5OMY

HIGH-SALT STRUCTURE OF PROTEIN KINASE CK2 CATALYTIC SUBUNIT (ISOFORM CK2ALPHA) IN COMPLEX WITH THE INDENOINDOLE-TYPE INHIBITOR 4P

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0000785	cellular_component	chromatin
A	0004672	molecular_function	protein kinase activity
A	0004674	molecular_function	protein serine/threonine kinase activity
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005829	cellular_component	cytosol
A	0005886	cellular_component	plasma membrane
A	0005956	cellular_component	protein kinase CK2 complex
A	0006302	biological_process	double-strand break repair
A	0006457	biological_process	protein folding
A	0006468	biological_process	protein phosphorylation
A	0006915	biological_process	apoptotic process
A	0006974	biological_process	DNA damage response
A	0007165	biological_process	signal transduction
A	0008284	biological_process	positive regulation of cell population proliferation
A	0016055	biological_process	Wnt signaling pathway
A	0016301	molecular_function	kinase activity
A	0016605	cellular_component	PML body
A	0016740	molecular_function	transferase activity
A	0017148	biological_process	negative regulation of translation
A	0018105	biological_process	peptidyl-serine phosphorylation
A	0030177	biological_process	positive regulation of Wnt signaling pathway
A	0030307	biological_process	positive regulation of cell growth
A	0031507	biological_process	heterochromatin formation
A	0031519	cellular_component	PcG protein complex
A	0032435	biological_process	negative regulation of proteasomal ubiquitin-dependent protein catabolic process
A	0035102	cellular_component	PRC1 complex
A	0042176	biological_process	regulation of protein catabolic process
A	0042802	molecular_function	identical protein binding
A	0045732	biological_process	positive regulation of protein catabolic process
A	0045893	biological_process	positive regulation of DNA-templated transcription
A	0048511	biological_process	rhythmic process
A	0050821	biological_process	protein stabilization
A	0051726	biological_process	regulation of cell cycle
A	0051879	molecular_function	Hsp90 protein binding
A	0070822	cellular_component	Sin3-type complex
A	0075342	biological_process	symbiont-mediated disruption of host cell PML body
A	0106310	molecular_function	protein serine kinase activity
A	1901797	biological_process	negative regulation of signal transduction by p53 class mediator
A	1905337	biological_process	positive regulation of aggrephagy
A	1905818	biological_process	regulation of chromosome separation
A	2000042	biological_process	negative regulation of double-strand break repair via homologous recombination
A	2001234	biological_process	negative regulation of apoptotic signaling pathway

Functional Information from PDB Data

site_id	AC1
Number of Residues	14
Details	binding site for residue 9YE A 401

Chain	Residue
A	LEU45
A	HIS160
A	MET163
A	ILE174
A	ASP175
A	HOH505
A	GLY46
A	GLY48
A	SER51
A	VAL66
A	LYS68
A	ILE95
A	ASN118
A	ASP120

---

site_id	AC2
Number of Residues	2
Details	binding site for residue CL A 402

Chain	Residue
A	HIS148
A	ALA315

---

site_id	AC3
Number of Residues	2
Details	binding site for residue CL A 403

Chain	Residue
A	ARG155
A	ASN189

---

site_id	AC4
Number of Residues	4
Details	binding site for residue CL A 404

Chain	Residue
A	LYS229
A	PHE232
A	HIS234
A	ARG244

---

site_id	AC5
Number of Residues	3
Details	binding site for residue CL A 405

Chain	Residue
A	LYS122
A	PRO159
A	HIS160

---

site_id	AC6
Number of Residues	2
Details	binding site for residue CL A 406

Chain	Residue
A	ARG43
A	GLU187

---

Functional Information from PROSITE/UniProt

site_id	PS00107
Number of Residues	24
Details	PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGRGKYSEVFeAinitnnek..........VVVK

Chain	Residue	Details
A	LEU45-LYS68

---

site_id	PS00108
Number of Residues	13
Details	PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. ImHrDVKphNVMI

Chain	Residue	Details
A	ILE152-ILE164

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	285
Details	Domain: {"description":"Protein kinase","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	5
Details	Region: {"description":"Interaction with beta subunit","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	Active site: {"description":"Proton acceptor"}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	9
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---