5ON8
Crystal structure of NikA in complex with reduced Fe-L2 (N-(2-hydroxy-3-methoxybenzyl)-N'-(2-thiomethylbenzyl)- N,N'-ethylenediamine diacetic acid)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005515 | molecular_function | protein binding |
| A | 0015675 | biological_process | nickel cation transport |
| A | 0015833 | biological_process | peptide transport |
| A | 0016020 | cellular_component | membrane |
| A | 0016151 | molecular_function | nickel cation binding |
| A | 0020037 | molecular_function | heme binding |
| A | 0030288 | cellular_component | outer membrane-bounded periplasmic space |
| A | 0042597 | cellular_component | periplasmic space |
| A | 0043190 | cellular_component | ATP-binding cassette (ABC) transporter complex |
| A | 0046914 | molecular_function | transition metal ion binding |
| A | 0050919 | biological_process | negative chemotaxis |
| A | 0051540 | molecular_function | metal cluster binding |
| A | 0055052 | cellular_component | ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing |
| A | 0055085 | biological_process | transmembrane transport |
| A | 0098716 | biological_process | nickel cation import across plasma membrane |
| A | 1904680 | molecular_function | peptide transmembrane transporter activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0015675 | biological_process | nickel cation transport |
| B | 0015833 | biological_process | peptide transport |
| B | 0016020 | cellular_component | membrane |
| B | 0016151 | molecular_function | nickel cation binding |
| B | 0020037 | molecular_function | heme binding |
| B | 0030288 | cellular_component | outer membrane-bounded periplasmic space |
| B | 0042597 | cellular_component | periplasmic space |
| B | 0043190 | cellular_component | ATP-binding cassette (ABC) transporter complex |
| B | 0046914 | molecular_function | transition metal ion binding |
| B | 0050919 | biological_process | negative chemotaxis |
| B | 0051540 | molecular_function | metal cluster binding |
| B | 0055052 | cellular_component | ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing |
| B | 0055085 | biological_process | transmembrane transport |
| B | 0098716 | biological_process | nickel cation import across plasma membrane |
| B | 1904680 | molecular_function | peptide transmembrane transporter activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 1 |
| Details | binding site for residue FE A 601 |
| Chain | Residue |
| A | 9YH602 |
| site_id | AC2 |
| Number of Residues | 10 |
| Details | binding site for residue 9YH A 602 |
| Chain | Residue |
| A | GOL618 |
| A | HOH814 |
| A | TYR22 |
| A | THR23 |
| A | MET27 |
| A | ARG97 |
| A | TRP100 |
| A | ARG137 |
| A | TRP398 |
| A | FE601 |
| site_id | AC3 |
| Number of Residues | 7 |
| Details | binding site for residue ACT A 603 |
| Chain | Residue |
| A | LEU167 |
| A | GLN168 |
| A | HOH710 |
| B | VAL207 |
| B | ALA208 |
| B | THR211 |
| B | ASP213 |
| site_id | AC4 |
| Number of Residues | 10 |
| Details | binding site for residue GOL A 604 |
| Chain | Residue |
| A | VAL273 |
| A | ASN274 |
| A | LYS275 |
| A | LYS276 |
| A | ASP291 |
| A | SER308 |
| A | GLN309 |
| A | TYR310 |
| A | HOH702 |
| A | HOH721 |
| site_id | AC5 |
| Number of Residues | 3 |
| Details | binding site for residue ACT A 605 |
| Chain | Residue |
| A | SER53 |
| A | TRP54 |
| A | HOH1034 |
| site_id | AC6 |
| Number of Residues | 8 |
| Details | binding site for residue GOL A 606 |
| Chain | Residue |
| A | ASN270 |
| A | LYS306 |
| A | SER308 |
| A | HIS459 |
| A | TYR464 |
| A | HOH729 |
| A | HOH754 |
| A | HOH791 |
| site_id | AC7 |
| Number of Residues | 3 |
| Details | binding site for residue ACT A 607 |
| Chain | Residue |
| A | LYS335 |
| A | HOH883 |
| B | ARG341 |
| site_id | AC8 |
| Number of Residues | 3 |
| Details | binding site for residue ACT A 608 |
| Chain | Residue |
| A | LEU430 |
| A | GLU434 |
| A | GLU437 |
| site_id | AC9 |
| Number of Residues | 5 |
| Details | binding site for residue ACT A 609 |
| Chain | Residue |
| A | GLN361 |
| A | SER372 |
| A | LEU373 |
| A | HOH943 |
| B | HOH1114 |
| site_id | AD1 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 A 610 |
| Chain | Residue |
| A | ALA440 |
| A | THR441 |
| A | HIS442 |
| A | ASP443 |
| A | HOH723 |
| site_id | AD2 |
| Number of Residues | 6 |
| Details | binding site for residue ACT A 611 |
| Chain | Residue |
| A | PHE147 |
| A | LYS148 |
| A | ASN149 |
| A | LYS157 |
| A | HOH816 |
| A | HOH933 |
| site_id | AD3 |
| Number of Residues | 2 |
| Details | binding site for residue CL A 612 |
| Chain | Residue |
| A | LEU430 |
| A | LYS433 |
| site_id | AD4 |
| Number of Residues | 5 |
| Details | binding site for residue CL A 613 |
| Chain | Residue |
| A | GLN234 |
| A | ARG386 |
| A | SER415 |
| A | HOH974 |
| B | LYS306 |
| site_id | AD5 |
| Number of Residues | 5 |
| Details | binding site for residue ACT A 614 |
| Chain | Residue |
| A | ARG68 |
| A | ASP69 |
| A | ASP70 |
| A | HOH761 |
| A | HOH985 |
| site_id | AD6 |
| Number of Residues | 3 |
| Details | binding site for residue ACT A 615 |
| Chain | Residue |
| A | ASN261 |
| A | LEU263 |
| A | HOH982 |
| site_id | AD7 |
| Number of Residues | 5 |
| Details | binding site for residue ACT A 616 |
| Chain | Residue |
| A | ASN235 |
| A | ALA237 |
| A | PHE419 |
| A | GLN423 |
| A | HOH758 |
| site_id | AD8 |
| Number of Residues | 8 |
| Details | binding site for residue SO4 A 617 |
| Chain | Residue |
| A | GLU343 |
| A | ARG384 |
| A | HOH709 |
| A | HOH715 |
| A | HOH771 |
| A | HOH787 |
| B | LEU430 |
| B | ARG457 |
| site_id | AD9 |
| Number of Residues | 7 |
| Details | binding site for residue GOL A 618 |
| Chain | Residue |
| A | ASN220 |
| A | GLU247 |
| A | THR490 |
| A | 9YH602 |
| A | GOL619 |
| A | HOH748 |
| A | HOH936 |
| site_id | AE1 |
| Number of Residues | 8 |
| Details | binding site for residue GOL A 619 |
| Chain | Residue |
| A | GLY222 |
| A | LEU223 |
| A | GOL618 |
| A | HOH760 |
| A | HOH864 |
| A | PRO11 |
| A | GLY219 |
| A | ASN220 |
| site_id | AE2 |
| Number of Residues | 8 |
| Details | binding site for residue GOL A 620 |
| Chain | Residue |
| A | GLU102 |
| A | ASN105 |
| A | LYS123 |
| A | ASP227 |
| A | THR228 |
| A | ARG231 |
| A | HOH712 |
| A | HOH1006 |
| site_id | AE3 |
| Number of Residues | 3 |
| Details | binding site for residue CL A 621 |
| Chain | Residue |
| A | THR23 |
| A | GLN26 |
| A | HOH1185 |
| site_id | AE4 |
| Number of Residues | 1 |
| Details | binding site for residue FE B 601 |
| Chain | Residue |
| B | 9YH602 |
| site_id | AE5 |
| Number of Residues | 12 |
| Details | binding site for residue 9YH B 602 |
| Chain | Residue |
| B | TYR22 |
| B | MET27 |
| B | ARG97 |
| B | TRP100 |
| B | ARG137 |
| B | TRP398 |
| B | HIS416 |
| B | THR490 |
| B | FE601 |
| B | HOH716 |
| B | HOH758 |
| B | HOH780 |
| site_id | AE6 |
| Number of Residues | 9 |
| Details | binding site for residue GOL B 603 |
| Chain | Residue |
| A | ASP43 |
| A | GLY44 |
| A | PRO299 |
| A | HOH1027 |
| B | ASN482 |
| B | ILE483 |
| B | PRO484 |
| B | TYR485 |
| B | HOH712 |
| site_id | AE7 |
| Number of Residues | 2 |
| Details | binding site for residue CL B 604 |
| Chain | Residue |
| B | ARG365 |
| B | HOH706 |
| site_id | AE8 |
| Number of Residues | 9 |
| Details | binding site for residue GOL B 605 |
| Chain | Residue |
| B | TRP10 |
| B | PRO11 |
| B | GLY219 |
| B | ASN220 |
| B | GLY222 |
| B | LEU223 |
| B | GOL606 |
| B | HOH760 |
| B | HOH790 |
| site_id | AE9 |
| Number of Residues | 8 |
| Details | binding site for residue GOL B 606 |
| Chain | Residue |
| B | ASN220 |
| B | GLU247 |
| B | ARG396 |
| B | MET472 |
| B | THR490 |
| B | GOL605 |
| B | HOH763 |
| B | HOH1027 |
| site_id | AF1 |
| Number of Residues | 5 |
| Details | binding site for residue ACT B 607 |
| Chain | Residue |
| B | ASN183 |
| B | LYS433 |
| B | HOH771 |
| B | HOH977 |
| B | HOH1008 |
Functional Information from PROSITE/UniProt
| site_id | PS01040 |
| Number of Residues | 23 |
| Details | SBP_BACTERIAL_5 Bacterial extracellular solute-binding proteins, family 5 signature. AkswthseDgkTWtFtLRDDVKF |
| Chain | Residue | Details |
| A | ALA51-PHE73 |
