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5ONI

LOW-SALT STRUCTURE OF PROTEIN KINASE CK2 CATALYTIC SUBUNIT (ISOFORM CK2ALPHA) IN COMPLEX WITH THE INDENOINDOLE-TYPE INHIBITOR 4P

Functional Information from GO Data
ChainGOidnamespacecontents
A0004672molecular_functionprotein kinase activity
A0004674molecular_functionprotein serine/threonine kinase activity
A0004676molecular_function3-phosphoinositide-dependent protein kinase activity
A0004677molecular_functionDNA-dependent protein kinase activity
A0004679molecular_functionAMP-activated protein kinase activity
A0004694molecular_functioneukaryotic translation initiation factor 2alpha kinase activity
A0004711molecular_functionribosomal protein S6 kinase activity
A0005515molecular_functionprotein binding
A0005524molecular_functionATP binding
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005829cellular_componentcytosol
A0005886cellular_componentplasma membrane
A0005956cellular_componentprotein kinase CK2 complex
A0006302biological_processdouble-strand break repair
A0006338biological_processchromatin remodeling
A0006468biological_processprotein phosphorylation
A0006915biological_processapoptotic process
A0006974biological_processDNA damage response
A0007165biological_processsignal transduction
A0008284biological_processpositive regulation of cell population proliferation
A0016055biological_processWnt signaling pathway
A0016301molecular_functionkinase activity
A0016605cellular_componentPML body
A0017148biological_processnegative regulation of translation
A0018105biological_processpeptidyl-serine phosphorylation
A0018107biological_processpeptidyl-threonine phosphorylation
A0030177biological_processpositive regulation of Wnt signaling pathway
A0030307biological_processpositive regulation of cell growth
A0031519cellular_componentPcG protein complex
A0032435biological_processnegative regulation of proteasomal ubiquitin-dependent protein catabolic process
A0035175molecular_functionhistone H3S10 kinase activity
A0035402molecular_functionhistone H3T11 kinase activity
A0035403molecular_functionhistone H3T6 kinase activity
A0035979molecular_functionhistone H2AXS139 kinase activity
A0042802molecular_functionidentical protein binding
A0044022molecular_functionhistone H3S28 kinase activity
A0044023molecular_functionhistone H4S1 kinase activity
A0044024molecular_functionhistone H2AS1 kinase activity
A0044025molecular_functionhistone H2BS14 kinase activity
A0045732biological_processpositive regulation of protein catabolic process
A0048511biological_processrhythmic process
A0050821biological_processprotein stabilization
A0051726biological_processregulation of cell cycle
A0051879molecular_functionHsp90 protein binding
A0061077biological_processchaperone-mediated protein folding
A0070822cellular_componentSin3-type complex
A0072354molecular_functionhistone H3T3 kinase activity
A0072371molecular_functionhistone H2AS121 kinase activity
A0072518molecular_functionRho-dependent protein serine/threonine kinase activity
A0075342biological_processsymbiont-mediated disruption of host cell PML body
A0106310molecular_functionprotein serine kinase activity
A0140823molecular_functionhistone H2BS36 kinase activity
A0140855molecular_functionhistone H3S57 kinase activity
A0140857molecular_functionhistone H3T45 kinase activity
A1905337biological_processpositive regulation of aggrephagy
A1905818biological_processregulation of chromosome separation
A1990244molecular_functionhistone H2AT120 kinase activity
A2000042biological_processnegative regulation of double-strand break repair via homologous recombination
A2000117biological_processnegative regulation of cysteine-type endopeptidase activity
A2001234biological_processnegative regulation of apoptotic signaling pathway
B0004672molecular_functionprotein kinase activity
B0004674molecular_functionprotein serine/threonine kinase activity
B0004676molecular_function3-phosphoinositide-dependent protein kinase activity
B0004677molecular_functionDNA-dependent protein kinase activity
B0004679molecular_functionAMP-activated protein kinase activity
B0004694molecular_functioneukaryotic translation initiation factor 2alpha kinase activity
B0004711molecular_functionribosomal protein S6 kinase activity
B0005515molecular_functionprotein binding
B0005524molecular_functionATP binding
B0005634cellular_componentnucleus
B0005654cellular_componentnucleoplasm
B0005829cellular_componentcytosol
B0005886cellular_componentplasma membrane
B0005956cellular_componentprotein kinase CK2 complex
B0006302biological_processdouble-strand break repair
B0006338biological_processchromatin remodeling
B0006468biological_processprotein phosphorylation
B0006915biological_processapoptotic process
B0006974biological_processDNA damage response
B0007165biological_processsignal transduction
B0008284biological_processpositive regulation of cell population proliferation
B0016055biological_processWnt signaling pathway
B0016301molecular_functionkinase activity
B0016605cellular_componentPML body
B0017148biological_processnegative regulation of translation
B0018105biological_processpeptidyl-serine phosphorylation
B0018107biological_processpeptidyl-threonine phosphorylation
B0030177biological_processpositive regulation of Wnt signaling pathway
B0030307biological_processpositive regulation of cell growth
B0031519cellular_componentPcG protein complex
B0032435biological_processnegative regulation of proteasomal ubiquitin-dependent protein catabolic process
B0035175molecular_functionhistone H3S10 kinase activity
B0035402molecular_functionhistone H3T11 kinase activity
B0035403molecular_functionhistone H3T6 kinase activity
B0035979molecular_functionhistone H2AXS139 kinase activity
B0042802molecular_functionidentical protein binding
B0044022molecular_functionhistone H3S28 kinase activity
B0044023molecular_functionhistone H4S1 kinase activity
B0044024molecular_functionhistone H2AS1 kinase activity
B0044025molecular_functionhistone H2BS14 kinase activity
B0045732biological_processpositive regulation of protein catabolic process
B0048511biological_processrhythmic process
B0050821biological_processprotein stabilization
B0051726biological_processregulation of cell cycle
B0051879molecular_functionHsp90 protein binding
B0061077biological_processchaperone-mediated protein folding
B0070822cellular_componentSin3-type complex
B0072354molecular_functionhistone H3T3 kinase activity
B0072371molecular_functionhistone H2AS121 kinase activity
B0072518molecular_functionRho-dependent protein serine/threonine kinase activity
B0075342biological_processsymbiont-mediated disruption of host cell PML body
B0106310molecular_functionprotein serine kinase activity
B0140823molecular_functionhistone H2BS36 kinase activity
B0140855molecular_functionhistone H3S57 kinase activity
B0140857molecular_functionhistone H3T45 kinase activity
B1905337biological_processpositive regulation of aggrephagy
B1905818biological_processregulation of chromosome separation
B1990244molecular_functionhistone H2AT120 kinase activity
B2000042biological_processnegative regulation of double-strand break repair via homologous recombination
B2000117biological_processnegative regulation of cysteine-type endopeptidase activity
B2001234biological_processnegative regulation of apoptotic signaling pathway
Functional Information from PDB Data
site_idAC1
Number of Residues11
Detailsbinding site for residue 9YE A 401
ChainResidue
AGLY48
AASP175
AHOH512
AVAL66
ALYS68
AILE95
APHE113
AGLU114
AVAL116
AMET163
AILE174

site_idAC2
Number of Residues7
Detailsbinding site for residue SO4 A 402
ChainResidue
ALYS74
ALYS77
AARG80
AARG155
AASN189
AVAL192
AHOH545

site_idAC3
Number of Residues4
Detailsbinding site for residue SO4 A 403
ChainResidue
AARG191
ALYS198
AASN238
AHOH533

site_idAC4
Number of Residues3
Detailsbinding site for residue SO4 A 404
ChainResidue
ATRP33
ALYS102
AHOH572

site_idAC5
Number of Residues3
Detailsbinding site for residue SO4 A 405
ChainResidue
ALYS102
AARG107
BLYS76

site_idAC6
Number of Residues3
Detailsbinding site for residue SO4 A 406
ChainResidue
AHIS276
ASER277
ALYS279

site_idAC7
Number of Residues2
Detailsbinding site for residue NA A 407
ChainResidue
AASN161
AASP175

site_idAC8
Number of Residues8
Detailsbinding site for residue 9YE B 401
ChainResidue
BLYS68
BPHE113
BVAL116
BASN118
BMET163
BILE174
BASP175
BHOH514

site_idAC9
Number of Residues5
Detailsbinding site for residue SO4 B 402
ChainResidue
BLYS77
BARG80
BARG155
BASN189
BHOH508

site_idAD1
Number of Residues3
Detailsbinding site for residue SO4 B 403
ChainResidue
BARG191
BLYS198
BASN238

site_idAD2
Number of Residues3
Detailsbinding site for residue SO4 B 404
ChainResidue
BLYS102
BARG107
BSO4405

site_idAD3
Number of Residues3
Detailsbinding site for residue SO4 B 405
ChainResidue
BTRP33
BLYS102
BSO4404

site_idAD4
Number of Residues4
Detailsbinding site for residue SO4 B 406
ChainResidue
BARG275
BHIS276
BSER277
BLYS279

site_idAD5
Number of Residues1
Detailsbinding site for residue CL B 407
ChainResidue
BARG280

site_idAD6
Number of Residues2
Detailsbinding site for residue CL B 408
ChainResidue
BLYS229
BARG244

site_idAD7
Number of Residues4
Detailsbinding site for residue BU1 B 409
ChainResidue
BARG21
BGLN36
BLEU41
BHOH575

Functional Information from PROSITE/UniProt
site_idPS00107
Number of Residues24
DetailsPROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGRGKYSEVFeAinitnnek..........VVVK
ChainResidueDetails
ALEU45-LYS68

site_idPS00108
Number of Residues13
DetailsPROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. ImHrDVKphNVMI
ChainResidueDetails
AILE152-ILE164

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsACT_SITE: Proton acceptor
ChainResidueDetails
AASP156
BASP156

site_idSWS_FT_FI2
Number of Residues4
DetailsBINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00159
ChainResidueDetails
ALEU45
ALYS68
BLEU45
BLYS68

site_idSWS_FT_FI3
Number of Residues4
DetailsMOD_RES: Phosphothreonine; by CDK1 => ECO:0000269|PubMed:7592773
ChainResidueDetails
ATHR344
ATHR360
BTHR344
BTHR360

site_idSWS_FT_FI4
Number of Residues2
DetailsMOD_RES: Phosphoserine; by CDK1 => ECO:0000269|PubMed:7592773
ChainResidueDetails
ASER362
BSER362

site_idSWS_FT_FI5
Number of Residues2
DetailsMOD_RES: Phosphoserine; by CDK1 => ECO:0000269|PubMed:7592773, ECO:0007744|PubMed:18691976
ChainResidueDetails
ASER370
BSER370

227344

PDB entries from 2024-11-13

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