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Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

5OLH

Structure of the A2A-StaR2-bRIL562-Vipadenant complex at 2.6A obtained from in meso soaking experiments.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001609	molecular_function	G protein-coupled adenosine receptor activity
A	0001973	biological_process	G protein-coupled adenosine receptor signaling pathway
A	0004930	molecular_function	G protein-coupled receptor activity
A	0005506	molecular_function	iron ion binding
A	0007186	biological_process	G protein-coupled receptor signaling pathway
A	0009055	molecular_function	electron transfer activity
A	0016020	cellular_component	membrane
A	0020037	molecular_function	heme binding
A	0022900	biological_process	electron transport chain
A	0042597	cellular_component	periplasmic space
A	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	15
Details	binding site for residue 9XT A 1201

Chain	Residue
A	TYR9
A	HIS250
A	ASN253
A	TYR271
A	ILE274
A	HOH1321
A	HOH1322
A	ALA63
A	ILE66
A	LEU85
A	PHE168
A	GLU169
A	MET177
A	TRP246
A	LEU249

site_id	AC2
Number of Residues	3
Details	binding site for residue OLA A 1202

Chain	Residue
A	PHE133
A	OLC1224
A	OLC1226

site_id	AC3
Number of Residues	3
Details	binding site for residue NA A 1203

Chain	Residue
A	ASP52
A	SER91
A	HOH1309

site_id	AC4
Number of Residues	7
Details	binding site for residue CLR A 1204

Chain	Residue
A	ALA72
A	ALA73
A	GLY76
A	CLR1206
A	OLC1220
A	OLC1223
A	OLC1224

site_id	AC5
Number of Residues	4
Details	binding site for residue CLR A 1205

Chain	Residue
A	PRO248
A	CYS262
A	SER263
A	OLC1222

site_id	AC6
Number of Residues	5
Details	binding site for residue CLR A 1206

Chain	Residue
A	PHE255
A	CLR1204
A	OLA1219
A	OLC1220
A	OLC1223

site_id	AC7
Number of Residues	5
Details	binding site for residue OLA A 1207

Chain	Residue
A	PHE44
A	ALA97
A	ILE100
A	VAL116
A	ILE124

site_id	AC8
Number of Residues	3
Details	binding site for residue OLA A 1208

Chain	Residue
A	LEU267
A	VAL275
A	OLA1217

site_id	AC9
Number of Residues	5
Details	binding site for residue OLA A 1209

Chain	Residue
A	LEU96
A	PRO189
A	LEU192
A	OLA1215
A	OLC1226

site_id	AD1
Number of Residues	5
Details	binding site for residue OLA A 1211

Chain	Residue
A	VAL8
A	LEU19
A	LEU22
A	LEU26
A	PHE286

site_id	AD2
Number of Residues	1
Details	binding site for residue OLA A 1213

Chain	Residue
A	OLC1222

site_id	AD3
Number of Residues	6
Details	binding site for residue OLA A 1214

Chain	Residue
A	VAL25
A	TRP29
A	TRP32
A	PHE201
A	VAL229
A	LYS233

site_id	AD4
Number of Residues	2
Details	binding site for residue OLA A 1215

Chain	Residue
A	ILE127
A	OLA1209

site_id	AD5
Number of Residues	1
Details	binding site for residue OLA A 1216

Chain	Residue
A	ILE287

site_id	AD6
Number of Residues	2
Details	binding site for residue OLA A 1217

Chain	Residue
A	PHE286
A	OLA1208

site_id	AD7
Number of Residues	2
Details	binding site for residue OLA A 1218

Chain	Residue
A	ALA236
A	OLA1219

site_id	AD8
Number of Residues	5
Details	binding site for residue OLA A 1219

Chain	Residue
A	TYR197
A	ALA236
A	ALA239
A	CLR1206
A	OLA1218

site_id	AD9
Number of Residues	5
Details	binding site for residue OLC A 1220

Chain	Residue
A	PHE183
A	PHE258
A	CLR1204
A	CLR1206
A	OLC1221

site_id	AE1
Number of Residues	3
Details	binding site for residue OLC A 1221

Chain	Residue
A	TYR179
A	OLC1220
A	OLC1226

site_id	AE2
Number of Residues	4
Details	binding site for residue OLC A 1222

Chain	Residue
A	PHE255
A	CLR1205
A	OLA1213
A	OLC1227

site_id	AE3
Number of Residues	6
Details	binding site for residue OLC A 1223

Chain	Residue
A	VAL57
A	PRO61
A	PHE70
A	CLR1204
A	CLR1206
A	OLC1227

site_id	AE4
Number of Residues	9
Details	binding site for residue OLC A 1224

Chain	Residue
A	CLR1204
A	OLC1225
A	TYR43
A	LEU54
A	LEU58
A	PHE83
A	ILE125
A	TRP129
A	OLA1202

site_id	AE5
Number of Residues	6
Details	binding site for residue OLC A 1225

Chain	Residue
A	CYS28
A	GLN38
A	TYR43
A	ALA50
A	ARG205
A	OLC1224

site_id	AE6
Number of Residues	9
Details	binding site for residue OLC A 1226

Chain	Residue
A	HIS75
A	MET140
A	LEU141
A	GLY142
A	TYR179
A	ALA184
A	OLA1202
A	OLA1209
A	OLC1221

site_id	AE7
Number of Residues	3
Details	binding site for residue OLC A 1227

Chain	Residue
A	THR65
A	OLC1222
A	OLC1223

site_id	AE8
Number of Residues	1
Details	binding site for residue OLA A 1228

Chain	Residue
A	THR11

Functional Information from PROSITE/UniProt

site_id	PS00237
Number of Residues	17
Details	G_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. SSIfSLLAIAIDRYIaI

Chain	Residue	Details
A	SER90-ILE106

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	24
Details	TRANSMEM: Helical; Name=1

Chain	Residue	Details
A	VAL8-TRP32

site_id	SWS_FT_FI2
Number of Residues	28
Details	TOPO_DOM: Cytoplasmic => ECO:0000269\|PubMed:18832607

Chain	Residue	Details
A	LEU33-ASN42
A	ASP101-ARG120

site_id	SWS_FT_FI3
Number of Residues	23
Details	TRANSMEM: Helical; Name=2

Chain	Residue	Details
A	TYR43-ILE66

site_id	SWS_FT_FI4
Number of Residues	46
Details	TOPO_DOM: Extracellular => ECO:0000269\|PubMed:18832607

Chain	Residue	Details
A	SER67-CYS77
A	ASN144-PRO173
A	CYS259-PRO266

site_id	SWS_FT_FI5
Number of Residues	22
Details	TRANSMEM: Helical; Name=3

Chain	Residue	Details
A	LEU78-ILE100

site_id	SWS_FT_FI6
Number of Residues	22
Details	TRANSMEM: Helical; Name=4

Chain	Residue	Details
A	ALA121-TRP143

site_id	SWS_FT_FI7
Number of Residues	24
Details	TRANSMEM: Helical; Name=5

Chain	Residue	Details
A	MET174-LEU198

site_id	SWS_FT_FI8
Number of Residues	23
Details	TRANSMEM: Helical; Name=6

Chain	Residue	Details
A	ALA235-PHE258

site_id	SWS_FT_FI9
Number of Residues	23
Details	TRANSMEM: Helical; Name=7

Chain	Residue	Details
A	LEU267-TYR290

site_id	SWS_FT_FI10
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269\|PubMed:21593763, ECO:0007744\|PDB:2YDO

Chain	Residue	Details
A	GLU169
A	ASN253
A	ALA277
A	HIS278

site_id	SWS_FT_FI11
Number of Residues	1
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
A	ALA154

site_id	SWS_FT_FI12
Number of Residues	2
Details	BINDING: axial binding residue

Chain	Residue	Details
A	TRP1007
A	ILE1102

226707

PDB entries from 2024-10-30

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