5ON0
Crystal structure of NikA in complex with Fe-L2 (N-(2-hydroxy-3methoxybenzyl)-N-N'-ethylenediaminediacetic acid)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005515 | molecular_function | protein binding |
| A | 0015675 | biological_process | nickel cation transport |
| A | 0015833 | biological_process | peptide transport |
| A | 0016020 | cellular_component | membrane |
| A | 0016151 | molecular_function | nickel cation binding |
| A | 0020037 | molecular_function | heme binding |
| A | 0030288 | cellular_component | outer membrane-bounded periplasmic space |
| A | 0042597 | cellular_component | periplasmic space |
| A | 0043190 | cellular_component | ATP-binding cassette (ABC) transporter complex |
| A | 0046914 | molecular_function | transition metal ion binding |
| A | 0050919 | biological_process | negative chemotaxis |
| A | 0051540 | molecular_function | metal cluster binding |
| A | 0055052 | cellular_component | ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing |
| A | 0055085 | biological_process | transmembrane transport |
| A | 0098716 | biological_process | nickel cation import across plasma membrane |
| A | 1904680 | molecular_function | peptide transmembrane transporter activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0015675 | biological_process | nickel cation transport |
| B | 0015833 | biological_process | peptide transport |
| B | 0016020 | cellular_component | membrane |
| B | 0016151 | molecular_function | nickel cation binding |
| B | 0020037 | molecular_function | heme binding |
| B | 0030288 | cellular_component | outer membrane-bounded periplasmic space |
| B | 0042597 | cellular_component | periplasmic space |
| B | 0043190 | cellular_component | ATP-binding cassette (ABC) transporter complex |
| B | 0046914 | molecular_function | transition metal ion binding |
| B | 0050919 | biological_process | negative chemotaxis |
| B | 0051540 | molecular_function | metal cluster binding |
| B | 0055052 | cellular_component | ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing |
| B | 0055085 | biological_process | transmembrane transport |
| B | 0098716 | biological_process | nickel cation import across plasma membrane |
| B | 1904680 | molecular_function | peptide transmembrane transporter activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 2 |
| Details | binding site for residue FE A 601 |
| Chain | Residue |
| A | 9YH602 |
| A | HOH1060 |
| site_id | AC2 |
| Number of Residues | 12 |
| Details | binding site for residue 9YH A 602 |
| Chain | Residue |
| A | FE601 |
| A | GOL608 |
| A | HOH702 |
| A | HOH803 |
| A | HOH832 |
| A | TYR22 |
| A | MET27 |
| A | ARG97 |
| A | TRP100 |
| A | ARG137 |
| A | TRP398 |
| A | HIS416 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | binding site for residue ACT A 603 |
| Chain | Residue |
| A | ARG68 |
| A | ASP69 |
| A | ASP70 |
| A | HOH704 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | binding site for residue ACT A 604 |
| Chain | Residue |
| A | ASN261 |
| A | GLU262 |
| A | LEU263 |
| A | HOH1033 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | binding site for residue ACT A 605 |
| Chain | Residue |
| A | ASN235 |
| A | ALA237 |
| A | GLN423 |
| A | HOH715 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 A 606 |
| Chain | Residue |
| A | GLU343 |
| A | ARG384 |
| A | ARG389 |
| A | HOH816 |
| B | ARG457 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | binding site for residue GOL A 607 |
| Chain | Residue |
| A | TYR485 |
| A | ALA486 |
| A | HOH778 |
| A | HOH979 |
| site_id | AC8 |
| Number of Residues | 7 |
| Details | binding site for residue GOL A 608 |
| Chain | Residue |
| A | ASN220 |
| A | GLU247 |
| A | 9YH602 |
| A | GOL609 |
| A | HOH722 |
| A | HOH766 |
| A | HOH926 |
| site_id | AC9 |
| Number of Residues | 6 |
| Details | binding site for residue GOL A 609 |
| Chain | Residue |
| A | TRP10 |
| A | GLY219 |
| A | ASN220 |
| A | GLY222 |
| A | LEU223 |
| A | GOL608 |
| site_id | AD1 |
| Number of Residues | 9 |
| Details | binding site for residue GOL A 610 |
| Chain | Residue |
| A | GLU102 |
| A | ASN105 |
| A | LYS123 |
| A | ASP227 |
| A | THR228 |
| A | HOH932 |
| A | HOH964 |
| A | HOH996 |
| A | HOH1040 |
| site_id | AD2 |
| Number of Residues | 2 |
| Details | binding site for residue CL A 611 |
| Chain | Residue |
| A | THR23 |
| A | GLN26 |
| site_id | AD3 |
| Number of Residues | 5 |
| Details | binding site for residue GOL A 612 |
| Chain | Residue |
| A | PHE209 |
| A | GLY212 |
| A | ILE214 |
| A | TYR238 |
| A | LYS477 |
| site_id | AD4 |
| Number of Residues | 9 |
| Details | binding site for residue GOL A 613 |
| Chain | Residue |
| A | GLU82 |
| A | ALA85 |
| A | GLU86 |
| A | LYS111 |
| A | ALA112 |
| A | GLN366 |
| A | HOH752 |
| A | HOH855 |
| A | HOH870 |
| site_id | AD5 |
| Number of Residues | 7 |
| Details | binding site for residue GOL A 614 |
| Chain | Residue |
| A | ASN270 |
| A | LYS306 |
| A | SER308 |
| A | HIS459 |
| A | ALA462 |
| A | TYR464 |
| A | HOH782 |
| site_id | AD6 |
| Number of Residues | 3 |
| Details | binding site for residue GOL A 615 |
| Chain | Residue |
| A | HIS56 |
| A | HOH726 |
| A | HOH956 |
| site_id | AD7 |
| Number of Residues | 3 |
| Details | binding site for residue CL A 616 |
| Chain | Residue |
| A | TYR22 |
| A | ARG97 |
| A | HOH751 |
| site_id | AD8 |
| Number of Residues | 10 |
| Details | binding site for residue GOL A 617 |
| Chain | Residue |
| A | LEU92 |
| A | ARG95 |
| A | ILE107 |
| A | VAL108 |
| A | ASP109 |
| A | VAL110 |
| A | ASN281 |
| A | HOH839 |
| A | HOH1015 |
| A | HOH1071 |
| site_id | AD9 |
| Number of Residues | 2 |
| Details | binding site for residue CL A 618 |
| Chain | Residue |
| A | ASN149 |
| A | LYS157 |
| site_id | AE1 |
| Number of Residues | 4 |
| Details | binding site for residue ACT A 619 |
| Chain | Residue |
| A | ARG365 |
| B | LYS148 |
| B | HOH805 |
| A | ASP331 |
| site_id | AE2 |
| Number of Residues | 5 |
| Details | binding site for residue ACT A 620 |
| Chain | Residue |
| A | GLN361 |
| A | SER372 |
| A | LEU373 |
| A | HOH740 |
| A | HOH912 |
| site_id | AE3 |
| Number of Residues | 2 |
| Details | binding site for residue FE B 601 |
| Chain | Residue |
| B | 9YH602 |
| B | HOH989 |
| site_id | AE4 |
| Number of Residues | 13 |
| Details | binding site for residue 9YH B 602 |
| Chain | Residue |
| B | TYR22 |
| B | MET27 |
| B | ARG97 |
| B | TRP100 |
| B | ARG137 |
| B | TYR382 |
| B | TRP398 |
| B | THR490 |
| B | FE601 |
| B | HOH732 |
| B | HOH867 |
| B | HOH988 |
| B | HOH989 |
| site_id | AE5 |
| Number of Residues | 4 |
| Details | binding site for residue ACT B 603 |
| Chain | Residue |
| A | ASN75 |
| B | THR203 |
| B | PRO225 |
| B | ASP227 |
| site_id | AE6 |
| Number of Residues | 5 |
| Details | binding site for residue GOL B 604 |
| Chain | Residue |
| B | ALA486 |
| B | ALA489 |
| B | HOH705 |
| B | HOH876 |
| B | HOH882 |
| site_id | AE7 |
| Number of Residues | 8 |
| Details | binding site for residue GOL B 605 |
| Chain | Residue |
| B | TRP10 |
| B | PRO11 |
| B | GLY219 |
| B | ASN220 |
| B | GLY222 |
| B | LEU223 |
| B | GOL606 |
| B | HOH859 |
| site_id | AE8 |
| Number of Residues | 9 |
| Details | binding site for residue GOL B 606 |
| Chain | Residue |
| B | ASN220 |
| B | GLU247 |
| B | ARG396 |
| B | ALA489 |
| B | THR490 |
| B | GOL605 |
| B | HOH734 |
| B | HOH901 |
| B | HOH993 |
| site_id | AE9 |
| Number of Residues | 5 |
| Details | binding site for residue CL B 607 |
| Chain | Residue |
| B | MET27 |
| B | PHE28 |
| B | THR490 |
| B | HOH922 |
| B | HOH964 |
| site_id | AF1 |
| Number of Residues | 3 |
| Details | binding site for residue ACT B 608 |
| Chain | Residue |
| B | ASN183 |
| B | HOH752 |
| B | HOH1007 |
| site_id | AF2 |
| Number of Residues | 8 |
| Details | binding site for residue GOL B 609 |
| Chain | Residue |
| B | ASN261 |
| B | LEU263 |
| B | ARG266 |
| B | LEU425 |
| B | ALA426 |
| B | GLU461 |
| B | HOH711 |
| B | HOH811 |
| site_id | AF3 |
| Number of Residues | 4 |
| Details | binding site for residue ACT B 610 |
| Chain | Residue |
| B | HIS56 |
| B | TRP63 |
| B | HOH707 |
| B | HOH896 |
| site_id | AF4 |
| Number of Residues | 2 |
| Details | binding site for residue ACT B 611 |
| Chain | Residue |
| A | LYS335 |
| B | ARG341 |
Functional Information from PROSITE/UniProt
| site_id | PS01040 |
| Number of Residues | 23 |
| Details | SBP_BACTERIAL_5 Bacterial extracellular solute-binding proteins, family 5 signature. AkswthseDgkTWtFtLRDDVKF |
| Chain | Residue | Details |
| A | ALA51-PHE73 |
