Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004067 | molecular_function | asparaginase activity |
| A | 0006520 | biological_process | amino acid metabolic process |
| A | 0016787 | molecular_function | hydrolase activity |
| B | 0004067 | molecular_function | asparaginase activity |
| B | 0006520 | biological_process | amino acid metabolic process |
| B | 0016787 | molecular_function | hydrolase activity |
| C | 0004067 | molecular_function | asparaginase activity |
| C | 0006520 | biological_process | amino acid metabolic process |
| C | 0016787 | molecular_function | hydrolase activity |
| D | 0004067 | molecular_function | asparaginase activity |
| D | 0006520 | biological_process | amino acid metabolic process |
| D | 0016787 | molecular_function | hydrolase activity |
| E | 0004067 | molecular_function | asparaginase activity |
| E | 0006520 | biological_process | amino acid metabolic process |
| E | 0016787 | molecular_function | hydrolase activity |
| F | 0004067 | molecular_function | asparaginase activity |
| F | 0006520 | biological_process | amino acid metabolic process |
| F | 0016787 | molecular_function | hydrolase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 9 |
| Details | binding site for residue PO4 A 401 |
| Chain | Residue |
| A | GLY10 |
| A | THR11 |
| A | ASP53 |
| A | SER54 |
| A | GLY84 |
| A | THR85 |
| A | ASP86 |
| A | HOH505 |
| A | HOH524 |
| site_id | AC2 |
| Number of Residues | 9 |
| Details | binding site for residue EDO A 402 |
| Chain | Residue |
| A | ASN169 |
| A | ALA264 |
| A | LEU265 |
| A | TYR266 |
| A | GLY267 |
| A | GLY268 |
| A | MET291 |
| A | LYS293 |
| A | HOH531 |
| site_id | AC3 |
| Number of Residues | 11 |
| Details | binding site for residue PO4 B 401 |
| Chain | Residue |
| A | TYR274 |
| B | GLY10 |
| B | THR11 |
| B | ASP53 |
| B | SER54 |
| B | GLY84 |
| B | THR85 |
| B | ASP86 |
| B | HOH507 |
| B | HOH510 |
| B | HOH516 |
| site_id | AC4 |
| Number of Residues | 9 |
| Details | binding site for residue EDO B 402 |
| Chain | Residue |
| B | ASN169 |
| B | ALA264 |
| B | LEU265 |
| B | TYR266 |
| B | GLY267 |
| B | GLY268 |
| B | MET291 |
| B | LYS293 |
| B | HOH526 |
| site_id | AC5 |
| Number of Residues | 7 |
| Details | binding site for residue EDO B 403 |
| Chain | Residue |
| B | GLY7 |
| B | ALA13 |
| B | LEU25 |
| B | ASP48 |
| B | LEU50 |
| B | ASN51 |
| B | HOH511 |
| site_id | AC6 |
| Number of Residues | 8 |
| Details | binding site for residue PG4 B 404 |
| Chain | Residue |
| B | ASP28 |
| B | GLU45 |
| B | THR46 |
| B | ASP48 |
| D | ILE49 |
| D | LEU50 |
| D | ASN51 |
| D | EDO402 |
| site_id | AC7 |
| Number of Residues | 7 |
| Details | binding site for residue PO4 C 401 |
| Chain | Residue |
| C | GLY10 |
| C | THR11 |
| C | SER54 |
| C | GLY84 |
| C | THR85 |
| C | ASP86 |
| D | TYR274 |
| site_id | AC8 |
| Number of Residues | 9 |
| Details | binding site for residue PO4 D 401 |
| Chain | Residue |
| C | TYR274 |
| D | GLY10 |
| D | THR11 |
| D | ASP53 |
| D | SER54 |
| D | GLY84 |
| D | THR85 |
| D | ASP86 |
| D | HOH504 |
| site_id | AC9 |
| Number of Residues | 10 |
| Details | binding site for residue EDO D 402 |
| Chain | Residue |
| B | PG4404 |
| D | GLY9 |
| D | ALA13 |
| D | ALA24 |
| D | LEU25 |
| D | ASP48 |
| D | LEU50 |
| D | ASN51 |
| D | HOH502 |
| D | HOH510 |
| site_id | AD1 |
| Number of Residues | 9 |
| Details | binding site for residue EDO D 403 |
| Chain | Residue |
| D | ASN169 |
| D | ALA264 |
| D | LEU265 |
| D | TYR266 |
| D | GLY267 |
| D | GLY268 |
| D | MET291 |
| D | LYS293 |
| D | HOH528 |
| site_id | AD2 |
| Number of Residues | 9 |
| Details | binding site for residue PO4 E 401 |
| Chain | Residue |
| E | GLY10 |
| E | THR11 |
| E | SER54 |
| E | GLY84 |
| E | THR85 |
| E | ASP86 |
| E | HOH504 |
| E | HOH514 |
| F | TYR274 |
| site_id | AD3 |
| Number of Residues | 7 |
| Details | binding site for residue PO4 F 401 |
| Chain | Residue |
| F | THR11 |
| F | SER54 |
| F | GLY84 |
| F | THR85 |
| F | ASP86 |
| E | TYR274 |
| F | GLY10 |
| site_id | AD4 |
| Number of Residues | 8 |
| Details | binding site for residue EDO F 402 |
| Chain | Residue |
| F | ASN169 |
| F | THR262 |
| F | ALA264 |
| F | LEU265 |
| F | TYR266 |
| F | GLY267 |
| F | GLY268 |
| F | LYS293 |
Functional Information from PROSITE/UniProt
| site_id | PS00144 |
| Number of Residues | 9 |
| Details | ASN_GLN_ASE_1 Asparaginase / glutaminase active site signature 1. VlGTGGTIA |
| Chain | Residue | Details |
| A | VAL5-ALA13 | |
| site_id | PS00917 |
| Number of Residues | 11 |
| Details | ASN_GLN_ASE_2 Asparaginase / glutaminase active site signature 2. GiVitHGTDTL |
| Chain | Residue | Details |
| A | GLY78-LEU88 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1914 |
| Details | Domain: {"description":"Asparaginase/glutaminase","evidences":[{"source":"PROSITE-ProRule","id":"PRU01068","evidenceCode":"ECO:0000255"}]} |
| site_id | SWS_FT_FI2 |
| Number of Residues | 6 |
| Details | Active site: {"description":"Nucleophile; O-isoaspartyl threonine intermediate","evidences":[{"source":"UniProtKB","id":"Q8TZE8","evidenceCode":"ECO:0000250"}]} |
| site_id | SWS_FT_FI3 |
| Number of Residues | 24 |
| Details | Active site: {"description":"Charge relay system","evidences":[{"source":"UniProtKB","id":"Q8TZE8","evidenceCode":"ECO:0000250"}]} |
| site_id | SWS_FT_FI4 |
| Number of Residues | 30 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"Q8TZE8","evidenceCode":"ECO:0000250"}]} |
