5OHZ
Crystal structure of Mycolicibacterium hassiacum glucosylglycerate hydrolase (MhGgH) - SeMet derivative
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004573 | molecular_function | Glc3Man9GlcNAc2 oligosaccharide glucosidase activity |
| A | 0005975 | biological_process | carbohydrate metabolic process |
| A | 0006487 | biological_process | protein N-linked glycosylation |
| A | 0009311 | biological_process | oligosaccharide metabolic process |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0016798 | molecular_function | hydrolase activity, acting on glycosyl bonds |
| A | 0102547 | molecular_function | glucosylglycerate hydrolase activity |
| B | 0004573 | molecular_function | Glc3Man9GlcNAc2 oligosaccharide glucosidase activity |
| B | 0005975 | biological_process | carbohydrate metabolic process |
| B | 0006487 | biological_process | protein N-linked glycosylation |
| B | 0009311 | biological_process | oligosaccharide metabolic process |
| B | 0016787 | molecular_function | hydrolase activity |
| B | 0016798 | molecular_function | hydrolase activity, acting on glycosyl bonds |
| B | 0102547 | molecular_function | glucosylglycerate hydrolase activity |
| C | 0004573 | molecular_function | Glc3Man9GlcNAc2 oligosaccharide glucosidase activity |
| C | 0005975 | biological_process | carbohydrate metabolic process |
| C | 0006487 | biological_process | protein N-linked glycosylation |
| C | 0009311 | biological_process | oligosaccharide metabolic process |
| C | 0016787 | molecular_function | hydrolase activity |
| C | 0016798 | molecular_function | hydrolase activity, acting on glycosyl bonds |
| C | 0102547 | molecular_function | glucosylglycerate hydrolase activity |
| D | 0004573 | molecular_function | Glc3Man9GlcNAc2 oligosaccharide glucosidase activity |
| D | 0005975 | biological_process | carbohydrate metabolic process |
| D | 0006487 | biological_process | protein N-linked glycosylation |
| D | 0009311 | biological_process | oligosaccharide metabolic process |
| D | 0016787 | molecular_function | hydrolase activity |
| D | 0016798 | molecular_function | hydrolase activity, acting on glycosyl bonds |
| D | 0102547 | molecular_function | glucosylglycerate hydrolase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 9 |
| Details | binding site for residue GOL A 501 |
| Chain | Residue |
| A | TYR36 |
| A | TRP40 |
| A | TRP42 |
| A | ASP43 |
| A | GLN115 |
| A | GLN434 |
| A | TRP436 |
| A | SER505 |
| A | HOH615 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | binding site for residue GOL A 502 |
| Chain | Residue |
| A | GLU296 |
| A | THR297 |
| A | THR298 |
| A | ARG306 |
| A | TRP315 |
| A | HOH702 |
| A | HOH784 |
| site_id | AC3 |
| Number of Residues | 1 |
| Details | binding site for residue GOL A 503 |
| Chain | Residue |
| A | HIS334 |
| site_id | AC4 |
| Number of Residues | 8 |
| Details | binding site for residue GOL A 504 |
| Chain | Residue |
| A | TRP386 |
| A | SER389 |
| A | TRP390 |
| A | ASP443 |
| A | TRP444 |
| A | HOH668 |
| A | HOH697 |
| A | HOH800 |
| site_id | AC5 |
| Number of Residues | 11 |
| Details | binding site for residue SER A 505 |
| Chain | Residue |
| A | TRP40 |
| A | HIS78 |
| A | TYR88 |
| A | ASP182 |
| A | ARG216 |
| A | TYR222 |
| A | TYR375 |
| A | GOL501 |
| A | HOH607 |
| A | HOH625 |
| A | HOH643 |
| site_id | AC6 |
| Number of Residues | 10 |
| Details | binding site for residue GOL B 501 |
| Chain | Residue |
| B | TYR36 |
| B | TRP40 |
| B | TRP42 |
| B | ASP43 |
| B | GLN115 |
| B | TYR375 |
| B | GLN434 |
| B | TRP436 |
| B | SER507 |
| B | HOH673 |
| site_id | AC7 |
| Number of Residues | 8 |
| Details | binding site for residue GOL B 502 |
| Chain | Residue |
| A | GLN11 |
| B | ARG125 |
| B | HIS129 |
| B | GLY446 |
| B | HOH609 |
| B | HOH634 |
| D | GLU399 |
| D | ARG402 |
| site_id | AC8 |
| Number of Residues | 2 |
| Details | binding site for residue GOL B 503 |
| Chain | Residue |
| B | HIS334 |
| D | TYR284 |
| site_id | AC9 |
| Number of Residues | 6 |
| Details | binding site for residue GOL B 504 |
| Chain | Residue |
| B | TRP149 |
| B | GLY150 |
| B | MSE153 |
| B | PRO276 |
| B | ASP279 |
| B | HOH759 |
| site_id | AD1 |
| Number of Residues | 8 |
| Details | binding site for residue GOL B 505 |
| Chain | Residue |
| B | GLU296 |
| B | THR297 |
| B | THR298 |
| B | ARG306 |
| B | TRP315 |
| B | HOH623 |
| B | HOH685 |
| B | HOH788 |
| site_id | AD2 |
| Number of Residues | 8 |
| Details | binding site for residue GOL B 506 |
| Chain | Residue |
| B | TRP386 |
| B | SER389 |
| B | TRP390 |
| B | ASP443 |
| B | TRP444 |
| B | HOH664 |
| B | HOH754 |
| B | HOH762 |
| site_id | AD3 |
| Number of Residues | 11 |
| Details | binding site for residue SER B 507 |
| Chain | Residue |
| B | TRP40 |
| B | HIS78 |
| B | TYR88 |
| B | ASP182 |
| B | ARG216 |
| B | TYR222 |
| B | TYR375 |
| B | GOL501 |
| B | HOH618 |
| B | HOH652 |
| B | HOH689 |
| site_id | AD4 |
| Number of Residues | 7 |
| Details | binding site for residue GOL C 501 |
| Chain | Residue |
| A | ARG125 |
| A | HIS129 |
| A | GLY446 |
| B | GLN11 |
| C | GLU399 |
| C | ARG402 |
| C | HOH647 |
| site_id | AD5 |
| Number of Residues | 8 |
| Details | binding site for residue GOL C 502 |
| Chain | Residue |
| C | ASP43 |
| C | GLN115 |
| C | GLN434 |
| C | SER505 |
| C | HOH627 |
| C | TYR36 |
| C | TRP40 |
| C | TRP42 |
| site_id | AD6 |
| Number of Residues | 7 |
| Details | binding site for residue GOL C 503 |
| Chain | Residue |
| A | GLU399 |
| A | ARG402 |
| C | ARG125 |
| C | HIS129 |
| C | GLY446 |
| C | HOH619 |
| D | GLN11 |
| site_id | AD7 |
| Number of Residues | 6 |
| Details | binding site for residue GOL C 504 |
| Chain | Residue |
| C | THR297 |
| C | THR298 |
| C | ASP299 |
| C | ARG306 |
| C | TRP315 |
| C | HOH741 |
| site_id | AD8 |
| Number of Residues | 9 |
| Details | binding site for residue SER C 505 |
| Chain | Residue |
| C | TYR36 |
| C | TRP40 |
| C | HIS78 |
| C | TYR88 |
| C | ASP182 |
| C | ARG216 |
| C | TYR375 |
| C | GOL502 |
| C | HOH644 |
| site_id | AD9 |
| Number of Residues | 9 |
| Details | binding site for residue GOL D 501 |
| Chain | Residue |
| D | TYR36 |
| D | TRP40 |
| D | TRP42 |
| D | ASP43 |
| D | GLN115 |
| D | GLN434 |
| D | TRP436 |
| D | SER503 |
| D | HOH636 |
| site_id | AE1 |
| Number of Residues | 9 |
| Details | binding site for residue GOL D 502 |
| Chain | Residue |
| B | GLU399 |
| B | ARG402 |
| B | HOH909 |
| C | GLN11 |
| D | ARG125 |
| D | HIS129 |
| D | ASP443 |
| D | GLY446 |
| D | HOH664 |
| site_id | AE2 |
| Number of Residues | 10 |
| Details | binding site for residue SER D 503 |
| Chain | Residue |
| D | TRP40 |
| D | HIS78 |
| D | TYR88 |
| D | ASP182 |
| D | ARG216 |
| D | TYR222 |
| D | TYR375 |
| D | GOL501 |
| D | HOH612 |
| D | HOH706 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | ACT_SITE: Proton donor => ECO:0000305|PubMed:31316802 |
| Chain | Residue | Details |
| A | ASP182 | |
| B | ASP182 | |
| C | ASP182 | |
| D | ASP182 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | ACT_SITE: Proton acceptor => ECO:0000305|PubMed:31316802 |
| Chain | Residue | Details |
| A | GLU419 | |
| B | GLU419 | |
| C | GLU419 | |
| D | GLU419 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 32 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:31316802 |
| Chain | Residue | Details |
| A | TYR36 | |
| B | TRP40 | |
| B | TYR88 | |
| B | GLN115 | |
| B | GLY180 | |
| B | ARG216 | |
| B | TYR375 | |
| B | GLN434 | |
| C | TYR36 | |
| C | TRP40 | |
| C | TYR88 | |
| A | TRP40 | |
| C | GLN115 | |
| C | GLY180 | |
| C | ARG216 | |
| C | TYR375 | |
| C | GLN434 | |
| D | TYR36 | |
| D | TRP40 | |
| D | TYR88 | |
| D | GLN115 | |
| D | GLY180 | |
| A | TYR88 | |
| D | ARG216 | |
| D | TYR375 | |
| D | GLN434 | |
| A | GLN115 | |
| A | GLY180 | |
| A | ARG216 | |
| A | TYR375 | |
| A | GLN434 | |
| B | TYR36 |
