5PAA

Crystal Structure of Factor VIIa in complex with cyclohexylmethanamine

Functional Information from GO Data

Chain	GOid	namespace	contents
C	0004252	molecular_function	serine-type endopeptidase activity
C	0006508	biological_process	proteolysis

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	binding site for residue GOL A 301

Chain	Residue
A	LYS197
A	ILE198
A	LEU201
A	GLU202
C	TRP416

---

site_id	AC2
Number of Residues	7
Details	binding site for residue GOL A 302

Chain	Residue
A	LEU180
A	HOH402
A	HOH403
A	ARG173
A	CYS174
A	TYR178
A	SER179

---

site_id	AC3
Number of Residues	6
Details	binding site for residue CA C 501

Chain	Residue
C	GLU270
C	ASP272
C	GLU275
C	GLU280
C	HOH630
C	HOH737

---

site_id	AC4
Number of Residues	1
Details	binding site for residue CL C 503

Chain	Residue
C	ARG262

---

site_id	AC5
Number of Residues	1
Details	binding site for residue CL C 504

Chain	Residue
C	ARG284

---

site_id	AC6
Number of Residues	1
Details	binding site for residue CL C 505

Chain	Residue
C	ARG262

---

site_id	AC7
Number of Residues	7
Details	binding site for residue AMC C 506

Chain	Residue
C	ASP398
C	SER399
C	CYS400
C	SER404
C	TRP424
C	GLY427
C	HOH722

---

site_id	AC8
Number of Residues	6
Details	binding site for residue SO4 C 507

Chain	Residue
C	MET366
C	THR367
C	ARG439
C	HOH618
C	HOH679
C	HOH720

---

site_id	AC9
Number of Residues	5
Details	binding site for residue SO4 C 508

Chain	Residue
C	HIS253
C	LYS401
C	GLY402
C	SER404
C	HOH730

---

site_id	AD1
Number of Residues	4
Details	binding site for residue SO4 C 509

Chain	Residue
C	GLN281
C	SER282
C	ARG283
C	HOH603

---

Functional Information from PROSITE/UniProt

site_id	PS00134
Number of Residues	6
Details	TRYPSIN_HIS Serine proteases, trypsin family, histidine active site. VSAAHC

Chain	Residue	Details
C	VAL249-CYS254

---

site_id	PS00135
Number of Residues	12
Details	TRYPSIN_SER Serine proteases, trypsin family, serine active site. DSckGDSGGPHA

Chain	Residue	Details
C	ASP398-ALA409

---

site_id	PS01186
Number of Residues	16
Details	EGF_2 EGF-like domain signature 2. CrCheGYslladgvsC

Chain	Residue	Details
A	CYS172-CYS187

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"19167329","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"3264725","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	3
Details	Active site: {"description":"Charge relay system","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---