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5OJG

Crystal structure of the dehydrogenase/reductase SDR family member 4 (DHRS4) from Caenorhabditis elegans

Functional Information from GO Data
ChainGOidnamespacecontents
A0003824molecular_functioncatalytic activity
A0004090molecular_functioncarbonyl reductase (NADPH) activity
A0016491molecular_functionoxidoreductase activity
B0003824molecular_functioncatalytic activity
B0004090molecular_functioncarbonyl reductase (NADPH) activity
B0016491molecular_functionoxidoreductase activity
Functional Information from PDB Data
site_idAC1
Number of Residues34
Detailsbinding site for residue NAP A 301
ChainResidue
AALA17
AGLY67
AILE69
AASN95
AHIS96
AGLY97
AASN146
AALA147
ASER148
ATYR161
ALYS165
ATHR19
APRO191
AGLY192
AILE194
ATHR196
ALYS197
AMET198
ASER199
ABUO302
AHOH405
AHOH437
ALYS20
AHOH440
AHOH446
AHOH475
AHOH521
AHOH528
AGLY21
AILE22
ASER41
AARG42
AASN43
AASN46

site_idAC2
Number of Residues4
Detailsbinding site for residue BUO A 302
ChainResidue
ASER148
ASER150
ATYR161
ANAP301

site_idAC3
Number of Residues34
Detailsbinding site for residue NAP B 301
ChainResidue
BALA17
BTHR19
BLYS20
BGLY21
BILE22
BSER41
BARG42
BASN43
BASN46
BGLY67
BILE69
BASN95
BHIS96
BGLY97
BASN146
BALA147
BSER148
BTYR161
BLYS165
BPRO191
BGLY192
BILE194
BTHR196
BLYS197
BMET198
BSER199
BBUO302
BHOH409
BHOH410
BHOH435
BHOH445
BHOH473
BHOH535
BHOH570

site_idAC4
Number of Residues6
Detailsbinding site for residue BUO B 302
ChainResidue
BSER148
BTYR149
BSER150
BTYR161
BNAP301
BHOH438

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsACT_SITE: Proton acceptor => ECO:0000250|UniProtKB:Q8WNV7
ChainResidueDetails
ATYR161
BTYR161

site_idSWS_FT_FI2
Number of Residues4
DetailsBINDING: BINDING => ECO:0000250|UniProtKB:Q8WNV7
ChainResidueDetails
AILE14
ALYS165
BILE14
BLYS165

site_idSWS_FT_FI3
Number of Residues2
DetailsBINDING: BINDING => ECO:0000250|UniProtKB:Q7Z4W1
ChainResidueDetails
ASER148
BSER148

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PDB entries from 2024-11-06

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