5OLE

X-ray structure of the adduct formed upon reaction of hen egg white lysozyme with a tetranuclear Pt-thiosemicarbazone compound

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003796	molecular_function	lysozyme activity
A	0003824	molecular_function	catalytic activity
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005615	cellular_component	extracellular space
A	0005737	cellular_component	cytoplasm
A	0005783	cellular_component	endoplasmic reticulum
A	0016231	molecular_function	beta-N-acetylglucosaminidase activity
A	0016787	molecular_function	hydrolase activity
A	0016798	molecular_function	hydrolase activity, acting on glycosyl bonds
A	0016998	biological_process	cell wall macromolecule catabolic process
A	0031640	biological_process	killing of cells of another organism
A	0042742	biological_process	defense response to bacterium
A	0042802	molecular_function	identical protein binding
A	0050829	biological_process	defense response to Gram-negative bacterium
A	0050830	biological_process	defense response to Gram-positive bacterium
A	0051672	biological_process	obsolete catabolism by organism of cell wall peptidoglycan in other organism

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	binding site for residue EDO A 201

Chain	Residue
A	GLN57
A	ILE58
A	ASN59
A	TRP63
A	TRP108
A	NO3204

---

site_id	AC2
Number of Residues	5
Details	binding site for residue NO3 A 202

Chain	Residue
A	GLN121
A	ILE124
A	SER24
A	LEU25
A	GLY26

---

site_id	AC3
Number of Residues	6
Details	binding site for residue NO3 A 203

Chain	Residue
A	ASN65
A	ASN74
A	ASN77
A	ILE78
A	PRO79
A	HOH342

---

site_id	AC4
Number of Residues	3
Details	binding site for residue NO3 A 204

Chain	Residue
A	TRP63
A	EDO201
A	HOH303

---

site_id	AC5
Number of Residues	4
Details	binding site for residue NO3 A 205

Chain	Residue
A	ARG5
A	LYS33
A	PHE38
A	TRP123

---

site_id	AC6
Number of Residues	10
Details	binding site for residue NO3 A 206

Chain	Residue
A	CYS64
A	ASN65
A	ASP66
A	GLY67
A	ARG68
A	THR69
A	SER72
A	HOH301
A	HOH305
A	HOH361

---

site_id	AC7
Number of Residues	9
Details	binding site for residue NO3 A 207

Chain	Residue
A	ARG21
A	VAL99
A	SER100
A	GLY102
A	ASN103
A	GLY104
A	VAL109
A	ASN113
A	HOH328

---

site_id	AC8
Number of Residues	2
Details	binding site for residue DMS A 208

Chain	Residue
A	ILE88
A	PT212

---

site_id	AC9
Number of Residues	4
Details	binding site for residue DMS A 209

Chain	Residue
A	ARG14
A	HIS15
A	ARG128
A	PT211

---

site_id	AD1
Number of Residues	2
Details	binding site for residue DMS A 210

Chain	Residue
A	HIS15
A	PT211

---

site_id	AD2
Number of Residues	4
Details	binding site for residue PT A 211

Chain	Residue
A	HIS15
A	DMS209
A	DMS210
A	HOH397

---

site_id	AD3
Number of Residues	4
Details	binding site for residue PT A 212

Chain	Residue
A	ARG14
A	HIS15
A	DMS208
A	HOH377

---

site_id	AD4
Number of Residues	5
Details	binding site for residue EDO A 213

Chain	Residue
A	CYS6
A	GLY126
A	CYS127
A	ARG128
A	HOH353

---

Functional Information from PROSITE/UniProt

site_id	PS00128
Number of Residues	19
Details	GLYCOSYL_HYDROL_F22_1 Glycosyl hydrolases family 22 (GH22) domain signature. CnipCsaLlssDItasvnC

Chain	Residue	Details
A	CYS76-CYS94

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	128
Details	Domain: {"description":"C-type lysozyme","evidences":[{"source":"PROSITE-ProRule","id":"PRU00680","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	Active site: {}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	Binding site: {}

Chain

Residue

Details

---

Catalytic Information from CSA

site_id	MCSA1
Number of Residues	6
Details	M-CSA 203

Chain	Residue	Details
A	GLU35	hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor
A	ASN46
A	ASP48
A	SER50
A	ASP52	covalently attached, electrostatic stabiliser, nucleofuge, nucleophile, polar/non-polar interaction
A	ASN59

---