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5OKF

CH1 chimera of human 14-3-3 sigma with the HSPB6 phosphopeptide in a conformation with self-bound phosphopeptides

Functional Information from GO Data
ChainGOidnamespacecontents
A0000122biological_processnegative regulation of transcription by RNA polymerase II
A0001836biological_processrelease of cytochrome c from mitochondria
A0003334biological_processkeratinocyte development
A0005515molecular_functionprotein binding
A0005576cellular_componentextracellular region
A0005615cellular_componentextracellular space
A0005634cellular_componentnucleus
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0006469biological_processnegative regulation of protein kinase activity
A0006611biological_processprotein export from nucleus
A0007165biological_processsignal transduction
A0008104biological_processprotein localization
A0008426molecular_functionprotein kinase C inhibitor activity
A0008630biological_processintrinsic apoptotic signaling pathway in response to DNA damage
A0010482biological_processregulation of epidermal cell division
A0010839biological_processnegative regulation of keratinocyte proliferation
A0019901molecular_functionprotein kinase binding
A0022407biological_processregulation of cell-cell adhesion
A0030216biological_processkeratinocyte differentiation
A0030307biological_processpositive regulation of cell growth
A0031424biological_processkeratinization
A0032880biological_processregulation of protein localization
A0042802molecular_functionidentical protein binding
A0043588biological_processskin development
A0043616biological_processkeratinocyte proliferation
A0045296molecular_functioncadherin binding
A0045606biological_processpositive regulation of epidermal cell differentiation
A0045785biological_processpositive regulation of cell adhesion
A0045824biological_processnegative regulation of innate immune response
A0046827biological_processpositive regulation of protein export from nucleus
A0050815molecular_functionphosphoserine residue binding
A0051219molecular_functionphosphoprotein binding
A0051726biological_processregulation of cell cycle
A0061436biological_processestablishment of skin barrier
A0070062cellular_componentextracellular exosome
A0072089biological_processstem cell proliferation
A0140311molecular_functionprotein sequestering activity
A0141156biological_processcAMP/PKA signal transduction
A1903077biological_processnegative regulation of protein localization to plasma membrane
A1903829biological_processpositive regulation of protein localization
A2000647biological_processnegative regulation of stem cell proliferation
B0000122biological_processnegative regulation of transcription by RNA polymerase II
B0001836biological_processrelease of cytochrome c from mitochondria
B0003334biological_processkeratinocyte development
B0005515molecular_functionprotein binding
B0005576cellular_componentextracellular region
B0005615cellular_componentextracellular space
B0005634cellular_componentnucleus
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0006469biological_processnegative regulation of protein kinase activity
B0006611biological_processprotein export from nucleus
B0007165biological_processsignal transduction
B0008104biological_processprotein localization
B0008426molecular_functionprotein kinase C inhibitor activity
B0008630biological_processintrinsic apoptotic signaling pathway in response to DNA damage
B0010482biological_processregulation of epidermal cell division
B0010839biological_processnegative regulation of keratinocyte proliferation
B0019901molecular_functionprotein kinase binding
B0022407biological_processregulation of cell-cell adhesion
B0030216biological_processkeratinocyte differentiation
B0030307biological_processpositive regulation of cell growth
B0031424biological_processkeratinization
B0032880biological_processregulation of protein localization
B0042802molecular_functionidentical protein binding
B0043588biological_processskin development
B0043616biological_processkeratinocyte proliferation
B0045296molecular_functioncadherin binding
B0045606biological_processpositive regulation of epidermal cell differentiation
B0045785biological_processpositive regulation of cell adhesion
B0045824biological_processnegative regulation of innate immune response
B0046827biological_processpositive regulation of protein export from nucleus
B0050815molecular_functionphosphoserine residue binding
B0051219molecular_functionphosphoprotein binding
B0051726biological_processregulation of cell cycle
B0061436biological_processestablishment of skin barrier
B0070062cellular_componentextracellular exosome
B0072089biological_processstem cell proliferation
B0140311molecular_functionprotein sequestering activity
B0141156biological_processcAMP/PKA signal transduction
B1903077biological_processnegative regulation of protein localization to plasma membrane
B1903829biological_processpositive regulation of protein localization
B2000647biological_processnegative regulation of stem cell proliferation
C0000122biological_processnegative regulation of transcription by RNA polymerase II
C0001836biological_processrelease of cytochrome c from mitochondria
C0003334biological_processkeratinocyte development
C0005515molecular_functionprotein binding
C0005576cellular_componentextracellular region
C0005615cellular_componentextracellular space
C0005634cellular_componentnucleus
C0005737cellular_componentcytoplasm
C0005829cellular_componentcytosol
C0006469biological_processnegative regulation of protein kinase activity
C0006611biological_processprotein export from nucleus
C0007165biological_processsignal transduction
C0008104biological_processprotein localization
C0008426molecular_functionprotein kinase C inhibitor activity
C0008630biological_processintrinsic apoptotic signaling pathway in response to DNA damage
C0010482biological_processregulation of epidermal cell division
C0010839biological_processnegative regulation of keratinocyte proliferation
C0019901molecular_functionprotein kinase binding
C0022407biological_processregulation of cell-cell adhesion
C0030216biological_processkeratinocyte differentiation
C0030307biological_processpositive regulation of cell growth
C0031424biological_processkeratinization
C0032880biological_processregulation of protein localization
C0042802molecular_functionidentical protein binding
C0043588biological_processskin development
C0043616biological_processkeratinocyte proliferation
C0045296molecular_functioncadherin binding
C0045606biological_processpositive regulation of epidermal cell differentiation
C0045785biological_processpositive regulation of cell adhesion
C0045824biological_processnegative regulation of innate immune response
C0046827biological_processpositive regulation of protein export from nucleus
C0050815molecular_functionphosphoserine residue binding
C0051219molecular_functionphosphoprotein binding
C0051726biological_processregulation of cell cycle
C0061436biological_processestablishment of skin barrier
C0070062cellular_componentextracellular exosome
C0072089biological_processstem cell proliferation
C0140311molecular_functionprotein sequestering activity
C0141156biological_processcAMP/PKA signal transduction
C1903077biological_processnegative regulation of protein localization to plasma membrane
C1903829biological_processpositive regulation of protein localization
C2000647biological_processnegative regulation of stem cell proliferation
D0000122biological_processnegative regulation of transcription by RNA polymerase II
D0001836biological_processrelease of cytochrome c from mitochondria
D0003334biological_processkeratinocyte development
D0005515molecular_functionprotein binding
D0005576cellular_componentextracellular region
D0005615cellular_componentextracellular space
D0005634cellular_componentnucleus
D0005737cellular_componentcytoplasm
D0005829cellular_componentcytosol
D0006469biological_processnegative regulation of protein kinase activity
D0006611biological_processprotein export from nucleus
D0007165biological_processsignal transduction
D0008104biological_processprotein localization
D0008426molecular_functionprotein kinase C inhibitor activity
D0008630biological_processintrinsic apoptotic signaling pathway in response to DNA damage
D0010482biological_processregulation of epidermal cell division
D0010839biological_processnegative regulation of keratinocyte proliferation
D0019901molecular_functionprotein kinase binding
D0022407biological_processregulation of cell-cell adhesion
D0030216biological_processkeratinocyte differentiation
D0030307biological_processpositive regulation of cell growth
D0031424biological_processkeratinization
D0032880biological_processregulation of protein localization
D0042802molecular_functionidentical protein binding
D0043588biological_processskin development
D0043616biological_processkeratinocyte proliferation
D0045296molecular_functioncadherin binding
D0045606biological_processpositive regulation of epidermal cell differentiation
D0045785biological_processpositive regulation of cell adhesion
D0045824biological_processnegative regulation of innate immune response
D0046827biological_processpositive regulation of protein export from nucleus
D0050815molecular_functionphosphoserine residue binding
D0051219molecular_functionphosphoprotein binding
D0051726biological_processregulation of cell cycle
D0061436biological_processestablishment of skin barrier
D0070062cellular_componentextracellular exosome
D0072089biological_processstem cell proliferation
D0140311molecular_functionprotein sequestering activity
D0141156biological_processcAMP/PKA signal transduction
D1903077biological_processnegative regulation of protein localization to plasma membrane
D1903829biological_processpositive regulation of protein localization
D2000647biological_processnegative regulation of stem cell proliferation
Functional Information from PDB Data
site_idAC1
Number of Residues2
Detailsbinding site for residue CD A 301
ChainResidue
ACSO38
AGLU115

site_idAC2
Number of Residues3
Detailsbinding site for residue CD A 302
ChainResidue
AHIS106
AGLU110
DASP139

site_idAC3
Number of Residues2
Detailsbinding site for residue CD A 303
ChainResidue
AARG85
AGLU89

site_idAC4
Number of Residues2
Detailsbinding site for residue CD A 304
ChainResidue
ACSO38
AGLU115

site_idAC5
Number of Residues3
Detailsbinding site for residue CD A 305
ChainResidue
AASP97
DGLU31
DHIS106

site_idAC6
Number of Residues3
Detailsbinding site for residue CD B 301
ChainResidue
BHIS106
BGLU110
CASP139

site_idAC7
Number of Residues2
Detailsbinding site for residue CD B 302
ChainResidue
BHIS106
CASP97

site_idAC8
Number of Residues3
Detailsbinding site for residue CD B 303
ChainResidue
BASP97
CGLU31
CHIS106

site_idAC9
Number of Residues2
Detailsbinding site for residue CD B 304
ChainResidue
BCSO38
BGLU115

site_idAD1
Number of Residues1
Detailsbinding site for residue CD B 305
ChainResidue
BGLU115

site_idAD2
Number of Residues3
Detailsbinding site for residue CD B 306
ChainResidue
BASP139
CHIS106
CGLU110

site_idAD3
Number of Residues2
Detailsbinding site for residue CD C 301
ChainResidue
CARG85
CGLU89

site_idAD4
Number of Residues3
Detailsbinding site for residue CD C 302
ChainResidue
CCSO38
CGLU115
DASP138

site_idAD5
Number of Residues2
Detailsbinding site for residue CD D 301
ChainResidue
AHIS106
DASP97

site_idAD6
Number of Residues3
Detailsbinding site for residue CD D 302
ChainResidue
AASP139
DHIS106
DGLU110

site_idAD7
Number of Residues2
Detailsbinding site for residue CD D 303
ChainResidue
DCSO38
DGLU115

site_idAD8
Number of Residues1
Detailsbinding site for residue CD D 304
ChainResidue
DGLU115

Functional Information from PROSITE/UniProt
site_idPS00796
Number of Residues11
Details1433_1 14-3-3 proteins signature 1. RNLLSVAYKNV
ChainResidueDetails
AARG41-VAL51

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues8
DetailsSITE: Interaction with phosphoserine on interacting protein
ChainResidueDetails
AARG56
AARG129
BARG56
BARG129
CARG56
CARG129
DARG56
DARG129

site_idSWS_FT_FI2
Number of Residues4
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:20068231
ChainResidueDetails
ASER5
BSER5
CSER5
DSER5

site_idSWS_FT_FI3
Number of Residues4
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163
ChainResidueDetails
ASER74
BSER74
CSER74
DSER74

site_idSWS_FT_FI4
Number of Residues4
DetailsMOD_RES: Phosphoserine; by PKA => ECO:0000269|PubMed:21334344, ECO:0007744|PubMed:24275569
ChainResidueDetails
ASEP240
BSEP240
CSEP240
DSEP240

225158

PDB entries from 2024-09-18

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