Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000287 | molecular_function | magnesium ion binding |
| A | 0006584 | biological_process | catecholamine metabolic process |
| A | 0008171 | molecular_function | O-methyltransferase activity |
| A | 0016206 | molecular_function | catechol O-methyltransferase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 22 |
| Details | binding site for residue SAH A 301 |
| Chain | Residue |
| A | SME40 |
| A | GLU90 |
| A | ILE91 |
| A | GLY117 |
| A | ALA118 |
| A | SER119 |
| A | GLN120 |
| A | ASP141 |
| A | HIS142 |
| A | TRP143 |
| A | ARG146 |
| A | ASN41 |
| A | HOH445 |
| A | HOH484 |
| A | HOH555 |
| A | VAL42 |
| A | GLY66 |
| A | ALA67 |
| A | TYR68 |
| A | TYR71 |
| A | SER72 |
| A | MET89 |
| site_id | AC2 |
| Number of Residues | 11 |
| Details | binding site for residue 7JR A 302 |
| Chain | Residue |
| A | SME40 |
| A | ALA97 |
| A | GLN101 |
| A | ASP141 |
| A | LYS144 |
| A | ASP169 |
| A | ASN170 |
| A | GLU199 |
| A | SO4309 |
| A | MG310 |
| A | HOH442 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | binding site for residue CL A 303 |
| Chain | Residue |
| A | ASP44 |
| A | ALA45 |
| A | TYR200 |
| A | HOH578 |
| site_id | AC4 |
| Number of Residues | 9 |
| Details | binding site for residue CXS A 304 |
| Chain | Residue |
| A | LYS5 |
| A | TRP38 |
| A | GLN100 |
| A | ILE114 |
| A | MET201 |
| A | SO4308 |
| A | HOH458 |
| A | HOH459 |
| A | HOH543 |
| site_id | AC5 |
| Number of Residues | 9 |
| Details | binding site for residue CXS A 305 |
| Chain | Residue |
| A | GLU155 |
| A | TYR182 |
| A | SER188 |
| A | LYS202 |
| A | PRO215 |
| A | HOH408 |
| A | HOH437 |
| A | HOH471 |
| A | HOH478 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | binding site for residue CXS A 306 |
| Chain | Residue |
| A | ARG8 |
| A | LYS36 |
| A | GLU37 |
| A | HOH451 |
| A | HOH566 |
| A | HOH601 |
| site_id | AC7 |
| Number of Residues | 7 |
| Details | binding site for residue SO4 A 307 |
| Chain | Residue |
| A | GLY83 |
| A | ARG85 |
| A | LYS111 |
| A | LYS128 |
| A | HOH413 |
| A | HOH425 |
| A | HOH564 |
| site_id | AC8 |
| Number of Residues | 8 |
| Details | binding site for residue SO4 A 308 |
| Chain | Residue |
| A | GLU37 |
| A | TRP38 |
| A | LEU115 |
| A | ASN116 |
| A | CXS304 |
| A | HOH414 |
| A | HOH435 |
| A | HOH467 |
| site_id | AC9 |
| Number of Residues | 6 |
| Details | binding site for residue SO4 A 309 |
| Chain | Residue |
| A | TRP143 |
| A | LYS144 |
| A | 7JR302 |
| A | HOH401 |
| A | HOH402 |
| A | HOH585 |
| site_id | AD1 |
| Number of Residues | 5 |
| Details | binding site for residue MG A 310 |
| Chain | Residue |
| A | ASP141 |
| A | ASP169 |
| A | ASN170 |
| A | 7JR302 |
| A | HOH442 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU01019","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"12237326","evidenceCode":"ECO:0000269"}]} |
| site_id | SWS_FT_FI2 |
| Number of Residues | 3 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU01019","evidenceCode":"ECO:0000255"}]} |
| site_id | SWS_FT_FI3 |
| Number of Residues | 7 |
| Details | Binding site: {} |
Catalytic Information from CSA
| site_id | MCSA1 |
| Number of Residues | 5 |
| Details | M-CSA 915 |
| Chain | Residue | Details |
| A | ASP145 | metal ligand |
| A | LEU148 | proton shuttle (general acid/base) |
| A | VAL173 | metal ligand |
| A | PRO174 | metal ligand |
| A | VAL203 | electrostatic stabiliser |
