residue	Details
C	ASN382

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